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Gene: TOMM70 |
Gene summary for TOMM70 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TOMM70 | Gene ID | 9868 |
Gene name | translocase of outer mitochondrial membrane 70 | |
Gene Alias | TOMM70A | |
Cytomap | 3q12.2 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | O94826 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9868 | TOMM70 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.42e-04 | 3.28e-01 | -0.1954 |
9868 | TOMM70 | A015-C-203 | Human | Colorectum | FAP | 6.97e-15 | -2.24e-01 | -0.1294 |
9868 | TOMM70 | A015-C-204 | Human | Colorectum | FAP | 7.08e-03 | -2.19e-01 | -0.0228 |
9868 | TOMM70 | A002-C-201 | Human | Colorectum | FAP | 4.30e-06 | -2.20e-01 | 0.0324 |
9868 | TOMM70 | A002-C-203 | Human | Colorectum | FAP | 4.21e-03 | -1.67e-01 | 0.2786 |
9868 | TOMM70 | A001-C-108 | Human | Colorectum | FAP | 1.18e-06 | -1.80e-01 | -0.0272 |
9868 | TOMM70 | A002-C-205 | Human | Colorectum | FAP | 2.87e-07 | -2.23e-01 | -0.1236 |
9868 | TOMM70 | A001-C-104 | Human | Colorectum | FAP | 5.51e-04 | -1.45e-01 | 0.0184 |
9868 | TOMM70 | A015-C-006 | Human | Colorectum | FAP | 4.79e-04 | -2.57e-01 | -0.0994 |
9868 | TOMM70 | A015-C-106 | Human | Colorectum | FAP | 1.20e-04 | -1.57e-01 | -0.0511 |
9868 | TOMM70 | A002-C-114 | Human | Colorectum | FAP | 4.84e-06 | -2.28e-01 | -0.1561 |
9868 | TOMM70 | A015-C-104 | Human | Colorectum | FAP | 7.55e-13 | -2.32e-01 | -0.1899 |
9868 | TOMM70 | A001-C-014 | Human | Colorectum | FAP | 3.49e-09 | -2.08e-01 | 0.0135 |
9868 | TOMM70 | A002-C-016 | Human | Colorectum | FAP | 9.65e-11 | -2.04e-01 | 0.0521 |
9868 | TOMM70 | A015-C-002 | Human | Colorectum | FAP | 7.92e-04 | -2.16e-01 | -0.0763 |
9868 | TOMM70 | A001-C-203 | Human | Colorectum | FAP | 3.08e-05 | -1.48e-01 | -0.0481 |
9868 | TOMM70 | A002-C-116 | Human | Colorectum | FAP | 1.33e-11 | -1.77e-01 | -0.0452 |
9868 | TOMM70 | A014-C-008 | Human | Colorectum | FAP | 9.40e-03 | -2.08e-01 | -0.191 |
9868 | TOMM70 | A018-E-020 | Human | Colorectum | FAP | 4.01e-07 | -2.73e-01 | -0.2034 |
9868 | TOMM70 | F034 | Human | Colorectum | FAP | 3.17e-05 | -8.13e-02 | -0.0665 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0070585 | Colorectum | AD | protein localization to mitochondrion | 51/3918 | 125/18723 | 3.40e-07 | 1.33e-05 | 51 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0072655 | Colorectum | AD | establishment of protein localization to mitochondrion | 47/3918 | 120/18723 | 3.76e-06 | 1.04e-04 | 47 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0006626 | Colorectum | AD | protein targeting to mitochondrion | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0007007 | Colorectum | AD | inner mitochondrial membrane organization | 18/3918 | 38/18723 | 2.45e-04 | 3.09e-03 | 18 |
GO:0090151 | Colorectum | AD | establishment of protein localization to mitochondrial membrane | 15/3918 | 30/18723 | 3.85e-04 | 4.39e-03 | 15 |
GO:0051205 | Colorectum | AD | protein insertion into membrane | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0032481 | Colorectum | AD | positive regulation of type I interferon production | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:0051204 | Colorectum | AD | protein insertion into mitochondrial membrane | 12/3918 | 25/18723 | 2.30e-03 | 1.80e-02 | 12 |
GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00725944 | Colorectum | FAP | establishment of protein localization to organelle | 96/2622 | 422/18723 | 6.63e-07 | 3.20e-05 | 96 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:19905423 | Colorectum | FAP | mitochondrial transmembrane transport | 29/2622 | 102/18723 | 1.09e-04 | 1.80e-03 | 29 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOMM70 | SNV | Missense_Mutation | novel | c.1340G>A | p.Arg447His | p.R447H | O94826 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOMM70 | SNV | Missense_Mutation | novel | c.1793C>G | p.Ala598Gly | p.A598G | O94826 | protein_coding | tolerated(0.07) | possibly_damaging(0.468) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
TOMM70 | SNV | Missense_Mutation | novel | c.136G>C | p.Gly46Arg | p.G46R | O94826 | protein_coding | deleterious(0) | benign(0.284) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
TOMM70 | SNV | Missense_Mutation | novel | c.1213N>T | p.His405Tyr | p.H405Y | O94826 | protein_coding | deleterious(0) | possibly_damaging(0.457) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TOMM70 | SNV | Missense_Mutation | rs144929730 | c.1199N>G | p.Asn400Ser | p.N400S | O94826 | protein_coding | tolerated(0.09) | probably_damaging(0.932) | TCGA-AA-3675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TOMM70 | SNV | Missense_Mutation | c.1579C>A | p.Leu527Met | p.L527M | O94826 | protein_coding | deleterious(0.03) | possibly_damaging(0.828) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TOMM70 | SNV | Missense_Mutation | rs9833995 | c.577N>T | p.Arg193Cys | p.R193C | O94826 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
TOMM70 | SNV | Missense_Mutation | c.1028N>A | p.Gly343Asp | p.G343D | O94826 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TOMM70 | SNV | Missense_Mutation | rs756063544 | c.1771G>A | p.Ala591Thr | p.A591T | O94826 | protein_coding | deleterious(0) | possibly_damaging(0.757) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOMM70 | SNV | Missense_Mutation | c.1810N>G | p.Lys604Glu | p.K604E | O94826 | protein_coding | tolerated(0.27) | probably_damaging(0.971) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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