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Gene: TMEM92 |
Gene summary for TMEM92 |
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Gene information | Species | Human | Gene symbol | TMEM92 | Gene ID | 162461 |
Gene name | transmembrane protein 92 | |
Gene Alias | TMEM92 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6UXU6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162461 | TMEM92 | LZE24T | Human | Esophagus | ESCC | 3.83e-09 | 2.99e-01 | 0.0596 |
162461 | TMEM92 | P4T-E | Human | Esophagus | ESCC | 6.72e-08 | 2.61e-01 | 0.1323 |
162461 | TMEM92 | P5T-E | Human | Esophagus | ESCC | 3.75e-03 | 8.92e-02 | 0.1327 |
162461 | TMEM92 | P8T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.84e-01 | 0.0889 |
162461 | TMEM92 | P11T-E | Human | Esophagus | ESCC | 1.55e-05 | 2.35e-01 | 0.1426 |
162461 | TMEM92 | P15T-E | Human | Esophagus | ESCC | 2.08e-07 | 8.60e-02 | 0.1149 |
162461 | TMEM92 | P21T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.00e-01 | 0.1617 |
162461 | TMEM92 | P24T-E | Human | Esophagus | ESCC | 2.58e-06 | 1.18e-01 | 0.1287 |
162461 | TMEM92 | P26T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.30e-01 | 0.1276 |
162461 | TMEM92 | P27T-E | Human | Esophagus | ESCC | 1.13e-09 | 7.37e-02 | 0.1055 |
162461 | TMEM92 | P37T-E | Human | Esophagus | ESCC | 4.09e-17 | 3.43e-01 | 0.1371 |
162461 | TMEM92 | P38T-E | Human | Esophagus | ESCC | 1.24e-04 | 2.18e-01 | 0.127 |
162461 | TMEM92 | P39T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.49e-02 | 0.0894 |
162461 | TMEM92 | P40T-E | Human | Esophagus | ESCC | 2.11e-05 | 2.11e-01 | 0.109 |
162461 | TMEM92 | P47T-E | Human | Esophagus | ESCC | 4.40e-09 | 2.38e-01 | 0.1067 |
162461 | TMEM92 | P49T-E | Human | Esophagus | ESCC | 1.04e-17 | 1.10e+00 | 0.1768 |
162461 | TMEM92 | P52T-E | Human | Esophagus | ESCC | 5.11e-03 | 7.59e-02 | 0.1555 |
162461 | TMEM92 | P57T-E | Human | Esophagus | ESCC | 2.56e-16 | 3.03e-01 | 0.0926 |
162461 | TMEM92 | P61T-E | Human | Esophagus | ESCC | 2.58e-09 | 2.13e-01 | 0.099 |
162461 | TMEM92 | P62T-E | Human | Esophagus | ESCC | 1.11e-10 | 2.53e-01 | 0.1302 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM92 | SNV | Missense_Mutation | rs775454127 | c.446G>A | p.Gly149Glu | p.G149E | Q6UXU6 | protein_coding | tolerated(0.08) | benign(0.018) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM92 | insertion | Frame_Shift_Ins | novel | c.244_245insCTTTGGGTGC | p.Asn82ThrfsTer44 | p.N82Tfs*44 | Q6UXU6 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM92 | insertion | Frame_Shift_Ins | novel | c.245_246insGTCCTTGGAGGGGC | p.Asn82LysfsTer47 | p.N82Kfs*47 | Q6UXU6 | protein_coding | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
TMEM92 | SNV | Missense_Mutation | rs373936984 | c.242N>A | p.Arg81His | p.R81H | Q6UXU6 | protein_coding | tolerated(0.53) | possibly_damaging(0.555) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM92 | SNV | Missense_Mutation | rs373936984 | c.242G>A | p.Arg81His | p.R81H | Q6UXU6 | protein_coding | tolerated(0.53) | possibly_damaging(0.555) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM92 | SNV | Missense_Mutation | novel | c.407N>A | p.Pro136Gln | p.P136Q | Q6UXU6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
TMEM92 | SNV | Missense_Mutation | novel | c.253N>A | p.Glu85Lys | p.E85K | Q6UXU6 | protein_coding | tolerated(0.49) | benign(0.001) | TCGA-AP-A1DH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM92 | SNV | Missense_Mutation | novel | c.161G>A | p.Gly54Asp | p.G54D | Q6UXU6 | protein_coding | tolerated(0.29) | benign(0.046) | TCGA-B5-A0JT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Hormone Therapy | megace | SD |
TMEM92 | SNV | Missense_Mutation | novel | c.80N>C | p.Lys27Thr | p.K27T | Q6UXU6 | protein_coding | tolerated(0.51) | benign(0.001) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TMEM92 | SNV | Missense_Mutation | c.400N>C | p.Thr134Pro | p.T134P | Q6UXU6 | protein_coding | tolerated(0.19) | benign(0.367) | TCGA-BS-A0TI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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