![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TRMT1L |
Gene summary for TRMT1L |
![]() |
Gene information | Species | Human | Gene symbol | TRMT1L | Gene ID | 81627 |
Gene name | tRNA methyltransferase 1 like | |
Gene Alias | C1orf25 | |
Cytomap | 1q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B4DXX1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81627 | TRMT1L | LZE4T | Human | Esophagus | ESCC | 7.61e-08 | 2.37e-01 | 0.0811 |
81627 | TRMT1L | LZE5T | Human | Esophagus | ESCC | 1.08e-02 | 2.08e-01 | 0.0514 |
81627 | TRMT1L | LZE7T | Human | Esophagus | ESCC | 9.87e-03 | 1.81e-01 | 0.0667 |
81627 | TRMT1L | LZE24T | Human | Esophagus | ESCC | 8.11e-06 | 1.77e-01 | 0.0596 |
81627 | TRMT1L | P2T-E | Human | Esophagus | ESCC | 3.52e-19 | 2.88e-01 | 0.1177 |
81627 | TRMT1L | P4T-E | Human | Esophagus | ESCC | 3.43e-12 | 3.19e-01 | 0.1323 |
81627 | TRMT1L | P5T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.38e-01 | 0.1327 |
81627 | TRMT1L | P8T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.25e-01 | 0.0889 |
81627 | TRMT1L | P9T-E | Human | Esophagus | ESCC | 5.07e-04 | 1.61e-01 | 0.1131 |
81627 | TRMT1L | P10T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.00e-01 | 0.116 |
81627 | TRMT1L | P11T-E | Human | Esophagus | ESCC | 1.78e-05 | 2.51e-01 | 0.1426 |
81627 | TRMT1L | P12T-E | Human | Esophagus | ESCC | 9.11e-10 | 2.53e-01 | 0.1122 |
81627 | TRMT1L | P15T-E | Human | Esophagus | ESCC | 3.30e-12 | 2.85e-01 | 0.1149 |
81627 | TRMT1L | P16T-E | Human | Esophagus | ESCC | 4.62e-21 | 2.10e-01 | 0.1153 |
81627 | TRMT1L | P17T-E | Human | Esophagus | ESCC | 4.97e-03 | 1.43e-01 | 0.1278 |
81627 | TRMT1L | P19T-E | Human | Esophagus | ESCC | 2.38e-03 | 2.35e-01 | 0.1662 |
81627 | TRMT1L | P20T-E | Human | Esophagus | ESCC | 8.93e-13 | 3.21e-01 | 0.1124 |
81627 | TRMT1L | P21T-E | Human | Esophagus | ESCC | 1.10e-11 | 1.92e-01 | 0.1617 |
81627 | TRMT1L | P22T-E | Human | Esophagus | ESCC | 2.20e-17 | 2.95e-01 | 0.1236 |
81627 | TRMT1L | P23T-E | Human | Esophagus | ESCC | 2.60e-09 | 2.35e-01 | 0.108 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:0030488 | Liver | HCC | tRNA methylation | 29/7958 | 41/18723 | 2.38e-04 | 1.79e-03 | 29 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRMT1L | SNV | Missense_Mutation | c.1510G>C | p.Glu504Gln | p.E504Q | Q7Z2T5 | protein_coding | tolerated(0.26) | benign(0.211) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
TRMT1L | SNV | Missense_Mutation | novel | c.880G>A | p.Ala294Thr | p.A294T | Q7Z2T5 | protein_coding | deleterious(0.04) | possibly_damaging(0.762) | TCGA-AC-A7VB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRMT1L | SNV | Missense_Mutation | c.340N>C | p.Asp114His | p.D114H | Q7Z2T5 | protein_coding | tolerated_low_confidence(0.24) | benign(0.204) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TRMT1L | insertion | Frame_Shift_Ins | novel | c.1119_1120insTCTGCCT | p.Pro374SerfsTer49 | p.P374Sfs*49 | Q7Z2T5 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRMT1L | insertion | Nonsense_Mutation | novel | c.1117_1118insCCTGGGCAACATAGTGAG | p.Leu372_Asp373insAlaTrpAlaThrTerTer | p.L372_D373insAWAT** | Q7Z2T5 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRMT1L | insertion | Frame_Shift_Ins | novel | c.737_738insAAAGGAGACCT | p.Thr248GlufsTer3 | p.T248Efs*3 | Q7Z2T5 | protein_coding | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | ||
TRMT1L | SNV | Missense_Mutation | c.1042C>T | p.Leu348Phe | p.L348F | Q7Z2T5 | protein_coding | tolerated(0.33) | benign(0.368) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRMT1L | SNV | Missense_Mutation | rs145284891 | c.614G>A | p.Arg205His | p.R205H | Q7Z2T5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRMT1L | SNV | Missense_Mutation | c.1702G>C | p.Glu568Gln | p.E568Q | Q7Z2T5 | protein_coding | tolerated(0.08) | benign(0.312) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
TRMT1L | SNV | Missense_Mutation | novel | c.569C>T | p.Ser190Leu | p.S190L | Q7Z2T5 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |