Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TRIM46

Gene summary for TRIM46

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TRIM46

Gene ID

80128

Gene nametripartite motif containing 46
Gene AliasGENEY
Cytomap1q22
Gene Typeprotein-coding
GO ID

GO:0000226

UniProtAcc

Q7Z4K8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
80128TRIM46HCC1HumanLiverHCC1.89e-025.08e-010.5336
80128TRIM46HCC2HumanLiverHCC3.10e-115.99e-010.5341
80128TRIM46HCC5HumanLiverHCC1.23e-096.05e-010.4932
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003238621LiverHCCregulation of intracellular transport231/7958337/187231.99e-223.40e-20231
GO:003238821LiverHCCpositive regulation of intracellular transport148/7958202/187235.15e-196.66e-17148
GO:001648221LiverHCCcytosolic transport117/7958168/187238.83e-134.48e-11117
GO:005165621LiverHCCestablishment of organelle localization226/7958390/187234.15e-101.34e-08226
GO:001604921LiverHCCcell growth269/7958482/187231.84e-095.35e-08269
GO:003253522LiverHCCregulation of cellular component size217/7958383/187231.28e-083.14e-07217
GO:005165021LiverHCCestablishment of vesicle localization103/7958161/187232.94e-086.69e-07103
GO:000155821LiverHCCregulation of cell growth228/7958414/187231.34e-072.55e-06228
GO:19036493LiverHCCregulation of cytoplasmic transport25/795828/187233.42e-075.88e-0625
GO:005164821LiverHCCvesicle localization107/7958177/187231.05e-061.57e-05107
GO:00080882LiverHCCaxo-dendritic transport52/795875/187232.34e-063.14e-0552
GO:00723843LiverHCCorganelle transport along microtubule56/795885/187231.13e-051.29e-0456
GO:003070521LiverHCCcytoskeleton-dependent intracellular transport111/7958195/187233.25e-053.28e-04111
GO:0047496LiverHCCvesicle transport along microtubule34/795847/187233.27e-053.29e-0434
GO:0098930LiverHCCaxonal transport43/795864/187235.73e-055.31e-0443
GO:00109702LiverHCCtransport along microtubule90/7958155/187236.49e-055.92e-0490
GO:1903651LiverHCCpositive regulation of cytoplasmic transport12/795813/187232.73e-041.98e-0312
GO:00995182LiverHCCvesicle cytoskeletal trafficking46/795873/187233.23e-042.28e-0346
GO:006056011LiverHCCdevelopmental growth involved in morphogenesis124/7958234/187237.37e-044.47e-03124
GO:001097511LiverHCCregulation of neuron projection development220/7958445/187231.68e-038.78e-03220
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TRIM46SNVMissense_Mutationc.1057N>Tp.His353Tyrp.H353YQ7Z4K8protein_codingtolerated(1)benign(0.003)TCGA-A8-A09A-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
TRIM46SNVMissense_Mutationc.1499C>Tp.Ser500Phep.S500FQ7Z4K8protein_codingdeleterious(0)probably_damaging(0.947)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
TRIM46SNVMissense_Mutationc.542N>Gp.Glu181Glyp.E181GQ7Z4K8protein_codingdeleterious(0)probably_damaging(0.99)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
TRIM46SNVMissense_Mutationc.1903G>Tp.Gly635Trpp.G635WQ7Z4K8protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
TRIM46SNVMissense_Mutationnovelc.1630N>Cp.Glu544Glnp.E544QQ7Z4K8protein_codingdeleterious(0.02)possibly_damaging(0.856)TCGA-E2-A1LE-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapyherceptinPD
TRIM46SNVMissense_Mutationnovelc.1315N>Tp.Arg439Cysp.R439CQ7Z4K8protein_codingdeleterious(0.03)possibly_damaging(0.786)TCGA-PL-A8LZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapypaclitaxelSD
TRIM46deletionFrame_Shift_Delnovelc.2104delGp.Val702PhefsTer112p.V702Ffs*112Q7Z4K8protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
TRIM46SNVMissense_Mutationnovelc.1628G>Ap.Arg543Glnp.R543QQ7Z4K8protein_codingtolerated(0.49)benign(0.259)TCGA-C5-A1M7-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TRIM46SNVMissense_Mutationnovelc.2041N>Tp.Ala681Serp.A681SQ7Z4K8protein_codingtolerated(0.77)benign(0.304)TCGA-C5-A8YQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
TRIM46SNVMissense_Mutationnovelc.116N>Ap.Met39Lysp.M39KQ7Z4K8protein_codingdeleterious(0)possibly_damaging(0.745)TCGA-VS-A9UM-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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