Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TMEM41B

Gene summary for TMEM41B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TMEM41B

Gene ID

440026

Gene nametransmembrane protein 41B
Gene AliasTMEM41B
Cytomap11p15.4
Gene Typeprotein-coding
GO ID

GO:0000045

UniProtAcc

Q5BJD5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
440026TMEM41BLZE3DHumanEsophagusHGIN2.94e-054.78e-010.0668
440026TMEM41BLZE4THumanEsophagusESCC8.94e-102.74e-010.0811
440026TMEM41BLZE7THumanEsophagusESCC4.82e-063.64e-010.0667
440026TMEM41BLZE8THumanEsophagusESCC3.77e-034.43e-020.067
440026TMEM41BLZE20THumanEsophagusESCC3.31e-02-6.89e-020.0662
440026TMEM41BLZE24THumanEsophagusESCC2.19e-175.23e-010.0596
440026TMEM41BP1T-EHumanEsophagusESCC1.07e-031.48e-010.0875
440026TMEM41BP2T-EHumanEsophagusESCC3.34e-252.58e-010.1177
440026TMEM41BP4T-EHumanEsophagusESCC2.92e-195.15e-010.1323
440026TMEM41BP5T-EHumanEsophagusESCC6.35e-191.71e-010.1327
440026TMEM41BP8T-EHumanEsophagusESCC3.54e-169.37e-020.0889
440026TMEM41BP9T-EHumanEsophagusESCC8.82e-184.27e-010.1131
440026TMEM41BP10T-EHumanEsophagusESCC4.25e-142.06e-010.116
440026TMEM41BP11T-EHumanEsophagusESCC6.78e-104.63e-010.1426
440026TMEM41BP12T-EHumanEsophagusESCC1.27e-16-2.44e-020.1122
440026TMEM41BP15T-EHumanEsophagusESCC3.15e-111.76e-010.1149
440026TMEM41BP16T-EHumanEsophagusESCC3.33e-15-1.01e-020.1153
440026TMEM41BP17T-EHumanEsophagusESCC7.86e-032.28e-020.1278
440026TMEM41BP19T-EHumanEsophagusESCC6.22e-042.91e-010.1662
440026TMEM41BP20T-EHumanEsophagusESCC9.47e-211.58e-010.1124
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001623617EsophagusESCCmacroautophagy216/8552291/187231.94e-234.57e-21216
GO:000703314EsophagusESCCvacuole organization127/8552180/187231.04e-113.85e-10127
GO:190503712EsophagusESCCautophagosome organization73/8552103/187231.88e-072.93e-0673
GO:000004513EsophagusESCCautophagosome assembly69/855299/187231.10e-061.38e-0569
GO:00162365LiverNAFLDmacroautophagy45/1882291/187232.31e-032.19e-0245
GO:001623621LiverHCCmacroautophagy204/7958291/187238.66e-221.41e-19204
GO:000703311LiverHCCvacuole organization119/7958180/187231.22e-104.25e-09119
GO:19050371LiverHCCautophagosome organization70/7958103/187231.52e-072.82e-0670
GO:00000451LiverHCCautophagosome assembly67/795899/187233.56e-076.07e-0667
GO:00162366LungIACmacroautophagy51/2061291/187235.30e-047.49e-0351
GO:001623612LungAISmacroautophagy46/1849291/187239.21e-041.23e-0246
GO:00070333LungAISvacuole organization29/1849180/187235.70e-034.80e-0229
GO:001623610Oral cavityOSCCmacroautophagy192/7305291/187237.01e-211.14e-18192
GO:00070335Oral cavityOSCCvacuole organization115/7305180/187231.11e-114.00e-10115
GO:19050374Oral cavityOSCCautophagosome organization63/7305103/187234.30e-064.98e-0563
GO:00000454Oral cavityOSCCautophagosome assembly60/730599/187231.09e-051.14e-0460
GO:001623615Oral cavityLPmacroautophagy135/4623291/187234.71e-166.70e-14135
GO:000703313Oral cavityLPvacuole organization79/4623180/187231.26e-084.74e-0779
GO:190503711Oral cavityLPautophagosome organization47/4623103/187232.88e-066.28e-0547
GO:000004512Oral cavityLPautophagosome assembly44/462399/187231.36e-052.40e-0444
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TMEM41BinsertionFrame_Shift_Insnovelc.604_605insGGAATGTTTTGCTCp.Ile202ArgfsTer8p.I202Rfs*8Q5BJD5protein_codingTCGA-A8-A09B-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapy5-fluorouracilSD
TMEM41BSNVMissense_Mutationrs775632699c.14G>Cp.Arg5Thrp.R5TQ5BJD5protein_codingdeleterious_low_confidence(0.05)benign(0)TCGA-C5-A7UH-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
TMEM41BdeletionFrame_Shift_Delc.690delTp.Phe230LeufsTer6p.F230Lfs*6Q5BJD5protein_codingTCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
TMEM41BSNVMissense_Mutationnovelc.703N>Ap.Leu235Ilep.L235IQ5BJD5protein_codingtolerated(0.43)benign(0.03)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
TMEM41BSNVMissense_Mutationc.353N>Ap.Phe118Tyrp.F118YQ5BJD5protein_codingdeleterious(0)possibly_damaging(0.885)TCGA-EI-6881-01Colorectumrectum adenocarcinomaMale<65III/IVChemotherapy5SD
TMEM41BSNVMissense_Mutationnovelc.736A>Cp.Lys246Glnp.K246QQ5BJD5protein_codingtolerated(1)benign(0.012)TCGA-F5-6814-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
TMEM41BSNVMissense_Mutationnovelc.366N>Gp.Ile122Metp.I122MQ5BJD5protein_codingdeleterious(0)possibly_damaging(0.863)TCGA-AP-A1E0-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelSD
TMEM41BSNVMissense_Mutationnovelc.271G>Tp.Asp91Tyrp.D91YQ5BJD5protein_codingdeleterious(0)possibly_damaging(0.897)TCGA-B5-A1MR-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
TMEM41BSNVMissense_Mutationnovelc.109N>Ap.Asp37Asnp.D37NQ5BJD5protein_codingtolerated(0.47)benign(0.023)TCGA-BG-A222-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
TMEM41BSNVMissense_Mutationnovelc.392N>Ap.Gly131Aspp.G131DQ5BJD5protein_codingdeleterious(0)probably_damaging(1)TCGA-DF-A2KU-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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