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Gene: TRIM66 |
Gene summary for TRIM66 |
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Gene information | Species | Human | Gene symbol | TRIM66 | Gene ID | 9866 |
Gene name | tripartite motif containing 66 | |
Gene Alias | C11orf29 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O15016 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9866 | TRIM66 | NAFLD1 | Human | Liver | NAFLD | 1.11e-06 | 7.03e-01 | -0.04 |
9866 | TRIM66 | HCC1_Meng | Human | Liver | HCC | 1.70e-17 | -6.98e-02 | 0.0246 |
9866 | TRIM66 | HCC2_Meng | Human | Liver | HCC | 7.87e-04 | -7.07e-02 | 0.0107 |
9866 | TRIM66 | HCC2 | Human | Liver | HCC | 1.43e-08 | 1.87e+00 | 0.5341 |
9866 | TRIM66 | HCC5 | Human | Liver | HCC | 1.11e-02 | 1.38e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM66 | SNV | Missense_Mutation | c.2980N>T | p.Ala994Ser | p.A994S | protein_coding | tolerated(0.59) | benign(0.003) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | ||
TRIM66 | SNV | Missense_Mutation | novel | c.1415N>A | p.Pro472His | p.P472H | protein_coding | tolerated(0.05) | possibly_damaging(0.498) | TCGA-AN-A0FF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRIM66 | SNV | Missense_Mutation | c.232N>C | p.Glu78Gln | p.E78Q | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A24L-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | PD | ||
TRIM66 | deletion | Frame_Shift_Del | novel | c.1704delN | p.Gln569ArgfsTer53 | p.Q569Rfs*53 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
TRIM66 | SNV | Missense_Mutation | novel | c.2323N>G | p.Thr775Ala | p.T775A | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRIM66 | SNV | Missense_Mutation | rs373726386 | c.538N>T | p.Arg180Trp | p.R180W | protein_coding | deleterious(0) | possibly_damaging(0.53) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRIM66 | SNV | Missense_Mutation | novel | c.889N>G | p.Gln297Glu | p.Q297E | protein_coding | deleterious(0.02) | benign(0.046) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRIM66 | SNV | Missense_Mutation | novel | c.818N>A | p.Ala273Glu | p.A273E | protein_coding | deleterious(0.04) | benign(0.069) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TRIM66 | SNV | Missense_Mutation | novel | c.305N>G | p.Val102Gly | p.V102G | protein_coding | deleterious(0.01) | possibly_damaging(0.49) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TRIM66 | SNV | Missense_Mutation | novel | c.2006C>G | p.Pro669Arg | p.P669R | protein_coding | tolerated(0.1) | benign(0.132) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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