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Gene: TONSL |
Gene summary for TONSL |
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Gene information | Species | Human | Gene symbol | TONSL | Gene ID | 4796 |
Gene name | tonsoku like, DNA repair protein | |
Gene Alias | IKBR | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q96HA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4796 | TONSL | HCC1_Meng | Human | Liver | HCC | 2.29e-43 | 4.42e-02 | 0.0246 |
4796 | TONSL | HCC2_Meng | Human | Liver | HCC | 1.14e-08 | 4.81e-02 | 0.0107 |
4796 | TONSL | HCC1 | Human | Liver | HCC | 4.48e-02 | 9.26e-01 | 0.5336 |
4796 | TONSL | HCC2 | Human | Liver | HCC | 1.07e-11 | 1.59e+00 | 0.5341 |
4796 | TONSL | HCC5 | Human | Liver | HCC | 2.01e-06 | 7.85e-01 | 0.4932 |
4796 | TONSL | S014 | Human | Liver | HCC | 4.93e-08 | 5.24e-01 | 0.2254 |
4796 | TONSL | S015 | Human | Liver | HCC | 1.93e-05 | 4.79e-01 | 0.2375 |
4796 | TONSL | S016 | Human | Liver | HCC | 3.47e-05 | 3.72e-01 | 0.2243 |
4796 | TONSL | S027 | Human | Liver | HCC | 1.68e-05 | 5.95e-01 | 0.2446 |
4796 | TONSL | S028 | Human | Liver | HCC | 2.69e-14 | 9.26e-01 | 0.2503 |
4796 | TONSL | S029 | Human | Liver | HCC | 1.32e-19 | 7.94e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:0006261 | Liver | HCC | DNA-dependent DNA replication | 80/7958 | 151/18723 | 5.91e-03 | 2.44e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TONSL | SNV | Missense_Mutation | novel | c.1689N>C | p.Trp563Cys | p.W563C | Q96HA7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
TONSL | SNV | Missense_Mutation | novel | c.313N>C | p.Glu105Gln | p.E105Q | Q96HA7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TONSL | SNV | Missense_Mutation | c.1435N>A | p.Glu479Lys | p.E479K | Q96HA7 | protein_coding | tolerated(0.64) | benign(0.006) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TONSL | insertion | Nonsense_Mutation | novel | c.3591_3592insATCTTCATTCCCTAGGACCCCCTCTTTC | p.Tyr1198IlefsTer5 | p.Y1198Ifs*5 | Q96HA7 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TONSL | insertion | Frame_Shift_Ins | novel | c.310_311insGGCTGCAGCCCAGCACCCC | p.Thr104ArgfsTer25 | p.T104Rfs*25 | Q96HA7 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TONSL | SNV | Missense_Mutation | c.3334N>A | p.Pro1112Thr | p.P1112T | Q96HA7 | protein_coding | tolerated(0.52) | benign(0.193) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TONSL | SNV | Missense_Mutation | c.3674C>T | p.Ser1225Phe | p.S1225F | Q96HA7 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
TONSL | SNV | Missense_Mutation | rs782170769 | c.3347N>A | p.Arg1116His | p.R1116H | Q96HA7 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TONSL | SNV | Missense_Mutation | rs776417303 | c.2288N>T | p.Ser763Leu | p.S763L | Q96HA7 | protein_coding | tolerated(0.36) | benign(0) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TONSL | SNV | Missense_Mutation | rs529030862 | c.2666C>T | p.Ala889Val | p.A889V | Q96HA7 | protein_coding | tolerated(0.41) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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