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Gene: TPO |
Gene summary for TPO |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TPO | Gene ID | 7173 |
| Gene name | thyroid peroxidase | |
| Gene Alias | MSA | |
| Cytomap | 2p25.3 | |
| Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P07202 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7173 | TPO | Adj_PTCwithHT_6 | Human | Thyroid | HT | 2.93e-61 | -1.54e+00 | 0.02 |
| 7173 | TPO | Adj_PTCwithHT_8 | Human | Thyroid | HT | 8.95e-08 | -5.95e-01 | 0.0267 |
| 7173 | TPO | PTCwithHT_1 | Human | Thyroid | HT | 5.57e-25 | -1.57e+00 | 0.0238 |
| 7173 | TPO | PTCwithHT_6 | Human | Thyroid | HT | 1.34e-57 | -1.47e+00 | 0.02 |
| 7173 | TPO | PTCwithHT_8 | Human | Thyroid | HT | 6.02e-59 | -1.51e+00 | 0.0351 |
| 7173 | TPO | PTCwithoutHT_2 | Human | Thyroid | PTC | 8.90e-62 | -1.52e+00 | 0.0419 |
| 7173 | TPO | PTCwithoutHT_7 | Human | Thyroid | PTC | 1.57e-20 | -1.45e+00 | 0.0381 |
| 7173 | TPO | male-WTA | Human | Thyroid | PTC | 3.68e-25 | -8.76e-01 | 0.1037 |
| 7173 | TPO | female-WTA | Human | Thyroid | PTC | 1.38e-04 | -7.84e-01 | 0.0726 |
| 7173 | TPO | PTC01 | Human | Thyroid | PTC | 2.83e-66 | -1.37e+00 | 0.1899 |
| 7173 | TPO | PTC04 | Human | Thyroid | PTC | 2.36e-33 | -4.69e-01 | 0.1927 |
| 7173 | TPO | PTC05 | Human | Thyroid | PTC | 6.70e-18 | -1.31e+00 | 0.2065 |
| 7173 | TPO | PTC06 | Human | Thyroid | PTC | 9.87e-11 | -6.68e-01 | 0.2057 |
| 7173 | TPO | PTC07 | Human | Thyroid | PTC | 6.58e-10 | -3.86e-01 | 0.2044 |
| 7173 | TPO | ATC08 | Human | Thyroid | ATC | 2.88e-23 | -1.55e+00 | 0.0541 |
| 7173 | TPO | ATC09 | Human | Thyroid | ATC | 4.93e-26 | -1.57e+00 | 0.2871 |
| 7173 | TPO | ATC11 | Human | Thyroid | ATC | 1.02e-07 | -1.57e+00 | 0.3386 |
| 7173 | TPO | ATC12 | Human | Thyroid | ATC | 4.01e-71 | -1.57e+00 | 0.34 |
| 7173 | TPO | ATC13 | Human | Thyroid | ATC | 1.59e-68 | -1.57e+00 | 0.34 |
| 7173 | TPO | ATC1 | Human | Thyroid | ATC | 2.78e-22 | -1.57e+00 | 0.2878 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000697930 | Thyroid | HT | response to oxidative stress | 81/1272 | 446/18723 | 2.53e-16 | 1.17e-13 | 81 |
| GO:000963627 | Thyroid | HT | response to toxic substance | 50/1272 | 262/18723 | 2.25e-11 | 3.75e-09 | 50 |
| GO:199074827 | Thyroid | HT | cellular detoxification | 31/1272 | 116/18723 | 2.29e-11 | 3.75e-09 | 31 |
| GO:009875420 | Thyroid | HT | detoxification | 36/1272 | 152/18723 | 2.63e-11 | 4.07e-09 | 36 |
| GO:009723727 | Thyroid | HT | cellular response to toxic substance | 32/1272 | 124/18723 | 3.00e-11 | 4.51e-09 | 32 |
| GO:009886926 | Thyroid | HT | cellular oxidant detoxification | 26/1272 | 101/18723 | 2.23e-09 | 2.26e-07 | 26 |
| GO:004274315 | Thyroid | HT | hydrogen peroxide metabolic process | 17/1272 | 58/18723 | 1.73e-07 | 9.32e-06 | 17 |
| GO:007259320 | Thyroid | HT | reactive oxygen species metabolic process | 39/1272 | 239/18723 | 2.90e-07 | 1.38e-05 | 39 |
| GO:00427447 | Thyroid | HT | hydrogen peroxide catabolic process | 11/1272 | 32/18723 | 4.65e-06 | 1.48e-04 | 11 |
| GO:00065759 | Thyroid | HT | cellular modified amino acid metabolic process | 28/1272 | 188/18723 | 7.21e-05 | 1.31e-03 | 28 |
| GO:0006590 | Thyroid | HT | thyroid hormone generation | 7/1272 | 20/18723 | 2.32e-04 | 3.29e-03 | 7 |
| GO:0042403 | Thyroid | HT | thyroid hormone metabolic process | 8/1272 | 27/18723 | 3.07e-04 | 4.08e-03 | 8 |
| GO:0006979113 | Thyroid | PTC | response to oxidative stress | 234/5968 | 446/18723 | 6.97e-20 | 9.77e-18 | 234 |
| GO:0072593110 | Thyroid | PTC | reactive oxygen species metabolic process | 108/5968 | 239/18723 | 1.02e-05 | 1.13e-04 | 108 |
| GO:0009636111 | Thyroid | PTC | response to toxic substance | 115/5968 | 262/18723 | 2.70e-05 | 2.63e-04 | 115 |
| GO:000657513 | Thyroid | PTC | cellular modified amino acid metabolic process | 85/5968 | 188/18723 | 8.29e-05 | 7.01e-04 | 85 |
| GO:1990748112 | Thyroid | PTC | cellular detoxification | 56/5968 | 116/18723 | 1.63e-04 | 1.26e-03 | 56 |
| GO:0097237112 | Thyroid | PTC | cellular response to toxic substance | 59/5968 | 124/18723 | 1.83e-04 | 1.39e-03 | 59 |
| GO:0098869111 | Thyroid | PTC | cellular oxidant detoxification | 49/5968 | 101/18723 | 3.52e-04 | 2.41e-03 | 49 |
| GO:00065901 | Thyroid | PTC | thyroid hormone generation | 14/5968 | 20/18723 | 5.24e-04 | 3.37e-03 | 14 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TPO | SNV | Missense_Mutation | c.2798T>A | p.Leu933His | p.L933H | P07202 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.926) | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
| TPO | SNV | Missense_Mutation | c.1990N>G | p.Leu664Val | p.L664V | P07202 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| TPO | SNV | Missense_Mutation | c.2278N>A | p.Gly760Arg | p.G760R | P07202 | protein_coding | deleterious(0.04) | probably_damaging(0.989) | TCGA-AO-A12D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| TPO | SNV | Missense_Mutation | rs199694732 | c.157N>A | p.Ala53Thr | p.A53T | P07202 | protein_coding | deleterious(0.03) | benign(0.427) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR |
| TPO | SNV | Missense_Mutation | rs761593853 | c.2723N>A | p.Arg908Gln | p.R908Q | P07202 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| TPO | SNV | Missense_Mutation | c.2432N>G | p.Ser811Cys | p.S811C | P07202 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TPO | SNV | Missense_Mutation | c.2415N>A | p.His805Gln | p.H805Q | P07202 | protein_coding | tolerated(0.35) | benign(0.106) | TCGA-E2-A14Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
| TPO | SNV | Missense_Mutation | c.23N>G | p.Ser8Cys | p.S8C | P07202 | protein_coding | deleterious(0.02) | benign(0.125) | TCGA-E2-A1IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
| TPO | SNV | Missense_Mutation | rs369563732 | c.2587N>A | p.Ala863Thr | p.A863T | P07202 | protein_coding | deleterious(0.02) | benign(0.123) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
| TPO | insertion | Frame_Shift_Ins | novel | c.2714_2715insCAGGGCCTGTGGTCCTCTTCAGGCAGGCGGGGCGGGGA | p.Pro906ArgfsTer81 | p.P906Rfs*81 | P07202 | protein_coding | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | Methimazole | METHIMAZOLE | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | Propylthiouracil | PROPYLTHIOURACIL | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | inhibitor | 178103263 | PROPYLTHIOURACIL | |
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | PROPYLTHIOURACIL | PROPYLTHIOURACIL | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | RETINOIC ACID | 8396187 | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | Carbimazole | CARBIMAZOLE | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | PROPYLTHIOURACIL | PROPYLTHIOURACIL | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | METHIMAZOLE | METHIMAZOLE | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | CARBIMAZOLE | CARBIMAZOLE | ||
| 7173 | TPO | ENZYME, DRUGGABLE GENOME, CELL SURFACE | CARBIMAZOLE | CARBIMAZOLE |
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