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Gene: TNS4 |
Gene summary for TNS4 |
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Gene information | Species | Human | Gene symbol | TNS4 | Gene ID | 84951 |
Gene name | tensin 4 | |
Gene Alias | CTEN | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q6PJP3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84951 | TNS4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.85e-05 | 2.17e-01 | 0.0155 |
84951 | TNS4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.45e-19 | 6.71e-01 | -0.0811 |
84951 | TNS4 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.50e-03 | 2.78e-01 | -0.1088 |
84951 | TNS4 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.12e-03 | 1.84e-01 | -0.1526 |
84951 | TNS4 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.85e-03 | 1.93e-01 | -0.1464 |
84951 | TNS4 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.45e-03 | 1.72e-01 | -0.1001 |
84951 | TNS4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.94e-16 | 6.23e-01 | -0.059 |
84951 | TNS4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.84e-06 | 3.92e-01 | 0.0338 |
84951 | TNS4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.83e-10 | 3.53e-01 | 0.0674 |
84951 | TNS4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.47e-17 | 8.19e-01 | 0.0588 |
84951 | TNS4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.15e-50 | 1.14e+00 | 0.294 |
84951 | TNS4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.06e-26 | 8.79e-01 | 0.3859 |
84951 | TNS4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.07e-05 | 3.53e-01 | 0.2585 |
84951 | TNS4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.60e-22 | 6.86e-01 | 0.3005 |
84951 | TNS4 | A001-C-207 | Human | Colorectum | FAP | 2.04e-07 | 4.68e-01 | 0.1278 |
84951 | TNS4 | A002-C-203 | Human | Colorectum | FAP | 9.11e-04 | 2.47e-01 | 0.2786 |
84951 | TNS4 | A001-C-108 | Human | Colorectum | FAP | 6.95e-10 | 4.66e-01 | -0.0272 |
84951 | TNS4 | A001-C-104 | Human | Colorectum | FAP | 1.03e-16 | 5.26e-01 | 0.0184 |
84951 | TNS4 | A001-C-014 | Human | Colorectum | FAP | 7.04e-05 | 3.76e-01 | 0.0135 |
84951 | TNS4 | A001-C-203 | Human | Colorectum | FAP | 7.45e-03 | 2.85e-01 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNS4 | SNV | Missense_Mutation | c.658N>T | p.Gly220Cys | p.G220C | Q8IZW8 | protein_coding | tolerated(0.08) | benign(0.174) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
TNS4 | SNV | Missense_Mutation | novel | c.1228C>T | p.Pro410Ser | p.P410S | Q8IZW8 | protein_coding | tolerated(0.57) | benign(0.01) | TCGA-AR-A5QM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | PD |
TNS4 | SNV | Missense_Mutation | c.563N>A | p.Arg188Lys | p.R188K | Q8IZW8 | protein_coding | tolerated(0.51) | possibly_damaging(0.675) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TNS4 | SNV | Missense_Mutation | novel | c.1220N>C | p.Asn407Thr | p.N407T | Q8IZW8 | protein_coding | tolerated(0.15) | benign(0.026) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TNS4 | SNV | Missense_Mutation | novel | c.970N>G | p.Ser324Ala | p.S324A | Q8IZW8 | protein_coding | tolerated(0.28) | benign(0.182) | TCGA-EW-A2FR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | SD |
TNS4 | SNV | Missense_Mutation | rs150836111 | c.1169N>A | p.Arg390Gln | p.R390Q | Q8IZW8 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNS4 | SNV | Missense_Mutation | c.503N>G | p.Ser168Cys | p.S168C | Q8IZW8 | protein_coding | tolerated(0.1) | benign(0.011) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TNS4 | SNV | Missense_Mutation | novel | c.245N>T | p.Ser82Phe | p.S82F | Q8IZW8 | protein_coding | deleterious(0.03) | benign(0.28) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNS4 | SNV | Missense_Mutation | c.1156N>C | p.Ser386Pro | p.S386P | Q8IZW8 | protein_coding | tolerated(0.96) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TNS4 | SNV | Missense_Mutation | c.26N>C | p.Leu9Pro | p.L9P | Q8IZW8 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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