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Gene: TRIAP1 |
Gene summary for TRIAP1 |
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Gene information | Species | Human | Gene symbol | TRIAP1 | Gene ID | 51499 |
Gene name | TP53 regulated inhibitor of apoptosis 1 | |
Gene Alias | HSPC132 | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | O43715 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51499 | TRIAP1 | LZE4T | Human | Esophagus | ESCC | 7.44e-09 | 2.53e-01 | 0.0811 |
51499 | TRIAP1 | LZE7T | Human | Esophagus | ESCC | 5.02e-05 | 6.95e-01 | 0.0667 |
51499 | TRIAP1 | LZE8T | Human | Esophagus | ESCC | 4.80e-10 | 4.74e-01 | 0.067 |
51499 | TRIAP1 | LZE20T | Human | Esophagus | ESCC | 3.99e-02 | 4.79e-02 | 0.0662 |
51499 | TRIAP1 | LZE24T | Human | Esophagus | ESCC | 5.53e-10 | 3.34e-01 | 0.0596 |
51499 | TRIAP1 | LZE6T | Human | Esophagus | ESCC | 2.19e-06 | 4.02e-01 | 0.0845 |
51499 | TRIAP1 | P1T-E | Human | Esophagus | ESCC | 1.20e-03 | 4.28e-01 | 0.0875 |
51499 | TRIAP1 | P2T-E | Human | Esophagus | ESCC | 2.68e-67 | 1.35e+00 | 0.1177 |
51499 | TRIAP1 | P4T-E | Human | Esophagus | ESCC | 5.37e-21 | 7.26e-01 | 0.1323 |
51499 | TRIAP1 | P5T-E | Human | Esophagus | ESCC | 1.92e-17 | 2.89e-01 | 0.1327 |
51499 | TRIAP1 | P8T-E | Human | Esophagus | ESCC | 1.86e-28 | 6.16e-01 | 0.0889 |
51499 | TRIAP1 | P9T-E | Human | Esophagus | ESCC | 2.77e-09 | 1.93e-01 | 0.1131 |
51499 | TRIAP1 | P10T-E | Human | Esophagus | ESCC | 3.03e-38 | 5.22e-01 | 0.116 |
51499 | TRIAP1 | P11T-E | Human | Esophagus | ESCC | 4.89e-18 | 6.20e-01 | 0.1426 |
51499 | TRIAP1 | P12T-E | Human | Esophagus | ESCC | 8.97e-25 | 4.24e-01 | 0.1122 |
51499 | TRIAP1 | P15T-E | Human | Esophagus | ESCC | 4.94e-15 | 3.98e-01 | 0.1149 |
51499 | TRIAP1 | P16T-E | Human | Esophagus | ESCC | 5.77e-45 | 6.34e-01 | 0.1153 |
51499 | TRIAP1 | P17T-E | Human | Esophagus | ESCC | 2.01e-08 | 5.06e-01 | 0.1278 |
51499 | TRIAP1 | P19T-E | Human | Esophagus | ESCC | 2.52e-07 | 7.50e-01 | 0.1662 |
51499 | TRIAP1 | P20T-E | Human | Esophagus | ESCC | 8.67e-26 | 5.17e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
GO:0072331111 | Esophagus | ESCC | signal transduction by p53 class mediator | 121/8552 | 163/18723 | 9.61e-14 | 4.69e-12 | 121 |
GO:0010821110 | Esophagus | ESCC | regulation of mitochondrion organization | 107/8552 | 144/18723 | 2.31e-12 | 9.41e-11 | 107 |
GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
GO:0008630110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to DNA damage | 78/8552 | 99/18723 | 1.43e-11 | 5.08e-10 | 78 |
GO:0008637110 | Esophagus | ESCC | apoptotic mitochondrial changes | 83/8552 | 107/18723 | 1.43e-11 | 5.08e-10 | 83 |
GO:2000116111 | Esophagus | ESCC | regulation of cysteine-type endopeptidase activity | 158/8552 | 235/18723 | 1.67e-11 | 5.90e-10 | 158 |
GO:0043281111 | Esophagus | ESCC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 143/8552 | 209/18723 | 2.12e-11 | 7.31e-10 | 143 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:003464413 | Esophagus | ESCC | cellular response to UV | 70/8552 | 90/18723 | 4.59e-10 | 1.20e-08 | 70 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIAP1 | insertion | Nonsense_Mutation | novel | c.25_26insAAGGAGAAAGAGATTCCTATTGAAGG | p.Thr9LysfsTer8 | p.T9Kfs*8 | O43715 | protein_coding | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
TRIAP1 | SNV | Missense_Mutation | c.25A>G | p.Thr9Ala | p.T9A | O43715 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TRIAP1 | insertion | In_Frame_Ins | novel | c.40_41insTAA | p.Glu14delinsValLys | p.E14delinsVK | O43715 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TRIAP1 | SNV | Missense_Mutation | novel | c.224C>A | p.Ser75Tyr | p.S75Y | O43715 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRIAP1 | SNV | Missense_Mutation | novel | c.61C>T | p.Arg21Cys | p.R21C | O43715 | protein_coding | tolerated(0.19) | benign(0.019) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIAP1 | SNV | Missense_Mutation | c.53N>C | p.Cys18Ser | p.C18S | O43715 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
TRIAP1 | SNV | Missense_Mutation | novel | c.58N>C | p.Asn20His | p.N20H | O43715 | protein_coding | deleterious(0.05) | probably_damaging(0.947) | TCGA-66-2769-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TRIAP1 | SNV | Missense_Mutation | novel | c.178N>A | p.Glu60Lys | p.E60K | O43715 | protein_coding | tolerated(0.42) | benign(0.197) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TRIAP1 | SNV | Missense_Mutation | c.154N>G | p.Ile52Val | p.I52V | O43715 | protein_coding | tolerated(0.16) | benign(0.197) | TCGA-HU-8243-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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