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Gene: TMPRSS11B |
Gene summary for TMPRSS11B |
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Gene information | Species | Human | Gene symbol | TMPRSS11B | Gene ID | 132724 |
Gene name | transmembrane serine protease 11B | |
Gene Alias | HATL5 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q86T26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132724 | TMPRSS11B | HCC1 | Human | Liver | HCC | 1.76e-16 | 1.10e+00 | 0.5336 |
132724 | TMPRSS11B | HCC2 | Human | Liver | HCC | 3.20e-35 | 1.88e+00 | 0.5341 |
132724 | TMPRSS11B | HCC5 | Human | Liver | HCC | 4.37e-46 | 2.06e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMPRSS11B | SNV | Missense_Mutation | c.647N>A | p.Ser216Asn | p.S216N | Q86T26 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMPRSS11B | SNV | Missense_Mutation | c.499N>G | p.Thr167Ala | p.T167A | Q86T26 | protein_coding | tolerated(0.13) | benign(0) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
TMPRSS11B | SNV | Missense_Mutation | c.929N>T | p.Gly310Val | p.G310V | Q86T26 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMPRSS11B | SNV | Missense_Mutation | c.95N>C | p.Ile32Thr | p.I32T | Q86T26 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMPRSS11B | SNV | Missense_Mutation | c.37C>T | p.Pro13Ser | p.P13S | Q86T26 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMPRSS11B | SNV | Missense_Mutation | c.1177N>G | p.Lys393Glu | p.K393E | Q86T26 | protein_coding | tolerated(0.2) | benign(0.027) | TCGA-D5-6932-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMPRSS11B | SNV | Missense_Mutation | novel | c.392N>C | p.Ile131Thr | p.I131T | Q86T26 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMPRSS11B | SNV | Missense_Mutation | c.29G>T | p.Arg10Ile | p.R10I | Q86T26 | protein_coding | deleterious(0.02) | benign(0.118) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
TMPRSS11B | SNV | Missense_Mutation | novel | c.567N>C | p.Lys189Asn | p.K189N | Q86T26 | protein_coding | tolerated(0.34) | benign(0.207) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMPRSS11B | SNV | Missense_Mutation | novel | c.964N>A | p.Leu322Ile | p.L322I | Q86T26 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3EM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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