Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TOMM70

Gene summary for TOMM70

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TOMM70

Gene ID

9868

Gene nametranslocase of outer mitochondrial membrane 70
Gene AliasTOMM70A
Cytomap3q12.2
Gene Typeprotein-coding
GO ID

GO:0001816

UniProtAcc

O94826


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9868TOMM70HTA11_347_2000001011HumanColorectumAD9.42e-043.28e-01-0.1954
9868TOMM70A015-C-203HumanColorectumFAP6.97e-15-2.24e-01-0.1294
9868TOMM70A015-C-204HumanColorectumFAP7.08e-03-2.19e-01-0.0228
9868TOMM70A002-C-201HumanColorectumFAP4.30e-06-2.20e-010.0324
9868TOMM70A002-C-203HumanColorectumFAP4.21e-03-1.67e-010.2786
9868TOMM70A001-C-108HumanColorectumFAP1.18e-06-1.80e-01-0.0272
9868TOMM70A002-C-205HumanColorectumFAP2.87e-07-2.23e-01-0.1236
9868TOMM70A001-C-104HumanColorectumFAP5.51e-04-1.45e-010.0184
9868TOMM70A015-C-006HumanColorectumFAP4.79e-04-2.57e-01-0.0994
9868TOMM70A015-C-106HumanColorectumFAP1.20e-04-1.57e-01-0.0511
9868TOMM70A002-C-114HumanColorectumFAP4.84e-06-2.28e-01-0.1561
9868TOMM70A015-C-104HumanColorectumFAP7.55e-13-2.32e-01-0.1899
9868TOMM70A001-C-014HumanColorectumFAP3.49e-09-2.08e-010.0135
9868TOMM70A002-C-016HumanColorectumFAP9.65e-11-2.04e-010.0521
9868TOMM70A015-C-002HumanColorectumFAP7.92e-04-2.16e-01-0.0763
9868TOMM70A001-C-203HumanColorectumFAP3.08e-05-1.48e-01-0.0481
9868TOMM70A002-C-116HumanColorectumFAP1.33e-11-1.77e-01-0.0452
9868TOMM70A014-C-008HumanColorectumFAP9.40e-03-2.08e-01-0.191
9868TOMM70A018-E-020HumanColorectumFAP4.01e-07-2.73e-01-0.2034
9868TOMM70F034HumanColorectumFAP3.17e-05-8.13e-02-0.0665
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006839ColorectumADmitochondrial transport102/3918254/187231.87e-123.08e-10102
GO:0072594ColorectumADestablishment of protein localization to organelle148/3918422/187237.95e-121.04e-09148
GO:0090150ColorectumADestablishment of protein localization to membrane100/3918260/187236.01e-116.33e-09100
GO:1990542ColorectumADmitochondrial transmembrane transport47/3918102/187231.09e-086.52e-0747
GO:0006605ColorectumADprotein targeting105/3918314/187231.39e-076.44e-06105
GO:0070585ColorectumADprotein localization to mitochondrion51/3918125/187233.40e-071.33e-0551
GO:0007006ColorectumADmitochondrial membrane organization48/3918116/187234.53e-071.72e-0548
GO:0072655ColorectumADestablishment of protein localization to mitochondrion47/3918120/187233.76e-061.04e-0447
GO:0017038ColorectumADprotein import67/3918206/187236.34e-051.05e-0367
GO:0006626ColorectumADprotein targeting to mitochondrion37/3918100/187231.58e-042.20e-0337
GO:0007007ColorectumADinner mitochondrial membrane organization18/391838/187232.45e-043.09e-0318
GO:0090151ColorectumADestablishment of protein localization to mitochondrial membrane15/391830/187233.85e-044.39e-0315
GO:0051205ColorectumADprotein insertion into membrane23/391857/187236.62e-046.80e-0323
GO:0032481ColorectumADpositive regulation of type I interferon production23/391858/187238.82e-048.53e-0323
GO:0051204ColorectumADprotein insertion into mitochondrial membrane12/391825/187232.30e-031.80e-0212
GO:0071806ColorectumADprotein transmembrane transport21/391859/187236.58e-034.08e-0221
GO:00901504ColorectumFAPestablishment of protein localization to membrane69/2622260/187236.40e-084.54e-0669
GO:00725944ColorectumFAPestablishment of protein localization to organelle96/2622422/187236.63e-073.20e-0596
GO:00066054ColorectumFAPprotein targeting74/2622314/187233.21e-061.17e-0474
GO:19905423ColorectumFAPmitochondrial transmembrane transport29/2622102/187231.09e-041.80e-0329
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TOMM70SNVMissense_Mutationnovelc.1340G>Ap.Arg447Hisp.R447HO94826protein_codingdeleterious(0)probably_damaging(0.994)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TOMM70SNVMissense_Mutationnovelc.1793C>Gp.Ala598Glyp.A598GO94826protein_codingtolerated(0.07)possibly_damaging(0.468)TCGA-VS-A8QC-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapypaclitaxelPD
TOMM70SNVMissense_Mutationnovelc.136G>Cp.Gly46Argp.G46RO94826protein_codingdeleterious(0)benign(0.284)TCGA-VS-A953-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
TOMM70SNVMissense_Mutationnovelc.1213N>Tp.His405Tyrp.H405YO94826protein_codingdeleterious(0)possibly_damaging(0.457)TCGA-ZJ-A8QR-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TOMM70SNVMissense_Mutationrs144929730c.1199N>Gp.Asn400Serp.N400SO94826protein_codingtolerated(0.09)probably_damaging(0.932)TCGA-AA-3675-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
TOMM70SNVMissense_Mutationc.1579C>Ap.Leu527Metp.L527MO94826protein_codingdeleterious(0.03)possibly_damaging(0.828)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
TOMM70SNVMissense_Mutationrs9833995c.577N>Tp.Arg193Cysp.R193CO94826protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-A01R-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapy5-fluorouracilPD
TOMM70SNVMissense_Mutationc.1028N>Ap.Gly343Aspp.G343DO94826protein_codingdeleterious(0)probably_damaging(0.996)TCGA-AA-A02R-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
TOMM70SNVMissense_Mutationrs756063544c.1771G>Ap.Ala591Thrp.A591TO94826protein_codingdeleterious(0)possibly_damaging(0.757)TCGA-AZ-4313-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
TOMM70SNVMissense_Mutationc.1810N>Gp.Lys604Glup.K604EO94826protein_codingtolerated(0.27)probably_damaging(0.971)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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