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Gene: TPRG1 |
Gene summary for TPRG1 |
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Gene information | Species | Human | Gene symbol | TPRG1 | Gene ID | 285386 |
Gene name | tumor protein p63 regulated 1 | |
Gene Alias | FAM79B | |
Cytomap | 3q28 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6ZUI0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285386 | TPRG1 | GSM4909302 | Human | Breast | IDC | 2.39e-05 | 2.82e-01 | 0.1545 |
285386 | TPRG1 | GSM4909304 | Human | Breast | IDC | 1.07e-10 | 3.15e-01 | 0.1636 |
285386 | TPRG1 | GSM4909307 | Human | Breast | IDC | 1.18e-17 | 5.45e-01 | 0.1569 |
285386 | TPRG1 | GSM4909308 | Human | Breast | IDC | 7.10e-67 | 1.06e+00 | 0.158 |
285386 | TPRG1 | M5 | Human | Breast | IDC | 3.53e-25 | 1.20e+00 | 0.1598 |
285386 | TPRG1 | P3 | Human | Breast | IDC | 5.13e-15 | 9.68e-01 | 0.1542 |
285386 | TPRG1 | LZE4T | Human | Esophagus | ESCC | 2.80e-06 | 1.95e-01 | 0.0811 |
285386 | TPRG1 | LZE7T | Human | Esophagus | ESCC | 1.43e-05 | 5.03e-01 | 0.0667 |
285386 | TPRG1 | LZE8T | Human | Esophagus | ESCC | 1.27e-03 | 1.83e-01 | 0.067 |
285386 | TPRG1 | LZE20T | Human | Esophagus | ESCC | 2.23e-02 | 3.53e-01 | 0.0662 |
285386 | TPRG1 | LZE24T | Human | Esophagus | ESCC | 1.30e-14 | 5.27e-01 | 0.0596 |
285386 | TPRG1 | P2T-E | Human | Esophagus | ESCC | 4.99e-10 | 3.10e-01 | 0.1177 |
285386 | TPRG1 | P4T-E | Human | Esophagus | ESCC | 1.10e-10 | 2.86e-01 | 0.1323 |
285386 | TPRG1 | P5T-E | Human | Esophagus | ESCC | 1.14e-07 | 3.22e-01 | 0.1327 |
285386 | TPRG1 | P8T-E | Human | Esophagus | ESCC | 4.86e-11 | 3.91e-01 | 0.0889 |
285386 | TPRG1 | P9T-E | Human | Esophagus | ESCC | 1.74e-04 | 1.65e-01 | 0.1131 |
285386 | TPRG1 | P10T-E | Human | Esophagus | ESCC | 2.37e-15 | 3.53e-01 | 0.116 |
285386 | TPRG1 | P11T-E | Human | Esophagus | ESCC | 3.80e-03 | 3.84e-01 | 0.1426 |
285386 | TPRG1 | P12T-E | Human | Esophagus | ESCC | 1.69e-04 | 2.40e-01 | 0.1122 |
285386 | TPRG1 | P15T-E | Human | Esophagus | ESCC | 2.25e-12 | 3.48e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TPRG1 | SNV | Missense_Mutation | rs200541402 | c.809N>A | p.Arg270His | p.R270H | Q6ZUI0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
TPRG1 | SNV | Missense_Mutation | c.71N>T | p.Ser24Phe | p.S24F | Q6ZUI0 | protein_coding | deleterious(0.03) | benign(0.259) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
TPRG1 | SNV | Missense_Mutation | novel | c.308N>C | p.Asp103Ala | p.D103A | Q6ZUI0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TPRG1 | SNV | Missense_Mutation | novel | c.100G>C | p.Glu34Gln | p.E34Q | Q6ZUI0 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TPRG1 | SNV | Missense_Mutation | rs769151447 | c.820G>T | p.Gly274Cys | p.G274C | Q6ZUI0 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TPRG1 | SNV | Missense_Mutation | novel | c.116N>A | p.Arg39Lys | p.R39K | Q6ZUI0 | protein_coding | tolerated(1) | benign(0) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TPRG1 | SNV | Missense_Mutation | rs200541402 | c.809N>A | p.Arg270His | p.R270H | Q6ZUI0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TPRG1 | SNV | Missense_Mutation | novel | c.33N>T | p.Gln11His | p.Q11H | Q6ZUI0 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.671) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TPRG1 | SNV | Missense_Mutation | novel | c.528N>T | p.Gln176His | p.Q176H | Q6ZUI0 | protein_coding | tolerated(0.06) | benign(0.436) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TPRG1 | SNV | Missense_Mutation | novel | c.254N>C | p.Val85Ala | p.V85A | Q6ZUI0 | protein_coding | deleterious(0.05) | benign(0.057) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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