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Gene: TPRN |
Gene summary for TPRN |
Gene summary. |
Gene information | Species | Human | Gene symbol | TPRN | Gene ID | 286262 |
Gene name | taperin | |
Gene Alias | C9orf75 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q4KMQ1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
286262 | TPRN | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.43e-06 | 3.07e-01 | -0.1808 |
286262 | TPRN | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-05 | 2.18e-01 | -0.1954 |
286262 | TPRN | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.20e-05 | 3.28e-01 | -0.1207 |
286262 | TPRN | HTA11_696_2000001011 | Human | Colorectum | AD | 1.10e-06 | 3.23e-01 | -0.1464 |
286262 | TPRN | HTA11_866_2000001011 | Human | Colorectum | AD | 1.35e-02 | 1.79e-01 | -0.1001 |
286262 | TPRN | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.77e-10 | 4.79e-01 | -0.059 |
286262 | TPRN | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.95e-07 | 2.68e-01 | 0.0674 |
286262 | TPRN | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.50e-06 | 1.75e-01 | 0.3859 |
286262 | TPRN | HCC1_Meng | Human | Liver | HCC | 1.25e-25 | 4.96e-02 | 0.0246 |
286262 | TPRN | HCC2_Meng | Human | Liver | HCC | 7.11e-08 | 8.02e-02 | 0.0107 |
286262 | TPRN | HCC2 | Human | Liver | HCC | 1.46e-03 | 3.10e+00 | 0.5341 |
286262 | TPRN | S027 | Human | Liver | HCC | 9.53e-04 | 3.65e-01 | 0.2446 |
286262 | TPRN | S028 | Human | Liver | HCC | 5.73e-09 | 5.32e-01 | 0.2503 |
286262 | TPRN | S029 | Human | Liver | HCC | 6.37e-15 | 7.18e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
GO:0009746 | Colorectum | AD | response to hexose | 73/3918 | 219/18723 | 1.20e-05 | 2.65e-04 | 73 |
GO:0009749 | Colorectum | AD | response to glucose | 71/3918 | 212/18723 | 1.31e-05 | 2.85e-04 | 71 |
GO:0042593 | Colorectum | AD | glucose homeostasis | 83/3918 | 258/18723 | 1.44e-05 | 3.11e-04 | 83 |
GO:0001678 | Colorectum | AD | cellular glucose homeostasis | 60/3918 | 172/18723 | 1.49e-05 | 3.18e-04 | 60 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0071322 | Colorectum | AD | cellular response to carbohydrate stimulus | 56/3918 | 163/18723 | 4.61e-05 | 7.97e-04 | 56 |
GO:0071333 | Colorectum | AD | cellular response to glucose stimulus | 52/3918 | 151/18723 | 7.88e-05 | 1.25e-03 | 52 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0071331 | Colorectum | AD | cellular response to hexose stimulus | 52/3918 | 153/18723 | 1.16e-04 | 1.71e-03 | 52 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071326 | Colorectum | AD | cellular response to monosaccharide stimulus | 52/3918 | 154/18723 | 1.40e-04 | 1.98e-03 | 52 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPRN | deletion | Frame_Shift_Del | novel | c.1947delN | p.Leu650CysfsTer110 | p.L650Cfs*110 | Q4KMQ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TPRN | deletion | Frame_Shift_Del | novel | c.1490delN | p.Gly497AlafsTer46 | p.G497Afs*46 | Q4KMQ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TPRN | SNV | Missense_Mutation | novel | c.1651N>C | p.Glu551Gln | p.E551Q | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | c.944T>C | p.Leu315Pro | p.L315P | Q4KMQ1 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-EA-A78R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TPRN | SNV | Missense_Mutation | c.1876N>C | p.Glu626Gln | p.E626Q | Q4KMQ1 | protein_coding | tolerated(0.19) | possibly_damaging(0.686) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TPRN | SNV | Missense_Mutation | c.1657G>A | p.Glu553Lys | p.E553K | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD | |
TPRN | SNV | Missense_Mutation | rs749999995 | c.863N>T | p.Ser288Phe | p.S288F | Q4KMQ1 | protein_coding | deleterious(0) | possibly_damaging(0.795) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | rs754397078 | c.1819N>C | p.Glu607Gln | p.E607Q | Q4KMQ1 | protein_coding | deleterious(0.05) | possibly_damaging(0.829) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TPRN | SNV | Missense_Mutation | c.974N>G | p.Ala325Gly | p.A325G | Q4KMQ1 | protein_coding | deleterious(0) | benign(0.067) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TPRN | SNV | Missense_Mutation | c.914C>T | p.Pro305Leu | p.P305L | Q4KMQ1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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