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Gene: TOLLIP |
Gene summary for TOLLIP |
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Gene information | Species | Human | Gene symbol | TOLLIP | Gene ID | 54472 |
Gene name | toll interacting protein | |
Gene Alias | IL-1RAcPIP | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | B3KR28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54472 | TOLLIP | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.84e-02 | 1.91e-01 | 0.0155 |
54472 | TOLLIP | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.31e-09 | 5.08e-01 | -0.1808 |
54472 | TOLLIP | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.25e-03 | 3.77e-01 | -0.0811 |
54472 | TOLLIP | HTA11_347_2000001011 | Human | Colorectum | AD | 1.16e-13 | 4.01e-01 | -0.1954 |
54472 | TOLLIP | HTA11_411_2000001011 | Human | Colorectum | SER | 1.38e-02 | 6.16e-01 | -0.2602 |
54472 | TOLLIP | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.80e-03 | 4.06e-01 | -0.2196 |
54472 | TOLLIP | HTA11_83_2000001011 | Human | Colorectum | SER | 3.87e-04 | 3.91e-01 | -0.1526 |
54472 | TOLLIP | HTA11_696_2000001011 | Human | Colorectum | AD | 1.07e-07 | 2.94e-01 | -0.1464 |
54472 | TOLLIP | HTA11_866_2000001011 | Human | Colorectum | AD | 8.33e-04 | 1.81e-01 | -0.1001 |
54472 | TOLLIP | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.91e-09 | 3.57e-01 | -0.059 |
54472 | TOLLIP | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.06e-05 | 4.11e-01 | -0.1706 |
54472 | TOLLIP | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.91e-03 | 2.68e-01 | -0.2061 |
54472 | TOLLIP | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.49e-08 | 2.38e-01 | 0.0674 |
54472 | TOLLIP | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.95e-09 | 2.66e-01 | 0.294 |
54472 | TOLLIP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.03e-26 | 6.40e-01 | 0.3859 |
54472 | TOLLIP | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.57e-06 | 2.26e-01 | 0.3005 |
54472 | TOLLIP | LZE4T | Human | Esophagus | ESCC | 2.47e-13 | 9.21e-02 | 0.0811 |
54472 | TOLLIP | LZE5T | Human | Esophagus | ESCC | 7.76e-03 | 1.02e-01 | 0.0514 |
54472 | TOLLIP | LZE7T | Human | Esophagus | ESCC | 2.51e-09 | 1.05e-01 | 0.0667 |
54472 | TOLLIP | LZE8T | Human | Esophagus | ESCC | 5.99e-11 | 1.48e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0036010 | Colorectum | AD | protein localization to endosome | 12/3918 | 24/18723 | 1.48e-03 | 1.25e-02 | 12 |
GO:19033201 | Colorectum | SER | regulation of protein modification by small protein conjugation or removal | 70/2897 | 242/18723 | 6.84e-08 | 4.42e-06 | 70 |
GO:1903322 | Colorectum | SER | positive regulation of protein modification by small protein conjugation or removal | 34/2897 | 138/18723 | 3.30e-03 | 2.83e-02 | 34 |
GO:00360101 | Colorectum | SER | protein localization to endosome | 9/2897 | 24/18723 | 7.19e-03 | 4.99e-02 | 9 |
GO:19033202 | Colorectum | MSS | regulation of protein modification by small protein conjugation or removal | 82/3467 | 242/18723 | 7.49e-09 | 4.63e-07 | 82 |
GO:00360102 | Colorectum | MSS | protein localization to endosome | 12/3467 | 24/18723 | 4.68e-04 | 5.50e-03 | 12 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:001692512 | Esophagus | ESCC | protein sumoylation | 41/8552 | 53/18723 | 2.49e-06 | 2.86e-05 | 41 |
GO:00360106 | Esophagus | ESCC | protein localization to endosome | 18/8552 | 24/18723 | 3.43e-03 | 1.41e-02 | 18 |
GO:00332331 | Esophagus | ESCC | regulation of protein sumoylation | 18/8552 | 25/18723 | 7.04e-03 | 2.56e-02 | 18 |
GO:0033235 | Esophagus | ESCC | positive regulation of protein sumoylation | 10/8552 | 12/18723 | 8.94e-03 | 3.12e-02 | 10 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:00182051 | Liver | Cirrhotic | peptidyl-lysine modification | 134/4634 | 376/18723 | 1.29e-06 | 2.59e-05 | 134 |
GO:19033222 | Liver | Cirrhotic | positive regulation of protein modification by small protein conjugation or removal | 52/4634 | 138/18723 | 4.91e-04 | 3.94e-03 | 52 |
GO:00705553 | Liver | Cirrhotic | response to interleukin-1 | 52/4634 | 143/18723 | 1.27e-03 | 8.54e-03 | 52 |
GO:0071347 | Liver | Cirrhotic | cellular response to interleukin-1 | 41/4634 | 113/18723 | 4.08e-03 | 2.19e-02 | 41 |
GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04620 | Oral cavity | OSCC | Toll-like receptor signaling pathway | 58/3704 | 104/8465 | 8.77e-03 | 1.98e-02 | 1.01e-02 | 58 |
hsa046201 | Oral cavity | OSCC | Toll-like receptor signaling pathway | 58/3704 | 104/8465 | 8.77e-03 | 1.98e-02 | 1.01e-02 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOLLIP | SNV | Missense_Mutation | novel | c.230N>A | p.Cys77Tyr | p.C77Y | Q9H0E2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TOLLIP | SNV | Missense_Mutation | c.325N>T | p.Pro109Ser | p.P109S | Q9H0E2 | protein_coding | tolerated(0.05) | probably_damaging(0.981) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOLLIP | SNV | Missense_Mutation | rs773801820 | c.74N>T | p.Thr25Met | p.T25M | Q9H0E2 | protein_coding | deleterious(0.03) | benign(0.009) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
TOLLIP | SNV | Missense_Mutation | c.109N>A | p.Ala37Thr | p.A37T | Q9H0E2 | protein_coding | tolerated(0.31) | benign(0.269) | TCGA-CK-4947-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Other, specify in notes | folinic | SD | |
TOLLIP | SNV | Missense_Mutation | c.714G>T | p.Gln238His | p.Q238H | Q9H0E2 | protein_coding | tolerated(0.14) | benign(0.046) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOLLIP | SNV | Missense_Mutation | novel | c.84N>T | p.Gln28His | p.Q28H | Q9H0E2 | protein_coding | tolerated(0.09) | benign(0.342) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TOLLIP | SNV | Missense_Mutation | novel | c.57N>T | p.Gln19His | p.Q19H | Q9H0E2 | protein_coding | tolerated(0.16) | benign(0.007) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TOLLIP | SNV | Missense_Mutation | novel | c.331N>T | p.Gly111Cys | p.G111C | Q9H0E2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TOLLIP | SNV | Missense_Mutation | rs552271777 | c.619G>A | p.Ala207Thr | p.A207T | Q9H0E2 | protein_coding | tolerated(0.28) | benign(0.001) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TOLLIP | SNV | Missense_Mutation | rs368124186 | c.748N>T | p.Arg250Cys | p.R250C | Q9H0E2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54472 | TOLLIP | KINASE | acetylcysteine | ACETYLCYSTEINE |
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