Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TRIM71

Gene summary for TRIM71

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TRIM71

Gene ID

131405

Gene nametripartite motif containing 71
Gene AliasHYDCC1
Cytomap3p22.3
Gene Typeprotein-coding
GO ID

GO:0000082

UniProtAcc

Q2Q1W2


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
131405TRIM71HCC1_MengHumanLiverHCC9.66e-391.87e-010.0246
131405TRIM71HCC1HumanLiverHCC5.09e-082.37e+000.5336
131405TRIM71HCC2HumanLiverHCC1.30e-153.34e+000.5341
131405TRIM71Pt14.aHumanLiverHCC6.65e-083.05e-010.0169
131405TRIM71S014HumanLiverHCC2.64e-072.40e-010.2254
131405TRIM71S015HumanLiverHCC2.91e-144.85e-010.2375
131405TRIM71S016HumanLiverHCC3.39e-082.35e-010.2243
131405TRIM71S028HumanLiverHCC1.64e-051.79e-010.2503
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001049822LiverHCCproteasomal protein catabolic process351/7958490/187236.92e-401.46e-36351
GO:004316122LiverHCCproteasome-mediated ubiquitin-dependent protein catabolic process299/7958412/187237.82e-368.27e-33299
GO:00346601LiverHCCncRNA metabolic process332/7958485/187231.48e-317.80e-29332
GO:000989622LiverHCCpositive regulation of catabolic process335/7958492/187233.83e-311.87e-28335
GO:003133122LiverHCCpositive regulation of cellular catabolic process295/7958427/187233.20e-291.45e-26295
GO:004427021LiverHCCcellular nitrogen compound catabolic process303/7958451/187239.76e-273.64e-24303
GO:004670021LiverHCCheterocycle catabolic process299/7958445/187232.07e-267.29e-24299
GO:190136121LiverHCCorganic cyclic compound catabolic process325/7958495/187236.52e-262.18e-23325
GO:001943921LiverHCCaromatic compound catabolic process309/7958467/187231.56e-254.94e-23309
GO:000640121LiverHCCRNA catabolic process201/7958278/187233.88e-241.02e-21201
GO:003465521LiverHCCnucleobase-containing compound catabolic process273/7958407/187234.84e-241.23e-21273
GO:190331121LiverHCCregulation of mRNA metabolic process205/7958288/187233.38e-236.90e-21205
GO:000640221LiverHCCmRNA catabolic process169/7958232/187234.50e-216.96e-19169
GO:000641722LiverHCCregulation of translation287/7958468/187238.79e-178.08e-15287
GO:004348721LiverHCCregulation of RNA stability119/7958170/187233.20e-131.71e-11119
GO:004348821LiverHCCregulation of mRNA stability110/7958158/187234.36e-121.93e-10110
GO:006101321LiverHCCregulation of mRNA catabolic process114/7958166/187237.38e-123.12e-10114
GO:000020921LiverHCCprotein polyubiquitination151/7958236/187231.90e-117.59e-10151
GO:190331321LiverHCCpositive regulation of mRNA metabolic process85/7958118/187237.10e-112.56e-0985
GO:00447722LiverHCCmitotic cell cycle phase transition240/7958424/187232.47e-096.84e-08240
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TRIM71SNVMissense_Mutationc.1515N>Ap.Phe505Leup.F505LQ2Q1W2protein_codingdeleterious(0.04)possibly_damaging(0.814)TCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
TRIM71SNVMissense_Mutationnovelc.1218N>Cp.Gln406Hisp.Q406HQ2Q1W2protein_codingdeleterious(0.03)probably_damaging(0.993)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRIM71SNVMissense_Mutationnovelc.1220N>Cp.Asn407Thrp.N407TQ2Q1W2protein_codingtolerated(0.48)benign(0.01)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRIM71SNVMissense_Mutationnovelc.2460G>Tp.Met820Ilep.M820IQ2Q1W2protein_codingtolerated(0.56)benign(0)TCGA-B6-A0IM-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRIM71SNVMissense_Mutationc.2536G>Ap.Gly846Serp.G846SQ2Q1W2protein_codingdeleterious(0.01)probably_damaging(0.948)TCGA-E2-A156-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
TRIM71insertionFrame_Shift_Insnovelc.1678_1679insGp.His560ArgfsTer13p.H560Rfs*13Q2Q1W2protein_codingTCGA-A2-A0EM-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
TRIM71insertionFrame_Shift_Insnovelc.1679_1680insAGACCGTGCGGAGCCTp.His560GlnfsTer18p.H560Qfs*18Q2Q1W2protein_codingTCGA-A2-A0EM-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
TRIM71insertionNonsense_Mutationnovelc.1155_1155+1insATCTCTTAATAGTTCTGACATTCACTGTp.Val386IlefsTer3p.V386Ifs*3Q2Q1W2protein_codingTCGA-A8-A08Z-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
TRIM71deletionFrame_Shift_Delnovelc.1211delNp.Leu404ArgfsTer25p.L404Rfs*25Q2Q1W2protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
TRIM71deletionFrame_Shift_Delnovelc.1606delNp.Phe536LeufsTer5p.F536Lfs*5Q2Q1W2protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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