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Gene: TMX3 |
Gene summary for TMX3 |
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Gene information | Species | Human | Gene symbol | TMX3 | Gene ID | 54495 |
Gene name | thioredoxin related transmembrane protein 3 | |
Gene Alias | PDIA13 | |
Cytomap | 18q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96JJ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54495 | TMX3 | LZE4T | Human | Esophagus | ESCC | 1.77e-02 | 1.42e-01 | 0.0811 |
54495 | TMX3 | LZE7T | Human | Esophagus | ESCC | 3.19e-02 | 3.61e-01 | 0.0667 |
54495 | TMX3 | LZE24T | Human | Esophagus | ESCC | 6.25e-04 | 2.11e-02 | 0.0596 |
54495 | TMX3 | P2T-E | Human | Esophagus | ESCC | 3.25e-14 | 2.10e-01 | 0.1177 |
54495 | TMX3 | P4T-E | Human | Esophagus | ESCC | 1.12e-18 | 3.65e-01 | 0.1323 |
54495 | TMX3 | P5T-E | Human | Esophagus | ESCC | 2.64e-07 | 5.29e-02 | 0.1327 |
54495 | TMX3 | P8T-E | Human | Esophagus | ESCC | 3.58e-12 | 2.39e-01 | 0.0889 |
54495 | TMX3 | P9T-E | Human | Esophagus | ESCC | 5.48e-04 | 5.59e-02 | 0.1131 |
54495 | TMX3 | P10T-E | Human | Esophagus | ESCC | 2.25e-10 | 1.65e-01 | 0.116 |
54495 | TMX3 | P11T-E | Human | Esophagus | ESCC | 5.70e-07 | 3.53e-01 | 0.1426 |
54495 | TMX3 | P12T-E | Human | Esophagus | ESCC | 5.78e-15 | 1.58e-01 | 0.1122 |
54495 | TMX3 | P15T-E | Human | Esophagus | ESCC | 8.20e-08 | 9.76e-02 | 0.1149 |
54495 | TMX3 | P16T-E | Human | Esophagus | ESCC | 5.60e-14 | 1.91e-01 | 0.1153 |
54495 | TMX3 | P19T-E | Human | Esophagus | ESCC | 1.59e-04 | 2.76e-01 | 0.1662 |
54495 | TMX3 | P20T-E | Human | Esophagus | ESCC | 3.97e-11 | 6.54e-02 | 0.1124 |
54495 | TMX3 | P21T-E | Human | Esophagus | ESCC | 4.65e-11 | 2.71e-01 | 0.1617 |
54495 | TMX3 | P22T-E | Human | Esophagus | ESCC | 2.30e-12 | 2.65e-01 | 0.1236 |
54495 | TMX3 | P23T-E | Human | Esophagus | ESCC | 2.28e-13 | 1.56e-01 | 0.108 |
54495 | TMX3 | P24T-E | Human | Esophagus | ESCC | 9.22e-07 | 1.20e-01 | 0.1287 |
54495 | TMX3 | P26T-E | Human | Esophagus | ESCC | 3.12e-11 | 1.75e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMX3 | SNV | Missense_Mutation | rs868505578 | c.1141N>T | p.Leu381Phe | p.L381F | Q96JJ7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMX3 | SNV | Missense_Mutation | rs746563370 | c.662C>T | p.Ser221Leu | p.S221L | Q96JJ7 | protein_coding | tolerated(0.05) | benign(0.015) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
TMX3 | SNV | Missense_Mutation | c.731N>T | p.Asp244Val | p.D244V | Q96JJ7 | protein_coding | deleterious(0) | possibly_damaging(0.892) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
TMX3 | deletion | Frame_Shift_Del | novel | c.256delN | p.Ser86ProfsTer20 | p.S86Pfs*20 | Q96JJ7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TMX3 | SNV | Missense_Mutation | rs201057152 | c.452N>A | p.Arg151His | p.R151H | Q96JJ7 | protein_coding | tolerated(0.12) | benign(0.339) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMX3 | SNV | Missense_Mutation | novel | c.1295C>A | p.Pro432His | p.P432H | Q96JJ7 | protein_coding | deleterious_low_confidence(0.05) | benign(0.001) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMX3 | SNV | Missense_Mutation | novel | c.355A>C | p.Lys119Gln | p.K119Q | Q96JJ7 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TMX3 | SNV | Missense_Mutation | c.979N>G | p.Lys327Glu | p.K327E | Q96JJ7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
TMX3 | SNV | Missense_Mutation | rs552445199 | c.116G>A | p.Arg39Gln | p.R39Q | Q96JJ7 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMX3 | SNV | Missense_Mutation | c.509C>T | p.Ala170Val | p.A170V | Q96JJ7 | protein_coding | tolerated(1) | benign(0.055) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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