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Gene: TMEM63B |
Gene summary for TMEM63B |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM63B | Gene ID | 55362 |
Gene name | transmembrane protein 63B | |
Gene Alias | C6orf110 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5T3F8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55362 | TMEM63B | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.88e-02 | 3.71e-01 | -0.1808 |
55362 | TMEM63B | HTA11_347_2000001011 | Human | Colorectum | AD | 1.34e-15 | 5.85e-01 | -0.1954 |
55362 | TMEM63B | HTA11_411_2000001011 | Human | Colorectum | SER | 1.31e-03 | 9.71e-01 | -0.2602 |
55362 | TMEM63B | HTA11_696_2000001011 | Human | Colorectum | AD | 2.06e-07 | 3.62e-01 | -0.1464 |
55362 | TMEM63B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.71e-02 | 3.33e-01 | -0.059 |
55362 | TMEM63B | A015-C-203 | Human | Colorectum | FAP | 3.76e-03 | -1.40e-01 | -0.1294 |
55362 | TMEM63B | A002-C-205 | Human | Colorectum | FAP | 5.58e-05 | -2.05e-01 | -0.1236 |
55362 | TMEM63B | A015-C-104 | Human | Colorectum | FAP | 1.42e-06 | -1.98e-01 | -0.1899 |
55362 | TMEM63B | A002-C-016 | Human | Colorectum | FAP | 4.04e-05 | -1.35e-01 | 0.0521 |
55362 | TMEM63B | A002-C-116 | Human | Colorectum | FAP | 6.38e-06 | -1.58e-01 | -0.0452 |
55362 | TMEM63B | A014-C-008 | Human | Colorectum | FAP | 5.92e-03 | -2.19e-01 | -0.191 |
55362 | TMEM63B | A018-E-020 | Human | Colorectum | FAP | 2.15e-02 | -1.39e-01 | -0.2034 |
55362 | TMEM63B | F034 | Human | Colorectum | FAP | 4.17e-05 | -1.84e-01 | -0.0665 |
55362 | TMEM63B | LZE2T | Human | Esophagus | ESCC | 4.93e-10 | 1.63e+00 | 0.082 |
55362 | TMEM63B | LZE4T | Human | Esophagus | ESCC | 1.55e-10 | 2.77e-01 | 0.0811 |
55362 | TMEM63B | LZE5T | Human | Esophagus | ESCC | 2.95e-04 | 2.77e-01 | 0.0514 |
55362 | TMEM63B | LZE8T | Human | Esophagus | ESCC | 3.24e-06 | 2.51e-01 | 0.067 |
55362 | TMEM63B | LZE20T | Human | Esophagus | ESCC | 3.24e-08 | 3.32e-01 | 0.0662 |
55362 | TMEM63B | LZE22T | Human | Esophagus | ESCC | 1.36e-12 | 4.52e-01 | 0.068 |
55362 | TMEM63B | LZE24T | Human | Esophagus | ESCC | 4.38e-19 | 4.96e-01 | 0.0596 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM63B | SNV | Missense_Mutation | novel | c.1975N>A | p.Asp659Asn | p.D659N | Q5T3F8 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A2-A0CO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
TMEM63B | SNV | Missense_Mutation | c.179N>T | p.Ser60Phe | p.S60F | Q5T3F8 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM63B | SNV | Missense_Mutation | c.575N>C | p.Arg192Thr | p.R192T | Q5T3F8 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
TMEM63B | SNV | Missense_Mutation | c.1248N>C | p.Gln416His | p.Q416H | Q5T3F8 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
TMEM63B | SNV | Missense_Mutation | novel | c.515T>A | p.Ile172Asn | p.I172N | Q5T3F8 | protein_coding | deleterious(0) | possibly_damaging(0.571) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM63B | SNV | Missense_Mutation | rs143307278 | c.1180C>T | p.Arg394Cys | p.R394C | Q5T3F8 | protein_coding | deleterious(0.01) | benign(0.109) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM63B | SNV | Missense_Mutation | c.1105N>A | p.Glu369Lys | p.E369K | Q5T3F8 | protein_coding | tolerated(0.42) | benign(0.401) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM63B | insertion | Frame_Shift_Ins | novel | c.1766_1767insGGGCCTGCTC | p.Met593ArgfsTer155 | p.M593Rfs*155 | Q5T3F8 | protein_coding | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
TMEM63B | SNV | Missense_Mutation | c.1471N>A | p.Leu491Ile | p.L491I | Q5T3F8 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM63B | SNV | Missense_Mutation | c.2059G>A | p.Ala687Thr | p.A687T | Q5T3F8 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-A566-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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