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Gene: TRAPPC2B |
Gene summary for TRAPPC2B |
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Gene information | Species | Human | Gene symbol | TRAPPC2B | Gene ID | 10597 |
Gene name | trafficking protein particle complex subunit 2B | |
Gene Alias | MIP-2A | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10597 | TRAPPC2B | S014 | Human | Liver | HCC | 1.45e-07 | 3.02e-01 | 0.2254 |
10597 | TRAPPC2B | S015 | Human | Liver | HCC | 1.75e-20 | 6.55e-01 | 0.2375 |
10597 | TRAPPC2B | S016 | Human | Liver | HCC | 3.82e-10 | 3.81e-01 | 0.2243 |
10597 | TRAPPC2B | S027 | Human | Liver | HCC | 1.12e-04 | 3.79e-01 | 0.2446 |
10597 | TRAPPC2B | S028 | Human | Liver | HCC | 6.65e-06 | 3.12e-01 | 0.2503 |
10597 | TRAPPC2B | S029 | Human | Liver | HCC | 4.18e-13 | 5.24e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAPPC2B | SNV | Missense_Mutation | novel | c.243N>A | p.Met81Ile | p.M81I | P0DI82 | protein_coding | tolerated(0.99) | benign(0) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC2B | SNV | Missense_Mutation | c.183G>C | p.Leu61Phe | p.L61F | P0DI82 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-BH-A18J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
TRAPPC2B | SNV | Missense_Mutation | rs759992941 | c.17A>G | p.Tyr6Cys | p.Y6C | P0DI82 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC2B | SNV | Missense_Mutation | c.205N>A | p.Glu69Lys | p.E69K | P0DI82 | protein_coding | tolerated(0.15) | probably_damaging(0.932) | TCGA-A6-6138-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRAPPC2B | SNV | Missense_Mutation | novel | c.248T>A | p.Phe83Tyr | p.F83Y | P0DI82 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
TRAPPC2B | SNV | Missense_Mutation | novel | c.94G>T | p.Asp32Tyr | p.D32Y | P0DI82 | protein_coding | deleterious(0) | possibly_damaging(0.657) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRAPPC2B | SNV | Missense_Mutation | novel | c.11G>T | p.Ser4Ile | p.S4I | P0DI82 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRAPPC2B | SNV | Missense_Mutation | c.125N>A | p.Ala42Asp | p.A42D | P0DI82 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRAPPC2B | SNV | Missense_Mutation | novel | c.401G>A | p.Gly134Glu | p.G134E | P0DI82 | protein_coding | deleterious(0) | possibly_damaging(0.496) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC2B | SNV | Missense_Mutation | c.365N>A | p.Arg122Gln | p.R122Q | P0DI82 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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