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Gene: TRDC |
Gene summary for TRDC |
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Gene information | Species | Human | Gene symbol | TRDC | Gene ID | 28526 |
Gene name | T cell receptor delta constant | |
Gene Alias | TCRD | |
Cytomap | 14q11.2 | |
Gene Type | other | GO ID | GO:0001775 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28526 | TRDC | cirrhotic2 | Human | Liver | Cirrhotic | 5.76e-03 | -1.90e-02 | 0.0201 |
28526 | TRDC | S014 | Human | Liver | HCC | 2.40e-16 | 1.13e+00 | 0.2254 |
28526 | TRDC | S015 | Human | Liver | HCC | 2.15e-07 | 6.62e-01 | 0.2375 |
28526 | TRDC | S016 | Human | Liver | HCC | 2.04e-14 | 8.94e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRDC | SNV | Missense_Mutation | novel | c.303N>A | p.Glu102Lys | p.E102K | TR_C_gene | tolerated(0.62) | benign(0.009) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | rs759332805 | c.105N>A | p.Val36Met | p.V36M | TR_C_gene | tolerated(0.08) | benign(0.232) | TCGA-AR-A2LL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TRDC | SNV | Missense_Mutation | novel | c.430A>C | p.Asn144Thr | p.N144T | TR_C_gene | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.337N>T | p.Lys113Ile | p.K113I | TR_C_gene | deleterious(0.04) | benign(0.127) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.116G>T | p.Lys39Asn | p.K39N | TR_C_gene | tolerated(0.2) | benign(0.027) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.262N>A | p.Val88Glu | p.V88E | TR_C_gene | tolerated(1) | benign(0.005) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TRDC | SNV | Missense_Mutation | novel | c.348A>G | p.Ile117Val | p.I117V | TR_C_gene | tolerated(0.57) | benign(0) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.89T>A | p.Asp30Glu | p.D30E | TR_C_gene | tolerated(0.21) | benign(0.013) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.256T>C | p.Phe86Ser | p.F86S | TR_C_gene | tolerated(0.15) | possibly_damaging(0.576) | TCGA-66-2780-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRDC | SNV | Missense_Mutation | novel | c.357N>G | p.Thr120Ala | p.T120A | TR_C_gene | tolerated(0.52) | benign(0) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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