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Gene: TMEM68 |
Gene summary for TMEM68 |
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Gene information | Species | Human | Gene symbol | TMEM68 | Gene ID | 137695 |
Gene name | transmembrane protein 68 | |
Gene Alias | TMEM68 | |
Cytomap | 8q12.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96MH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
137695 | TMEM68 | LZE2D | Human | Esophagus | HGIN | 2.93e-02 | 2.54e-01 | 0.0642 |
137695 | TMEM68 | LZE2T | Human | Esophagus | ESCC | 8.67e-03 | 3.47e-01 | 0.082 |
137695 | TMEM68 | LZE4T | Human | Esophagus | ESCC | 1.28e-11 | 2.68e-01 | 0.0811 |
137695 | TMEM68 | LZE7T | Human | Esophagus | ESCC | 6.12e-06 | 2.83e-01 | 0.0667 |
137695 | TMEM68 | LZE8T | Human | Esophagus | ESCC | 1.71e-07 | 3.28e-01 | 0.067 |
137695 | TMEM68 | LZE20T | Human | Esophagus | ESCC | 5.24e-11 | 2.74e-01 | 0.0662 |
137695 | TMEM68 | LZE24T | Human | Esophagus | ESCC | 4.35e-12 | 3.24e-01 | 0.0596 |
137695 | TMEM68 | LZE21T | Human | Esophagus | ESCC | 2.63e-06 | 2.76e-01 | 0.0655 |
137695 | TMEM68 | P1T-E | Human | Esophagus | ESCC | 2.29e-05 | 1.36e-01 | 0.0875 |
137695 | TMEM68 | P2T-E | Human | Esophagus | ESCC | 3.71e-26 | 5.70e-01 | 0.1177 |
137695 | TMEM68 | P4T-E | Human | Esophagus | ESCC | 2.26e-32 | 5.62e-01 | 0.1323 |
137695 | TMEM68 | P5T-E | Human | Esophagus | ESCC | 5.32e-07 | 7.21e-02 | 0.1327 |
137695 | TMEM68 | P8T-E | Human | Esophagus | ESCC | 2.35e-16 | 2.88e-01 | 0.0889 |
137695 | TMEM68 | P9T-E | Human | Esophagus | ESCC | 3.21e-13 | 2.04e-01 | 0.1131 |
137695 | TMEM68 | P10T-E | Human | Esophagus | ESCC | 8.73e-25 | 4.90e-01 | 0.116 |
137695 | TMEM68 | P11T-E | Human | Esophagus | ESCC | 1.89e-09 | 3.73e-01 | 0.1426 |
137695 | TMEM68 | P12T-E | Human | Esophagus | ESCC | 4.94e-27 | 5.83e-01 | 0.1122 |
137695 | TMEM68 | P15T-E | Human | Esophagus | ESCC | 2.54e-19 | 4.49e-01 | 0.1149 |
137695 | TMEM68 | P16T-E | Human | Esophagus | ESCC | 2.03e-51 | 1.04e+00 | 0.1153 |
137695 | TMEM68 | P17T-E | Human | Esophagus | ESCC | 3.48e-08 | 2.47e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM68 | SNV | Missense_Mutation | c.964N>T | p.Arg322Cys | p.R322C | Q96MH6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
TMEM68 | SNV | Missense_Mutation | c.248N>T | p.Ala83Val | p.A83V | Q96MH6 | protein_coding | tolerated(0.24) | benign(0.098) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM68 | SNV | Missense_Mutation | c.420N>A | p.Phe140Leu | p.F140L | Q96MH6 | protein_coding | tolerated(0.12) | benign(0.267) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM68 | SNV | Missense_Mutation | c.680N>T | p.Ala227Val | p.A227V | Q96MH6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM68 | deletion | Frame_Shift_Del | novel | c.684delN | p.Val229CysfsTer44 | p.V229Cfs*44 | Q96MH6 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM68 | SNV | Missense_Mutation | c.680C>T | p.Ala227Val | p.A227V | Q96MH6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM68 | SNV | Missense_Mutation | novel | c.555N>C | p.Glu185Asp | p.E185D | Q96MH6 | protein_coding | tolerated(0.46) | benign(0.02) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM68 | SNV | Missense_Mutation | rs761724186 | c.649N>T | p.Arg217Cys | p.R217C | Q96MH6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM68 | SNV | Missense_Mutation | c.236N>C | p.Val79Ala | p.V79A | Q96MH6 | protein_coding | tolerated(0.56) | benign(0.014) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TMEM68 | SNV | Missense_Mutation | novel | c.559C>A | p.Leu187Met | p.L187M | Q96MH6 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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