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Gene: TMEM87A |
Gene summary for TMEM87A |
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Gene information | Species | Human | Gene symbol | TMEM87A | Gene ID | 25963 |
Gene name | transmembrane protein 87A | |
Gene Alias | TMEM87A | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NBN3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25963 | TMEM87A | CA_HPV_1 | Human | Cervix | CC | 1.04e-02 | -5.91e-02 | 0.0264 |
25963 | TMEM87A | CCI_1 | Human | Cervix | CC | 4.65e-02 | 5.85e-01 | 0.528 |
25963 | TMEM87A | CCI_2 | Human | Cervix | CC | 4.86e-04 | 7.14e-01 | 0.5249 |
25963 | TMEM87A | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.65e-20 | -5.94e-01 | 0.0155 |
25963 | TMEM87A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.24e-05 | -9.11e-01 | 0.0216 |
25963 | TMEM87A | HTA11_347_2000001011 | Human | Colorectum | AD | 5.60e-03 | 3.96e-01 | -0.1954 |
25963 | TMEM87A | HTA11_866_3004761011 | Human | Colorectum | AD | 3.19e-03 | -3.81e-01 | 0.096 |
25963 | TMEM87A | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.69e-02 | -7.37e-01 | 0.0451 |
25963 | TMEM87A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.14e-06 | 8.06e-01 | 0.3487 |
25963 | TMEM87A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.73e-03 | 5.43e-01 | 0.281 |
25963 | TMEM87A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.62e-02 | -3.80e-01 | 0.3859 |
25963 | TMEM87A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.10e-02 | -4.79e-01 | 0.2585 |
25963 | TMEM87A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.24e-09 | -5.41e-01 | 0.3005 |
25963 | TMEM87A | F007 | Human | Colorectum | FAP | 3.37e-12 | -6.64e-01 | 0.1176 |
25963 | TMEM87A | A002-C-010 | Human | Colorectum | FAP | 3.08e-02 | -1.34e-01 | 0.242 |
25963 | TMEM87A | A001-C-207 | Human | Colorectum | FAP | 5.79e-06 | -3.24e-01 | 0.1278 |
25963 | TMEM87A | A015-C-203 | Human | Colorectum | FAP | 2.12e-34 | -4.03e-01 | -0.1294 |
25963 | TMEM87A | A015-C-204 | Human | Colorectum | FAP | 5.02e-08 | -2.72e-01 | -0.0228 |
25963 | TMEM87A | A014-C-040 | Human | Colorectum | FAP | 7.32e-07 | -2.58e-01 | -0.1184 |
25963 | TMEM87A | A002-C-201 | Human | Colorectum | FAP | 1.53e-15 | -2.69e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0042147 | Colorectum | AD | retrograde transport, endosome to Golgi | 37/3918 | 91/18723 | 1.46e-05 | 3.14e-04 | 37 |
GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
GO:00164822 | Colorectum | MSS | cytosolic transport | 59/3467 | 168/18723 | 2.29e-07 | 9.79e-06 | 59 |
GO:00421471 | Colorectum | MSS | retrograde transport, endosome to Golgi | 33/3467 | 91/18723 | 4.78e-05 | 8.71e-04 | 33 |
GO:00164823 | Colorectum | FAP | cytosolic transport | 47/2622 | 168/18723 | 1.58e-06 | 6.72e-05 | 47 |
GO:00161973 | Colorectum | FAP | endosomal transport | 56/2622 | 230/18723 | 1.79e-05 | 4.53e-04 | 56 |
GO:00421472 | Colorectum | FAP | retrograde transport, endosome to Golgi | 26/2622 | 91/18723 | 2.21e-04 | 3.14e-03 | 26 |
GO:00164824 | Colorectum | CRC | cytosolic transport | 45/2078 | 168/18723 | 1.22e-08 | 2.52e-06 | 45 |
GO:00161974 | Colorectum | CRC | endosomal transport | 49/2078 | 230/18723 | 5.07e-06 | 2.05e-04 | 49 |
GO:00421473 | Colorectum | CRC | retrograde transport, endosome to Golgi | 24/2078 | 91/18723 | 3.88e-05 | 9.49e-04 | 24 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:00421477 | Esophagus | ESCC | retrograde transport, endosome to Golgi | 63/8552 | 91/18723 | 4.58e-06 | 4.87e-05 | 63 |
GO:00164825 | Liver | NAFLD | cytosolic transport | 34/1882 | 168/18723 | 5.52e-05 | 1.25e-03 | 34 |
GO:00161975 | Liver | NAFLD | endosomal transport | 41/1882 | 230/18723 | 2.02e-04 | 3.53e-03 | 41 |
GO:00421474 | Liver | NAFLD | retrograde transport, endosome to Golgi | 19/1882 | 91/18723 | 1.55e-03 | 1.67e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM87A | SNV | Missense_Mutation | c.681N>A | p.Met227Ile | p.M227I | Q8NBN3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A2-A25B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | PD | |
TMEM87A | SNV | Missense_Mutation | c.842A>G | p.Gln281Arg | p.Q281R | Q8NBN3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E2-A15P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
TMEM87A | SNV | Missense_Mutation | novel | c.188C>T | p.Thr63Ile | p.T63I | Q8NBN3 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-OL-A5S0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | CR |
TMEM87A | insertion | Nonsense_Mutation | novel | c.1336_1337insCTTAGTTTCCTTTCTATATACTGAGGGGGAATTAAACCCAG | p.Arg446ProfsTer2 | p.R446Pfs*2 | Q8NBN3 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
TMEM87A | SNV | Missense_Mutation | rs773068113 | c.413C>T | p.Ser138Phe | p.S138F | Q8NBN3 | protein_coding | tolerated(0.66) | benign(0.023) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
TMEM87A | SNV | Missense_Mutation | c.298G>A | p.Glu100Lys | p.E100K | Q8NBN3 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM87A | SNV | Missense_Mutation | novel | c.1468G>C | p.Glu490Gln | p.E490Q | Q8NBN3 | protein_coding | deleterious(0.01) | probably_damaging(0.941) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TMEM87A | SNV | Missense_Mutation | c.1456C>T | p.Pro486Ser | p.P486S | Q8NBN3 | protein_coding | tolerated(0.45) | possibly_damaging(0.895) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM87A | SNV | Missense_Mutation | novel | c.40N>A | p.Leu14Ile | p.L14I | Q8NBN3 | protein_coding | tolerated(0.11) | benign(0.017) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TMEM87A | SNV | Missense_Mutation | rs749148379 | c.913N>T | p.Arg305Cys | p.R305C | Q8NBN3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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