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Gene: TMEM98 |
Gene summary for TMEM98 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM98 | Gene ID | 26022 |
| Gene name | transmembrane protein 98 | |
| Gene Alias | TADA1 | |
| Cytomap | 17q11.2 | |
| Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9Y2Y6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 26022 | TMEM98 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.12e-03 | 2.53e-01 | 0.0155 |
| 26022 | TMEM98 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.20e-07 | 4.41e-01 | -0.1808 |
| 26022 | TMEM98 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.44e-03 | 4.79e-01 | -0.0811 |
| 26022 | TMEM98 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.25e-09 | 6.80e-01 | -0.1088 |
| 26022 | TMEM98 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.93e-32 | 8.76e-01 | -0.1954 |
| 26022 | TMEM98 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.67e-08 | 1.04e+00 | -0.2602 |
| 26022 | TMEM98 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.94e-02 | 2.64e-01 | -0.1207 |
| 26022 | TMEM98 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.29e-03 | 4.92e-01 | -0.1526 |
| 26022 | TMEM98 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.49e-09 | 4.56e-01 | -0.1464 |
| 26022 | TMEM98 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.55e-07 | 3.51e-01 | -0.1001 |
| 26022 | TMEM98 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.29e-07 | 4.71e-01 | -0.059 |
| 26022 | TMEM98 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.55e-05 | 8.17e-01 | -0.1706 |
| 26022 | TMEM98 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.55e-08 | 1.02e+00 | -0.2061 |
| 26022 | TMEM98 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.27e-10 | 7.47e-01 | -0.0179 |
| 26022 | TMEM98 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.92e-18 | 6.06e-01 | 0.096 |
| 26022 | TMEM98 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.05e-07 | 6.50e-01 | 0.0528 |
| 26022 | TMEM98 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.44e-03 | 6.08e-01 | 0.0131 |
| 26022 | TMEM98 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.66e-06 | 9.36e-01 | 0.0171 |
| 26022 | TMEM98 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.36e-05 | 2.93e-01 | 0.0674 |
| 26022 | TMEM98 | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.57e-06 | 9.24e-01 | -0.0124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
| GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
| GO:1903828 | Colorectum | AD | negative regulation of cellular protein localization | 39/3918 | 117/18723 | 1.18e-03 | 1.06e-02 | 39 |
| GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
| GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
| GO:19001801 | Colorectum | SER | regulation of protein localization to nucleus | 46/2897 | 136/18723 | 8.50e-08 | 5.27e-06 | 46 |
| GO:00458611 | Colorectum | SER | negative regulation of proteolysis | 88/2897 | 351/18723 | 1.74e-06 | 7.50e-05 | 88 |
| GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
| GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
| GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
| GO:19038281 | Colorectum | SER | negative regulation of cellular protein localization | 30/2897 | 117/18723 | 2.96e-03 | 2.62e-02 | 30 |
| GO:19001802 | Colorectum | MSS | regulation of protein localization to nucleus | 54/3467 | 136/18723 | 6.20e-09 | 3.95e-07 | 54 |
| GO:00345042 | Colorectum | MSS | protein localization to nucleus | 92/3467 | 290/18723 | 3.66e-08 | 1.98e-06 | 92 |
| GO:00458612 | Colorectum | MSS | negative regulation of proteolysis | 97/3467 | 351/18723 | 1.57e-05 | 3.54e-04 | 97 |
| GO:00507671 | Colorectum | MSS | regulation of neurogenesis | 94/3467 | 364/18723 | 3.12e-04 | 4.06e-03 | 94 |
| GO:19038282 | Colorectum | MSS | negative regulation of cellular protein localization | 36/3467 | 117/18723 | 9.19e-04 | 9.34e-03 | 36 |
| GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
| GO:0050768 | Colorectum | MSS | negative regulation of neurogenesis | 39/3467 | 140/18723 | 4.30e-03 | 3.07e-02 | 39 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM98 | SNV | Missense_Mutation | novel | c.176N>A | p.Pro59His | p.P59H | Q9Y2Y6 | protein_coding | tolerated(0.12) | benign(0.232) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM98 | insertion | Nonsense_Mutation | novel | c.610_611insGCTTCAGTTAACTATGTTTAA | p.Ala204delinsGlyPheSerTerLeuCysLeuThr | p.A204delinsGFS*LCLT | Q9Y2Y6 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| TMEM98 | insertion | Frame_Shift_Ins | novel | c.535_536insAATCCAACAATCCCACTCCTTGGTATTTATCCAAA | p.Leu179GlnfsTer13 | p.L179Qfs*13 | Q9Y2Y6 | protein_coding | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
| TMEM98 | SNV | Missense_Mutation | c.196N>A | p.Asp66Asn | p.D66N | Q9Y2Y6 | protein_coding | tolerated(0.07) | benign(0.094) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| TMEM98 | SNV | Missense_Mutation | c.506N>C | p.Leu169Pro | p.L169P | Q9Y2Y6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM98 | SNV | Missense_Mutation | novel | c.578N>A | p.Ala193Asp | p.A193D | Q9Y2Y6 | protein_coding | deleterious(0.01) | possibly_damaging(0.675) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| TMEM98 | SNV | Missense_Mutation | novel | c.268N>A | p.Leu90Ile | p.L90I | Q9Y2Y6 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TMEM98 | SNV | Missense_Mutation | rs753209256 | c.379N>A | p.Asp127Asn | p.D127N | Q9Y2Y6 | protein_coding | deleterious(0.03) | possibly_damaging(0.555) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TMEM98 | SNV | Missense_Mutation | c.544N>A | p.Gly182Ser | p.G182S | Q9Y2Y6 | protein_coding | tolerated(1) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TMEM98 | SNV | Missense_Mutation | novel | c.254N>G | p.Glu85Gly | p.E85G | Q9Y2Y6 | protein_coding | tolerated(0.18) | benign(0.266) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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