Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TMSB15A

Gene summary for TMSB15A

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TMSB15A

Gene ID

11013

Gene namethymosin beta 15A
Gene AliasTMSB15
CytomapXq22.1
Gene Typeprotein-coding
GO ID

GO:0006928

UniProtAcc

P0CG34


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11013TMSB15ALZE24THumanEsophagusESCC1.42e-037.43e-010.0596
11013TMSB15AP2T-EHumanEsophagusESCC8.01e-371.06e+000.1177
11013TMSB15AP4T-EHumanEsophagusESCC2.93e-062.76e-010.1323
11013TMSB15AP10T-EHumanEsophagusESCC5.72e-245.98e-010.116
11013TMSB15AP16T-EHumanEsophagusESCC8.77e-041.55e-010.1153
11013TMSB15AP22T-EHumanEsophagusESCC3.68e-021.37e-010.1236
11013TMSB15AP76T-EHumanEsophagusESCC9.47e-083.78e-010.1207
11013TMSB15AP79T-EHumanEsophagusESCC3.33e-561.53e+000.1154
11013TMSB15AP128T-EHumanEsophagusESCC2.76e-125.90e-010.1241
11013TMSB15AP130T-EHumanEsophagusESCC5.02e-298.93e-010.1676
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0043254111EsophagusESCCregulation of protein-containing complex assembly278/8552428/187233.81e-162.77e-14278
GO:1902903111EsophagusESCCregulation of supramolecular fiber organization237/8552383/187239.06e-112.75e-09237
GO:0010639110EsophagusESCCnegative regulation of organelle organization215/8552348/187238.20e-102.01e-08215
GO:0045185111EsophagusESCCmaintenance of protein location71/855294/187233.41e-097.24e-0871
GO:0051235110EsophagusESCCmaintenance of location200/8552327/187231.01e-082.02e-07200
GO:0032507110EsophagusESCCmaintenance of protein location in cell52/855265/187231.41e-082.77e-0752
GO:0051258111EsophagusESCCprotein polymerization183/8552297/187231.94e-083.75e-07183
GO:000701527EsophagusESCCactin filament organization259/8552442/187232.37e-084.50e-07259
GO:003253520EsophagusESCCregulation of cellular component size227/8552383/187234.77e-088.60e-07227
GO:0032970111EsophagusESCCregulation of actin filament-based process231/8552397/187232.91e-074.20e-06231
GO:0032956111EsophagusESCCregulation of actin cytoskeleton organization210/8552358/187234.40e-076.00e-06210
GO:0032271111EsophagusESCCregulation of protein polymerization143/8552233/187239.21e-071.17e-05143
GO:011005327EsophagusESCCregulation of actin filament organization166/8552278/187231.54e-061.85e-05166
GO:000815420EsophagusESCCactin polymerization or depolymerization130/8552218/187232.19e-051.88e-04130
GO:0030041110EsophagusESCCactin filament polymerization114/8552191/187236.46e-054.92e-04114
GO:0051651111EsophagusESCCmaintenance of location in cell126/8552214/187236.57e-055.00e-04126
GO:000806419EsophagusESCCregulation of actin polymerization or depolymerization112/8552188/187238.31e-056.06e-04112
GO:003083218EsophagusESCCregulation of actin filament length112/8552189/187231.13e-047.85e-04112
GO:003083320EsophagusESCCregulation of actin filament polymerization103/8552172/187231.19e-048.15e-04103
GO:0031333110EsophagusESCCnegative regulation of protein-containing complex assembly86/8552141/187231.74e-041.14e-0386
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TMSB15ASNVMissense_Mutationc.103N>Cp.Ile35Leup.I35LP0CG34protein_codingdeleterious(0.02)benign(0.005)TCGA-E2-A1B4-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyarimidexSD
TMSB15ASNVMissense_Mutationc.32N>Tp.Glu11Valp.E11VP0CG34protein_codingdeleterious(0.01)possibly_damaging(0.806)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
TMSB15ASNVMissense_Mutationnovelc.61N>Gp.Thr21Alap.T21AP0CG34protein_codingtolerated(0.05)benign(0.013)TCGA-DI-A1BU-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelSD
TMSB15ASNVMissense_Mutationrs782471974c.47N>Tp.Ser16Leup.S16LP0CG34protein_codingtolerated(0.14)benign(0.187)TCGA-DE-A4M8-01Thyroidthyroid carcinomaFemale<65III/IVUnknownUnknownSD
TMSB15ASNVMissense_Mutationrs782183922c.29T>Ap.Val10Glup.V10EP0CG34protein_codingdeleterious(0)probably_damaging(0.966)TCGA-EM-A4FO-01Thyroidthyroid carcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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