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Gene: TMSB10 |
Gene summary for TMSB10 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMSB10 | Gene ID | 9168 |
Gene name | thymosin beta 10 | |
Gene Alias | MIG12 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | P63313 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9168 | TMSB10 | GSM4909281 | Human | Breast | IDC | 7.74e-11 | 1.80e-01 | 0.21 |
9168 | TMSB10 | GSM4909282 | Human | Breast | IDC | 1.66e-06 | 1.35e-01 | -0.0288 |
9168 | TMSB10 | GSM4909285 | Human | Breast | IDC | 3.52e-13 | -1.82e-01 | 0.21 |
9168 | TMSB10 | GSM4909286 | Human | Breast | IDC | 1.94e-15 | -1.80e-01 | 0.1081 |
9168 | TMSB10 | GSM4909287 | Human | Breast | IDC | 1.65e-10 | 2.09e-01 | 0.2057 |
9168 | TMSB10 | GSM4909289 | Human | Breast | IDC | 1.91e-05 | 3.10e-01 | 0.1064 |
9168 | TMSB10 | GSM4909290 | Human | Breast | IDC | 1.48e-32 | 3.55e-01 | 0.2096 |
9168 | TMSB10 | GSM4909291 | Human | Breast | IDC | 6.70e-16 | 2.96e-01 | 0.1753 |
9168 | TMSB10 | GSM4909293 | Human | Breast | IDC | 5.55e-37 | 2.98e-01 | 0.1581 |
9168 | TMSB10 | GSM4909294 | Human | Breast | IDC | 6.36e-78 | 4.37e-01 | 0.2022 |
9168 | TMSB10 | GSM4909296 | Human | Breast | IDC | 2.69e-08 | 1.69e-01 | 0.1524 |
9168 | TMSB10 | GSM4909297 | Human | Breast | IDC | 2.75e-09 | -3.14e-01 | 0.1517 |
9168 | TMSB10 | GSM4909301 | Human | Breast | IDC | 3.39e-04 | -1.78e-01 | 0.1577 |
9168 | TMSB10 | GSM4909302 | Human | Breast | IDC | 5.58e-12 | -2.40e-01 | 0.1545 |
9168 | TMSB10 | GSM4909304 | Human | Breast | IDC | 4.12e-02 | 1.10e-01 | 0.1636 |
9168 | TMSB10 | GSM4909308 | Human | Breast | IDC | 1.62e-26 | -2.89e-01 | 0.158 |
9168 | TMSB10 | GSM4909309 | Human | Breast | IDC | 1.89e-05 | 1.29e-01 | 0.0483 |
9168 | TMSB10 | GSM4909311 | Human | Breast | IDC | 1.51e-15 | 1.06e-01 | 0.1534 |
9168 | TMSB10 | GSM4909315 | Human | Breast | IDC | 2.14e-131 | 5.83e-01 | 0.21 |
9168 | TMSB10 | GSM4909316 | Human | Breast | IDC | 9.61e-52 | 6.16e-01 | 0.21 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00451859 | Breast | Precancer | maintenance of protein location | 19/1080 | 94/18723 | 1.43e-06 | 5.35e-05 | 19 |
GO:00432549 | Breast | Precancer | regulation of protein-containing complex assembly | 50/1080 | 428/18723 | 1.63e-06 | 5.97e-05 | 50 |
GO:00512358 | Breast | Precancer | maintenance of location | 40/1080 | 327/18723 | 5.85e-06 | 1.71e-04 | 40 |
GO:00516519 | Breast | Precancer | maintenance of location in cell | 30/1080 | 214/18723 | 5.91e-06 | 1.71e-04 | 30 |
GO:00325076 | Breast | Precancer | maintenance of protein location in cell | 14/1080 | 65/18723 | 1.59e-05 | 3.89e-04 | 14 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00070159 | Breast | Precancer | actin filament organization | 44/1080 | 442/18723 | 3.02e-04 | 4.35e-03 | 44 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00313338 | Breast | Precancer | negative regulation of protein-containing complex assembly | 18/1080 | 141/18723 | 1.27e-03 | 1.35e-02 | 18 |
GO:01100539 | Breast | Precancer | regulation of actin filament organization | 29/1080 | 278/18723 | 1.50e-03 | 1.55e-02 | 29 |
GO:004325414 | Breast | IDC | regulation of protein-containing complex assembly | 61/1434 | 428/18723 | 1.77e-06 | 7.31e-05 | 61 |
GO:005165114 | Breast | IDC | maintenance of location in cell | 37/1434 | 214/18723 | 2.39e-06 | 9.35e-05 | 37 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:004518514 | Breast | IDC | maintenance of protein location | 21/1434 | 94/18723 | 6.69e-06 | 2.05e-04 | 21 |
GO:190290314 | Breast | IDC | regulation of supramolecular fiber organization | 54/1434 | 383/18723 | 9.40e-06 | 2.66e-04 | 54 |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:003250714 | Breast | IDC | maintenance of protein location in cell | 16/1434 | 65/18723 | 2.29e-05 | 5.51e-04 | 16 |
GO:003295614 | Breast | IDC | regulation of actin cytoskeleton organization | 48/1434 | 358/18723 | 1.03e-04 | 1.96e-03 | 48 |
GO:000701514 | Breast | IDC | actin filament organization | 55/1434 | 442/18723 | 2.45e-04 | 3.84e-03 | 55 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMSB10 | SNV | Missense_Mutation | novel | c.129N>G | p.Ile43Met | p.I43M | P63313 | protein_coding | tolerated_low_confidence(0.08) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMSB10 | SNV | Missense_Mutation | novel | c.25G>A | p.Glu9Lys | p.E9K | P63313 | protein_coding | deleterious(0.02) | benign(0.355) | TCGA-CV-7261-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9168 | TMSB10 | NA | RETINOIDS | 2059565,2169566,1846397,1315216 | ||
9168 | TMSB10 | NA | PMSG | 1989873 | ||
9168 | TMSB10 | NA | MELATONIN | MELATONIN | 12188030 |
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