![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM51 |
Gene summary for TMEM51 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM51 | Gene ID | 55092 |
Gene name | transmembrane protein 51 | |
Gene Alias | C1orf72 | |
Cytomap | 1p36.21 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024QZ97 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55092 | TMEM51 | CCI_1 | Human | Cervix | CC | 4.07e-03 | 5.99e-01 | 0.528 |
55092 | TMEM51 | CCI_2 | Human | Cervix | CC | 1.01e-08 | 1.17e+00 | 0.5249 |
55092 | TMEM51 | CCI_3 | Human | Cervix | CC | 3.79e-03 | 6.48e-01 | 0.516 |
55092 | TMEM51 | LZE22T | Human | Esophagus | ESCC | 4.17e-02 | 3.13e-01 | 0.068 |
55092 | TMEM51 | LZE24T | Human | Esophagus | ESCC | 1.27e-05 | 2.41e-01 | 0.0596 |
55092 | TMEM51 | LZE21T | Human | Esophagus | ESCC | 3.42e-04 | 1.30e-01 | 0.0655 |
55092 | TMEM51 | P1T-E | Human | Esophagus | ESCC | 3.69e-04 | 2.19e-01 | 0.0875 |
55092 | TMEM51 | P2T-E | Human | Esophagus | ESCC | 1.94e-15 | 3.33e-01 | 0.1177 |
55092 | TMEM51 | P4T-E | Human | Esophagus | ESCC | 2.40e-14 | 1.85e-01 | 0.1323 |
55092 | TMEM51 | P5T-E | Human | Esophagus | ESCC | 7.49e-05 | 8.32e-02 | 0.1327 |
55092 | TMEM51 | P8T-E | Human | Esophagus | ESCC | 1.01e-02 | 1.56e-01 | 0.0889 |
55092 | TMEM51 | P9T-E | Human | Esophagus | ESCC | 1.44e-02 | 5.95e-02 | 0.1131 |
55092 | TMEM51 | P10T-E | Human | Esophagus | ESCC | 2.64e-07 | 2.67e-02 | 0.116 |
55092 | TMEM51 | P11T-E | Human | Esophagus | ESCC | 1.17e-07 | 2.32e-01 | 0.1426 |
55092 | TMEM51 | P12T-E | Human | Esophagus | ESCC | 2.75e-15 | 4.75e-02 | 0.1122 |
55092 | TMEM51 | P15T-E | Human | Esophagus | ESCC | 1.16e-03 | 1.05e-01 | 0.1149 |
55092 | TMEM51 | P16T-E | Human | Esophagus | ESCC | 2.63e-10 | 8.85e-02 | 0.1153 |
55092 | TMEM51 | P21T-E | Human | Esophagus | ESCC | 1.05e-09 | 2.08e-01 | 0.1617 |
55092 | TMEM51 | P22T-E | Human | Esophagus | ESCC | 5.78e-08 | -4.07e-03 | 0.1236 |
55092 | TMEM51 | P23T-E | Human | Esophagus | ESCC | 8.28e-14 | 3.86e-01 | 0.108 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM51 | SNV | Missense_Mutation | c.160N>A | p.Gly54Ser | p.G54S | Q9NW97 | protein_coding | tolerated(0.54) | benign(0.025) | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM51 | SNV | Missense_Mutation | novel | c.444G>T | p.Glu148Asp | p.E148D | Q9NW97 | protein_coding | tolerated(0.63) | benign(0) | TCGA-AC-A3W7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
TMEM51 | insertion | Frame_Shift_Ins | novel | c.669_670insAAGCTTAAAGGCAAAGGAGGTTTAACACCCAGAT | p.Asn224LysfsTer12 | p.N224Kfs*12 | Q9NW97 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TMEM51 | SNV | Missense_Mutation | novel | c.264G>C | p.Lys88Asn | p.K88N | Q9NW97 | protein_coding | deleterious(0) | possibly_damaging(0.564) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM51 | SNV | Missense_Mutation | c.550N>A | p.Gly184Arg | p.G184R | Q9NW97 | protein_coding | tolerated(0.27) | benign(0.066) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
TMEM51 | SNV | Missense_Mutation | c.325N>G | p.His109Asp | p.H109D | Q9NW97 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TMEM51 | SNV | Missense_Mutation | rs201213892 | c.121G>A | p.Glu41Lys | p.E41K | Q9NW97 | protein_coding | tolerated(0.45) | benign(0.084) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
TMEM51 | SNV | Missense_Mutation | novel | c.299N>C | p.Val100Ala | p.V100A | Q9NW97 | protein_coding | tolerated(0.36) | benign(0.053) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM51 | SNV | Missense_Mutation | rs775821858 | c.283N>A | p.Glu95Lys | p.E95K | Q9NW97 | protein_coding | deleterious(0.05) | benign(0.246) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM51 | SNV | Missense_Mutation | c.458N>C | p.Arg153Thr | p.R153T | Q9NW97 | protein_coding | deleterious(0.01) | possibly_damaging(0.572) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |