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Gene: TMX2 |
Gene summary for TMX2 |
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Gene information | Species | Human | Gene symbol | TMX2 | Gene ID | 51075 |
Gene name | thioredoxin related transmembrane protein 2 | |
Gene Alias | CGI-31 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9Y320 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51075 | TMX2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.06e-10 | 2.08e-01 | 0.0155 |
51075 | TMX2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.90e-11 | 3.00e-01 | -0.1808 |
51075 | TMX2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-12 | 3.82e-01 | -0.0811 |
51075 | TMX2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.86e-16 | 4.42e-01 | -0.1088 |
51075 | TMX2 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.41e-38 | 6.42e-01 | -0.1954 |
51075 | TMX2 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.05e-01 | -0.2602 |
51075 | TMX2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.37e-01 | -0.2196 |
51075 | TMX2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.03e-08 | 3.09e-01 | -0.1207 |
51075 | TMX2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.71e-21 | 5.64e-01 | -0.1526 |
51075 | TMX2 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.92e-23 | 4.31e-01 | -0.1464 |
51075 | TMX2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.93e-21 | 3.77e-01 | -0.1001 |
51075 | TMX2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.12e-26 | 6.11e-01 | -0.059 |
51075 | TMX2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 4.65e-01 | -0.1706 |
51075 | TMX2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.52e-06 | 2.80e-01 | -0.2061 |
51075 | TMX2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.22e-05 | 3.63e-01 | -0.1462 |
51075 | TMX2 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.66e-12 | 4.68e-01 | -0.0842 |
51075 | TMX2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.08e-04 | 2.52e-01 | -0.0179 |
51075 | TMX2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.29e-15 | 3.30e-01 | 0.096 |
51075 | TMX2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.34e-04 | 3.36e-01 | 0.0446 |
51075 | TMX2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 4.07e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMX2 | insertion | In_Frame_Ins | novel | c.184_185insCTTTGGTTGAATTCA | p.Asp62delinsAlaLeuValGluPheAsn | p.D62delinsALVEFN | Q9Y320 | protein_coding | TCGA-BH-A0HL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
TMX2 | SNV | Missense_Mutation | novel | c.85N>G | p.Ser29Ala | p.S29A | Q9Y320 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMX2 | SNV | Missense_Mutation | c.486N>A | p.Phe162Leu | p.F162L | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TMX2 | SNV | Missense_Mutation | c.758N>A | p.Arg253Gln | p.R253Q | Q9Y320 | protein_coding | tolerated(0.18) | probably_damaging(0.974) | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | c.518N>G | p.Phe173Cys | p.F173C | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | novel | c.367N>A | p.Phe123Ile | p.F123I | Q9Y320 | protein_coding | tolerated(0.17) | benign(0.03) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMX2 | SNV | Missense_Mutation | rs778852347 | c.787N>T | p.Arg263Trp | p.R263W | Q9Y320 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMX2 | SNV | Missense_Mutation | novel | c.92N>C | p.Leu31Pro | p.L31P | Q9Y320 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
TMX2 | SNV | Missense_Mutation | c.148N>T | p.Pro50Ser | p.P50S | Q9Y320 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMX2 | SNV | Missense_Mutation | rs757544083 | c.593N>A | p.Arg198His | p.R198H | Q9Y320 | protein_coding | deleterious(0.02) | benign(0.219) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51075 | TMX2 | THIOREDOXIN, DRUGGABLE GENOME | ethanol | ALCOHOL | 32451486 |
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