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Gene: TNNT3 |
Gene summary for TNNT3 |
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Gene information | Species | Human | Gene symbol | TNNT3 | Gene ID | 7140 |
Gene name | troponin T3, fast skeletal type | |
Gene Alias | DA2B2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P45378 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7140 | TNNT3 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 4.89e-01 | 0.067 |
7140 | TNNT3 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.67e-01 | 0.0889 |
7140 | TNNT3 | P10T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.37e-01 | 0.116 |
7140 | TNNT3 | P20T-E | Human | Esophagus | ESCC | 1.51e-02 | 9.49e-02 | 0.1124 |
7140 | TNNT3 | P54T-E | Human | Esophagus | ESCC | 9.92e-04 | 1.91e-01 | 0.0975 |
7140 | TNNT3 | P62T-E | Human | Esophagus | ESCC | 8.76e-11 | 3.82e-01 | 0.1302 |
7140 | TNNT3 | P79T-E | Human | Esophagus | ESCC | 2.39e-24 | 9.22e-01 | 0.1154 |
7140 | TNNT3 | P80T-E | Human | Esophagus | ESCC | 3.35e-21 | 7.79e-01 | 0.155 |
7140 | TNNT3 | P89T-E | Human | Esophagus | ESCC | 4.36e-04 | 5.44e-01 | 0.1752 |
7140 | TNNT3 | P128T-E | Human | Esophagus | ESCC | 1.91e-31 | 1.18e+00 | 0.1241 |
7140 | TNNT3 | P130T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.71e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:00434627 | Esophagus | ESCC | regulation of ATPase activity | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNNT3 | SNV | Missense_Mutation | novel | c.271N>T | p.Ala91Ser | p.A91S | P45378 | protein_coding | tolerated(0.42) | benign(0.181) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | rs121434638 | c.188N>A | p.Arg63His | p.R63H | P45378 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0DG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TNNT3 | insertion | In_Frame_Ins | rs764019640 | c.262_264dupGAG | p.Glu88dup | p.E88dup | P45378 | protein_coding | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | ||
TNNT3 | insertion | In_Frame_Ins | rs764019640 | c.250_251insAGG | p.Glu88dup | p.E88dup | P45378 | protein_coding | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
TNNT3 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | P45378 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A6-2675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNNT3 | SNV | Missense_Mutation | novel | c.745N>T | p.Ala249Ser | p.A249S | P45378 | protein_coding | tolerated(0.21) | benign(0.025) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TNNT3 | SNV | Missense_Mutation | novel | c.119G>T | p.Arg40Ile | p.R40I | P45378 | protein_coding | deleterious(0) | benign(0.133) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | c.88N>A | p.Ala30Thr | p.A30T | P45378 | protein_coding | tolerated(0.55) | benign(0) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNNT3 | SNV | Missense_Mutation | rs768888979 | c.40G>A | p.Glu14Lys | p.E14K | P45378 | protein_coding | tolerated_low_confidence(0.11) | probably_damaging(0.956) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | rs867571200 | c.253G>A | p.Glu85Lys | p.E85K | P45378 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7140 | TNNT3 | NA | activator | CHEMBL3039529 | TIRASEMTIV |
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