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Gene: TMPRSS11D |
Gene summary for TMPRSS11D |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMPRSS11D | Gene ID | 9407 |
| Gene name | transmembrane serine protease 11D | |
| Gene Alias | ASP | |
| Cytomap | 4q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | O60235 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9407 | TMPRSS11D | LZE8T | Human | Esophagus | ESCC | 6.32e-12 | 3.70e-01 | 0.067 |
| 9407 | TMPRSS11D | LZE20T | Human | Esophagus | ESCC | 4.89e-12 | 5.41e-01 | 0.0662 |
| 9407 | TMPRSS11D | LZE21T | Human | Esophagus | ESCC | 1.58e-11 | 5.86e-01 | 0.0655 |
| 9407 | TMPRSS11D | P1T-E | Human | Esophagus | ESCC | 1.03e-02 | 8.63e-01 | 0.0875 |
| 9407 | TMPRSS11D | P11T-E | Human | Esophagus | ESCC | 5.83e-09 | 3.67e-01 | 0.1426 |
| 9407 | TMPRSS11D | P21T-E | Human | Esophagus | ESCC | 6.19e-08 | 2.02e-01 | 0.1617 |
| 9407 | TMPRSS11D | P23T-E | Human | Esophagus | ESCC | 2.09e-14 | 4.85e-01 | 0.108 |
| 9407 | TMPRSS11D | P28T-E | Human | Esophagus | ESCC | 1.12e-25 | 6.52e-01 | 0.1149 |
| 9407 | TMPRSS11D | P30T-E | Human | Esophagus | ESCC | 1.61e-07 | 3.20e-01 | 0.137 |
| 9407 | TMPRSS11D | P36T-E | Human | Esophagus | ESCC | 1.27e-02 | 1.13e-01 | 0.1187 |
| 9407 | TMPRSS11D | P48T-E | Human | Esophagus | ESCC | 6.73e-06 | 3.06e-01 | 0.0959 |
| 9407 | TMPRSS11D | P49T-E | Human | Esophagus | ESCC | 5.27e-13 | 7.32e-01 | 0.1768 |
| 9407 | TMPRSS11D | P62T-E | Human | Esophagus | ESCC | 1.36e-34 | 7.68e-01 | 0.1302 |
| 9407 | TMPRSS11D | P84T-E | Human | Esophagus | ESCC | 8.55e-09 | 7.17e-01 | 0.0933 |
| 9407 | TMPRSS11D | P107T-E | Human | Esophagus | ESCC | 1.12e-13 | 5.31e-01 | 0.171 |
| 9407 | TMPRSS11D | P127T-E | Human | Esophagus | ESCC | 9.18e-07 | 1.88e-01 | 0.0826 |
| 9407 | TMPRSS11D | P128T-E | Human | Esophagus | ESCC | 4.35e-19 | 7.19e-01 | 0.1241 |
| 9407 | TMPRSS11D | C04 | Human | Oral cavity | OSCC | 1.10e-06 | 6.75e-01 | 0.2633 |
| 9407 | TMPRSS11D | C30 | Human | Oral cavity | OSCC | 3.30e-18 | 7.78e-01 | 0.3055 |
| 9407 | TMPRSS11D | C38 | Human | Oral cavity | OSCC | 5.38e-11 | 4.94e-01 | 0.172 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
| hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
| hsa0516418 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
| hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMPRSS11D | SNV | Missense_Mutation | c.28N>G | p.Thr10Ala | p.T10A | O60235 | protein_coding | tolerated(0.91) | benign(0) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | |
| TMPRSS11D | SNV | Missense_Mutation | novel | c.277T>G | p.Leu93Val | p.L93V | O60235 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMPRSS11D | insertion | Frame_Shift_Ins | novel | c.1110_1111insACAG | p.Pro371ThrfsTer29 | p.P371Tfs*29 | O60235 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| TMPRSS11D | deletion | Frame_Shift_Del | c.294_295delCA | p.Ile98MetfsTer12 | p.I98Mfs*12 | O60235 | protein_coding | TCGA-AR-A250-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
| TMPRSS11D | SNV | Missense_Mutation | c.163C>G | p.Gln55Glu | p.Q55E | O60235 | protein_coding | tolerated(0.82) | benign(0.003) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
| TMPRSS11D | SNV | Missense_Mutation | c.73N>A | p.Ala25Thr | p.A25T | O60235 | protein_coding | tolerated(0.22) | benign(0.34) | TCGA-AA-3509-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TMPRSS11D | SNV | Missense_Mutation | c.830G>T | p.Arg277Ile | p.R277I | O60235 | protein_coding | deleterious(0) | benign(0.062) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| TMPRSS11D | SNV | Missense_Mutation | c.532N>T | p.Asp178Tyr | p.D178Y | O60235 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| TMPRSS11D | SNV | Missense_Mutation | c.65N>C | p.Ile22Thr | p.I22T | O60235 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-AY-6386-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fu | SD | |
| TMPRSS11D | SNV | Missense_Mutation | novel | c.794N>C | p.Lys265Thr | p.K265T | O60235 | protein_coding | tolerated(0.34) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 9407 | TMPRSS11D | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166870 | ||
| 9407 | TMPRSS11D | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166825 |
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