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Gene: TMEM55B |
Gene summary for TMEM55B |
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Gene information | Species | Human | Gene symbol | TMEM55B | Gene ID | 90809 |
Gene name | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 | |
Gene Alias | C14orf9 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | Q86T03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90809 | TMEM55B | P1T-E | Human | Esophagus | ESCC | 6.28e-05 | 3.91e-01 | 0.0875 |
90809 | TMEM55B | P2T-E | Human | Esophagus | ESCC | 3.38e-26 | 3.52e-01 | 0.1177 |
90809 | TMEM55B | P4T-E | Human | Esophagus | ESCC | 6.84e-38 | 6.78e-01 | 0.1323 |
90809 | TMEM55B | P5T-E | Human | Esophagus | ESCC | 2.40e-17 | 2.87e-01 | 0.1327 |
90809 | TMEM55B | P8T-E | Human | Esophagus | ESCC | 3.06e-28 | 4.23e-01 | 0.0889 |
90809 | TMEM55B | P9T-E | Human | Esophagus | ESCC | 1.39e-16 | 3.23e-01 | 0.1131 |
90809 | TMEM55B | P10T-E | Human | Esophagus | ESCC | 7.28e-29 | 5.28e-01 | 0.116 |
90809 | TMEM55B | P11T-E | Human | Esophagus | ESCC | 4.96e-21 | 5.57e-01 | 0.1426 |
90809 | TMEM55B | P12T-E | Human | Esophagus | ESCC | 1.74e-50 | 9.01e-01 | 0.1122 |
90809 | TMEM55B | P15T-E | Human | Esophagus | ESCC | 1.08e-45 | 9.21e-01 | 0.1149 |
90809 | TMEM55B | P16T-E | Human | Esophagus | ESCC | 6.91e-21 | 3.20e-01 | 0.1153 |
90809 | TMEM55B | P17T-E | Human | Esophagus | ESCC | 3.75e-04 | 2.86e-01 | 0.1278 |
90809 | TMEM55B | P19T-E | Human | Esophagus | ESCC | 5.29e-06 | 4.46e-01 | 0.1662 |
90809 | TMEM55B | P20T-E | Human | Esophagus | ESCC | 1.58e-13 | 3.28e-01 | 0.1124 |
90809 | TMEM55B | P21T-E | Human | Esophagus | ESCC | 4.66e-21 | 3.32e-01 | 0.1617 |
90809 | TMEM55B | P22T-E | Human | Esophagus | ESCC | 1.66e-39 | 6.48e-01 | 0.1236 |
90809 | TMEM55B | P23T-E | Human | Esophagus | ESCC | 6.33e-36 | 8.73e-01 | 0.108 |
90809 | TMEM55B | P24T-E | Human | Esophagus | ESCC | 3.35e-22 | 3.71e-01 | 0.1287 |
90809 | TMEM55B | P26T-E | Human | Esophagus | ESCC | 7.55e-43 | 6.17e-01 | 0.1276 |
90809 | TMEM55B | P27T-E | Human | Esophagus | ESCC | 1.22e-40 | 6.98e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM55B | SNV | Missense_Mutation | rs767405120 | c.662N>T | p.Cys221Phe | p.C221F | Q86T03 | protein_coding | tolerated(0.5) | benign(0.059) | TCGA-E2-A1L6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TMEM55B | SNV | Missense_Mutation | rs767405120 | c.662N>T | p.Cys221Phe | p.C221F | Q86T03 | protein_coding | tolerated(0.5) | benign(0.059) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TMEM55B | SNV | Missense_Mutation | novel | c.467N>T | p.Arg156Ile | p.R156I | Q86T03 | protein_coding | deleterious(0) | possibly_damaging(0.667) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM55B | SNV | Missense_Mutation | c.599G>T | p.Arg200Leu | p.R200L | Q86T03 | protein_coding | deleterious(0) | benign(0.2) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
TMEM55B | SNV | Missense_Mutation | rs776238979 | c.733N>T | p.Arg245Trp | p.R245W | Q86T03 | protein_coding | deleterious(0) | benign(0.112) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM55B | SNV | Missense_Mutation | novel | c.734N>T | p.Arg245Leu | p.R245L | Q86T03 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-A5-A1OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
TMEM55B | SNV | Missense_Mutation | novel | c.726N>C | p.Lys242Asn | p.K242N | Q86T03 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM55B | SNV | Missense_Mutation | novel | c.265A>C | p.Ile89Leu | p.I89L | Q86T03 | protein_coding | deleterious(0.01) | benign(0.209) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM55B | SNV | Missense_Mutation | c.653N>A | p.Arg218Lys | p.R218K | Q86T03 | protein_coding | tolerated(0.1) | probably_damaging(0.953) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TMEM55B | SNV | Missense_Mutation | rs776716699 | c.587N>A | p.Arg196His | p.R196H | Q86T03 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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