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Gene: TMEM56 |
Gene summary for TMEM56 |
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Gene information | Species | Human | Gene symbol | TMEM56 | Gene ID | 148534 |
Gene name | TLC domain containing 4 | |
Gene Alias | TMEM56 | |
Cytomap | 1p21.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96MV1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148534 | TMEM56 | S43 | Human | Liver | Cirrhotic | 9.14e-03 | -1.54e-01 | -0.0187 |
148534 | TMEM56 | HCC1_Meng | Human | Liver | HCC | 7.97e-68 | 2.32e-02 | 0.0246 |
148534 | TMEM56 | HCC2_Meng | Human | Liver | HCC | 1.04e-07 | -7.82e-02 | 0.0107 |
148534 | TMEM56 | HCC1 | Human | Liver | HCC | 8.84e-14 | 2.68e+00 | 0.5336 |
148534 | TMEM56 | HCC2 | Human | Liver | HCC | 4.73e-27 | 3.34e+00 | 0.5341 |
148534 | TMEM56 | HCC5 | Human | Liver | HCC | 3.82e-13 | 2.12e+00 | 0.4932 |
148534 | TMEM56 | Pt14.b | Human | Liver | HCC | 3.43e-02 | 1.82e-01 | 0.018 |
148534 | TMEM56 | S014 | Human | Liver | HCC | 1.84e-05 | 4.73e-01 | 0.2254 |
148534 | TMEM56 | S015 | Human | Liver | HCC | 7.97e-15 | 8.67e-01 | 0.2375 |
148534 | TMEM56 | S016 | Human | Liver | HCC | 5.89e-06 | 5.41e-01 | 0.2243 |
148534 | TMEM56 | S028 | Human | Liver | HCC | 1.68e-05 | 4.53e-01 | 0.2503 |
148534 | TMEM56 | S029 | Human | Liver | HCC | 1.22e-06 | 5.87e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM56 | SNV | Missense_Mutation | c.42C>G | p.Ile14Met | p.I14M | Q96MV1 | protein_coding | deleterious(0.03) | benign(0.081) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TMEM56 | SNV | Missense_Mutation | novel | c.330N>C | p.Trp110Cys | p.W110C | Q96MV1 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM56 | SNV | Missense_Mutation | novel | c.104C>A | p.Ser35Tyr | p.S35Y | Q96MV1 | protein_coding | deleterious(0.01) | possibly_damaging(0.646) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM56 | SNV | Missense_Mutation | novel | c.772C>A | p.Gln258Lys | p.Q258K | Q96MV1 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM56 | SNV | Missense_Mutation | rs150211570 | c.106N>G | p.Pro36Ala | p.P36A | Q96MV1 | protein_coding | tolerated(0.13) | benign(0.021) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
TMEM56 | insertion | Nonsense_Mutation | novel | c.436_437insAATAGGGTCATTGTAGATGTAGTTAGTTAAGATGAGTTTGTAT | p.Leu146GlnfsTer2 | p.L146Qfs*2 | Q96MV1 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM56 | deletion | Frame_Shift_Del | novel | c.737delC | p.Ser246PhefsTer38 | p.S246Ffs*38 | Q96MV1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TMEM56 | SNV | Missense_Mutation | c.559G>A | p.Val187Met | p.V187M | Q96MV1 | protein_coding | deleterious(0.03) | probably_damaging(0.92) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM56 | SNV | Missense_Mutation | novel | c.290G>A | p.Gly97Asp | p.G97D | Q96MV1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM56 | SNV | Missense_Mutation | c.559G>A | p.Val187Met | p.V187M | Q96MV1 | protein_coding | deleterious(0.03) | probably_damaging(0.92) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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