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Gene: TRIR |
Gene summary for TRIR |
Gene summary. |
Gene information | Species | Human | Gene symbol | TRIR | Gene ID | 79002 |
Gene name | telomerase RNA component interacting RNase | |
Gene Alias | C19orf43 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7EN60 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79002 | TRIR | GSM4909282 | Human | Breast | IDC | 3.84e-29 | 6.89e-01 | -0.0288 |
79002 | TRIR | GSM4909285 | Human | Breast | IDC | 7.51e-86 | 1.07e+00 | 0.21 |
79002 | TRIR | GSM4909286 | Human | Breast | IDC | 5.56e-17 | 3.10e-01 | 0.1081 |
79002 | TRIR | GSM4909290 | Human | Breast | IDC | 2.76e-06 | 3.92e-01 | 0.2096 |
79002 | TRIR | GSM4909291 | Human | Breast | IDC | 8.18e-15 | 6.06e-01 | 0.1753 |
79002 | TRIR | GSM4909293 | Human | Breast | IDC | 1.28e-11 | 3.02e-01 | 0.1581 |
79002 | TRIR | GSM4909296 | Human | Breast | IDC | 4.18e-08 | 2.62e-01 | 0.1524 |
79002 | TRIR | GSM4909297 | Human | Breast | IDC | 7.16e-04 | -1.22e-01 | 0.1517 |
79002 | TRIR | GSM4909298 | Human | Breast | IDC | 4.15e-15 | 4.80e-01 | 0.1551 |
79002 | TRIR | GSM4909299 | Human | Breast | IDC | 9.58e-05 | 3.15e-01 | 0.035 |
79002 | TRIR | GSM4909300 | Human | Breast | IDC | 2.14e-02 | 3.16e-01 | 0.0334 |
79002 | TRIR | GSM4909301 | Human | Breast | IDC | 2.57e-06 | 3.72e-01 | 0.1577 |
79002 | TRIR | GSM4909304 | Human | Breast | IDC | 1.71e-13 | 4.34e-01 | 0.1636 |
79002 | TRIR | GSM4909305 | Human | Breast | IDC | 4.08e-05 | 2.72e-01 | 0.0436 |
79002 | TRIR | GSM4909307 | Human | Breast | IDC | 1.34e-05 | 3.69e-01 | 0.1569 |
79002 | TRIR | GSM4909308 | Human | Breast | IDC | 3.68e-19 | 4.90e-01 | 0.158 |
79002 | TRIR | GSM4909309 | Human | Breast | IDC | 1.14e-02 | 3.17e-01 | 0.0483 |
79002 | TRIR | GSM4909311 | Human | Breast | IDC | 1.04e-22 | -1.61e-01 | 0.1534 |
79002 | TRIR | GSM4909312 | Human | Breast | IDC | 7.28e-13 | 3.00e-01 | 0.1552 |
79002 | TRIR | GSM4909313 | Human | Breast | IDC | 2.44e-03 | 3.16e-01 | 0.0391 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160726 | Breast | Precancer | rRNA metabolic process | 36/1080 | 236/18723 | 8.59e-08 | 4.84e-06 | 36 |
GO:00064018 | Breast | Precancer | RNA catabolic process | 34/1080 | 278/18723 | 2.88e-05 | 6.39e-04 | 34 |
GO:00346558 | Breast | Precancer | nucleobase-containing compound catabolic process | 42/1080 | 407/18723 | 1.91e-04 | 3.06e-03 | 42 |
GO:00467007 | Breast | Precancer | heterocycle catabolic process | 44/1080 | 445/18723 | 3.49e-04 | 4.88e-03 | 44 |
GO:00442708 | Breast | Precancer | cellular nitrogen compound catabolic process | 44/1080 | 451/18723 | 4.64e-04 | 6.12e-03 | 44 |
GO:00194397 | Breast | Precancer | aromatic compound catabolic process | 44/1080 | 467/18723 | 9.55e-04 | 1.07e-02 | 44 |
GO:00346604 | Breast | Precancer | ncRNA metabolic process | 45/1080 | 485/18723 | 1.15e-03 | 1.26e-02 | 45 |
GO:19013617 | Breast | Precancer | organic cyclic compound catabolic process | 45/1080 | 495/18723 | 1.73e-03 | 1.74e-02 | 45 |
GO:001607214 | Breast | IDC | rRNA metabolic process | 36/1434 | 236/18723 | 5.48e-05 | 1.17e-03 | 36 |
GO:000640113 | Breast | IDC | RNA catabolic process | 38/1434 | 278/18723 | 3.54e-04 | 5.16e-03 | 38 |
GO:190136112 | Breast | IDC | organic cyclic compound catabolic process | 56/1434 | 495/18723 | 2.12e-03 | 1.99e-02 | 56 |
GO:004670012 | Breast | IDC | heterocycle catabolic process | 51/1434 | 445/18723 | 2.51e-03 | 2.25e-02 | 51 |
GO:003465513 | Breast | IDC | nucleobase-containing compound catabolic process | 47/1434 | 407/18723 | 3.12e-03 | 2.63e-02 | 47 |
GO:004427012 | Breast | IDC | cellular nitrogen compound catabolic process | 50/1434 | 451/18723 | 5.29e-03 | 3.93e-02 | 50 |
GO:001943912 | Breast | IDC | aromatic compound catabolic process | 51/1434 | 467/18723 | 6.54e-03 | 4.59e-02 | 51 |
GO:001607222 | Breast | DCIS | rRNA metabolic process | 36/1390 | 236/18723 | 2.86e-05 | 6.42e-04 | 36 |
GO:000640123 | Breast | DCIS | RNA catabolic process | 38/1390 | 278/18723 | 1.91e-04 | 3.08e-03 | 38 |
GO:003465522 | Breast | DCIS | nucleobase-containing compound catabolic process | 47/1390 | 407/18723 | 1.69e-03 | 1.68e-02 | 47 |
GO:190136122 | Breast | DCIS | organic cyclic compound catabolic process | 55/1390 | 495/18723 | 1.75e-03 | 1.71e-02 | 55 |
GO:004670022 | Breast | DCIS | heterocycle catabolic process | 50/1390 | 445/18723 | 2.19e-03 | 2.03e-02 | 50 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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