Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TRIP6

Gene summary for TRIP6

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TRIP6

Gene ID

7205

Gene namethyroid hormone receptor interactor 6
Gene AliasOIP-1
Cytomap7q22.1
Gene Typeprotein-coding
GO ID

GO:0006928

UniProtAcc

Q15654


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7205TRIP6HTA11_3410_2000001011HumanColorectumAD1.19e-184.44e-010.0155
7205TRIP6HTA11_1938_2000001011HumanColorectumAD8.05e-063.18e-01-0.0811
7205TRIP6HTA11_78_2000001011HumanColorectumAD5.01e-134.98e-01-0.1088
7205TRIP6HTA11_3361_2000001011HumanColorectumAD3.34e-064.49e-01-0.1207
7205TRIP6HTA11_696_2000001011HumanColorectumAD1.45e-093.05e-01-0.1464
7205TRIP6HTA11_1391_2000001011HumanColorectumAD3.58e-217.68e-01-0.059
7205TRIP6HTA11_546_2000001011HumanColorectumAD2.53e-033.35e-01-0.0842
7205TRIP6HTA11_866_3004761011HumanColorectumAD2.32e-124.15e-010.096
7205TRIP6HTA11_8622_2000001021HumanColorectumSER7.72e-054.57e-010.0528
7205TRIP6HTA11_10711_2000001011HumanColorectumAD8.38e-114.62e-010.0338
7205TRIP6HTA11_7696_3000711011HumanColorectumAD4.28e-328.03e-010.0674
7205TRIP6HTA11_6818_2000001021HumanColorectumAD1.26e-126.30e-010.0588
7205TRIP6HTA11_99999970781_79442HumanColorectumMSS2.16e-184.96e-010.294
7205TRIP6HTA11_99999965104_69814HumanColorectumMSS2.57e-074.31e-010.281
7205TRIP6HTA11_99999973899_84307HumanColorectumMSS1.62e-146.87e-010.2585
7205TRIP6LZE2THumanEsophagusESCC9.09e-051.81e-010.082
7205TRIP6LZE4THumanEsophagusESCC4.36e-073.80e-020.0811
7205TRIP6LZE7THumanEsophagusESCC1.40e-066.58e-020.0667
7205TRIP6LZE8THumanEsophagusESCC7.43e-042.17e-010.067
7205TRIP6LZE20THumanEsophagusESCC7.60e-034.70e-020.0662
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0034329ColorectumADcell junction assembly136/3918420/187232.02e-081.15e-06136
GO:0150115ColorectumADcell-substrate junction organization44/3918101/187232.38e-079.81e-0644
GO:0031589ColorectumADcell-substrate adhesion116/3918363/187234.68e-071.76e-05116
GO:0007044ColorectumADcell-substrate junction assembly41/391895/187238.20e-072.85e-0541
GO:0007160ColorectumADcell-matrix adhesion75/3918233/187233.56e-056.45e-0475
GO:0048041ColorectumADfocal adhesion assembly34/391887/187238.30e-051.30e-0334
GO:00343291ColorectumSERcell junction assembly100/2897420/187234.23e-061.61e-04100
GO:01501151ColorectumSERcell-substrate junction organization34/2897101/187234.46e-061.67e-0434
GO:00070441ColorectumSERcell-substrate junction assembly31/289795/187232.34e-056.64e-0431
GO:00315891ColorectumSERcell-substrate adhesion86/2897363/187232.36e-056.64e-0486
GO:00480411ColorectumSERfocal adhesion assembly26/289787/187234.98e-047.08e-0326
GO:00071601ColorectumSERcell-matrix adhesion53/2897233/187232.10e-032.06e-0253
GO:00343292ColorectumMSScell junction assembly120/3467420/187232.51e-071.07e-05120
GO:00315892ColorectumMSScell-substrate adhesion104/3467363/187231.35e-064.51e-05104
GO:01501152ColorectumMSScell-substrate junction organization39/3467101/187231.74e-065.60e-0539
GO:00070442ColorectumMSScell-substrate junction assembly36/346795/187237.10e-061.82e-0436
GO:00071602ColorectumMSScell-matrix adhesion65/3467233/187232.77e-043.67e-0365
GO:00480412ColorectumMSSfocal adhesion assembly29/346787/187236.84e-047.37e-0329
GO:015011519EsophagusHGINcell-substrate junction organization24/2587101/187234.85e-034.16e-0224
GO:19012247EsophagusHGINpositive regulation of NIK/NF-kappaB signaling18/258769/187234.94e-034.18e-0218
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa046219EsophagusHGINNOD-like receptor signaling pathway45/1383186/84653.40e-032.54e-022.02e-0245
hsa0462114EsophagusHGINNOD-like receptor signaling pathway45/1383186/84653.40e-032.54e-022.02e-0245
hsa0462122EsophagusESCCNOD-like receptor signaling pathway116/4205186/84652.90e-041.03e-035.30e-04116
hsa0462132EsophagusESCCNOD-like receptor signaling pathway116/4205186/84652.90e-041.03e-035.30e-04116
hsa046218Oral cavityOSCCNOD-like receptor signaling pathway108/3704186/84655.13e-052.07e-041.05e-04108
hsa0462113Oral cavityOSCCNOD-like receptor signaling pathway108/3704186/84655.13e-052.07e-041.05e-04108
hsa0462121Oral cavityLPNOD-like receptor signaling pathway73/2418186/84659.80e-044.53e-032.92e-0373
hsa0462131Oral cavityLPNOD-like receptor signaling pathway73/2418186/84659.80e-044.53e-032.92e-0373
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TRIP6SNVMissense_Mutationnovelc.1276N>Tp.His426Tyrp.H426YQ15654protein_codingdeleterious(0)probably_damaging(1)TCGA-A2-A3Y0-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
TRIP6SNVMissense_Mutationrs750780514c.892N>Tp.Arg298Cysp.R298CQ15654protein_codingdeleterious(0)probably_damaging(0.978)TCGA-AN-A041-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TRIP6SNVMissense_Mutationnovelc.778A>Gp.Thr260Alap.T260AQ15654protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AO-A0J9-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamidePD
TRIP6SNVMissense_Mutationrs748260838c.1384N>Ap.Ala462Thrp.A462TQ15654protein_codingtolerated(0.16)possibly_damaging(0.67)TCGA-E9-A1RE-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapytamoxiphenSD
TRIP6SNVMissense_Mutationc.1322C>Tp.Ser441Phep.S441FQ15654protein_codingdeleterious(0)probably_damaging(1)TCGA-C5-A1MH-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinPD
TRIP6SNVMissense_Mutationrs371631775c.341N>Tp.Ala114Valp.A114VQ15654protein_codingtolerated(0.14)benign(0.003)TCGA-A6-2686-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
TRIP6SNVMissense_Mutationrs778782117c.893G>Ap.Arg298Hisp.R298HQ15654protein_codingdeleterious(0.01)probably_damaging(0.97)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
TRIP6SNVMissense_Mutationrs139848707c.1111N>Ap.Gly371Serp.G371SQ15654protein_codingtolerated(1)benign(0.01)TCGA-A6-A565-01Colorectumcolon adenocarcinomaFemale<65III/IVUnspecific5FUPD
TRIP6SNVMissense_Mutationc.1019N>Tp.Ala340Valp.A340VQ15654protein_codingdeleterious(0.01)benign(0.027)TCGA-AD-5900-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
TRIP6SNVMissense_Mutationrs770472424c.1100N>Cp.Val367Alap.V367AQ15654protein_codingdeleterious(0.04)benign(0.148)TCGA-AY-6197-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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