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Gene: TRIM31-AS1 |
Gene summary for TRIM31-AS1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TRIM31-AS1 | Gene ID | 104533120 |
| Gene name | TRIM31 antisense RNA 1 | |
| Gene Alias | TRIM31-AS1 | |
| Cytomap | 6p22.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 104533120 | TRIM31-AS1 | Pat01-B | Human | Stomach | GC | 1.08e-17 | 4.03e-01 | 0.5754 |
| 104533120 | TRIM31-AS1 | Pat02-B | Human | Stomach | GC | 3.92e-18 | 3.29e-01 | 0.0368 |
| 104533120 | TRIM31-AS1 | Pat03-B | Human | Stomach | GC | 4.45e-05 | 1.52e-01 | 0.3693 |
| 104533120 | TRIM31-AS1 | Pat04-B | Human | Stomach | GC | 4.99e-06 | 1.80e-01 | -0.1483 |
| 104533120 | TRIM31-AS1 | Pat06-B | Human | Stomach | GC | 6.82e-16 | 3.02e-01 | -0.1961 |
| 104533120 | TRIM31-AS1 | Pat07-B | Human | Stomach | GC | 3.46e-05 | 2.94e-01 | 0.0935 |
| 104533120 | TRIM31-AS1 | Pat09-B | Human | Stomach | GC | 9.02e-11 | 3.24e-01 | -0.0359 |
| 104533120 | TRIM31-AS1 | Pat10-B | Human | Stomach | GC | 1.73e-04 | 3.15e-01 | 0.084 |
| 104533120 | TRIM31-AS1 | Pat11-B | Human | Stomach | GC | 2.17e-06 | 2.33e-01 | -0.182 |
| 104533120 | TRIM31-AS1 | Pat13-B | Human | Stomach | GC | 9.64e-05 | 1.70e-01 | 0.0555 |
| 104533120 | TRIM31-AS1 | Pat15-B | Human | Stomach | GC | 1.77e-05 | 1.85e-01 | -0.0778 |
| 104533120 | TRIM31-AS1 | Pat16-B | Human | Stomach | GC | 1.91e-10 | 3.46e-01 | 0.1918 |
| 104533120 | TRIM31-AS1 | Pat17-B | Human | Stomach | GC | 1.91e-10 | 3.01e-01 | 0.3109 |
| 104533120 | TRIM31-AS1 | Pat18-B | Human | Stomach | GC | 6.60e-08 | 2.32e-01 | -0.0432 |
| 104533120 | TRIM31-AS1 | Pat22-B | Human | Stomach | GC | 8.64e-17 | 3.33e-01 | -0.1042 |
| 104533120 | TRIM31-AS1 | Pat24-B | Human | Stomach | GC | 6.84e-09 | 2.98e-01 | -0.1184 |
| 104533120 | TRIM31-AS1 | Pat25-A | Human | Stomach | CAG with IM | 9.31e-09 | 1.72e-01 | -0.1648 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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