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Gene: TMEM39B |
Gene summary for TMEM39B |
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Gene information | Species | Human | Gene symbol | TMEM39B | Gene ID | 55116 |
Gene name | transmembrane protein 39B | |
Gene Alias | TMEM39B | |
Cytomap | 1p35.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B3KRL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55116 | TMEM39B | LZE4T | Human | Esophagus | ESCC | 2.38e-07 | 1.25e-01 | 0.0811 |
55116 | TMEM39B | LZE7T | Human | Esophagus | ESCC | 2.15e-07 | 3.03e-01 | 0.0667 |
55116 | TMEM39B | LZE22T | Human | Esophagus | ESCC | 5.54e-03 | 2.88e-01 | 0.068 |
55116 | TMEM39B | LZE24T | Human | Esophagus | ESCC | 6.74e-08 | 1.92e-01 | 0.0596 |
55116 | TMEM39B | LZE6T | Human | Esophagus | ESCC | 1.91e-02 | 1.41e-01 | 0.0845 |
55116 | TMEM39B | P1T-E | Human | Esophagus | ESCC | 3.55e-05 | 2.48e-01 | 0.0875 |
55116 | TMEM39B | P2T-E | Human | Esophagus | ESCC | 1.39e-28 | 6.06e-01 | 0.1177 |
55116 | TMEM39B | P4T-E | Human | Esophagus | ESCC | 1.03e-13 | 3.90e-01 | 0.1323 |
55116 | TMEM39B | P5T-E | Human | Esophagus | ESCC | 9.73e-12 | 2.72e-01 | 0.1327 |
55116 | TMEM39B | P8T-E | Human | Esophagus | ESCC | 4.77e-19 | 2.16e-01 | 0.0889 |
55116 | TMEM39B | P9T-E | Human | Esophagus | ESCC | 1.41e-06 | 1.93e-01 | 0.1131 |
55116 | TMEM39B | P10T-E | Human | Esophagus | ESCC | 6.33e-40 | 7.50e-01 | 0.116 |
55116 | TMEM39B | P11T-E | Human | Esophagus | ESCC | 8.37e-05 | 3.42e-01 | 0.1426 |
55116 | TMEM39B | P12T-E | Human | Esophagus | ESCC | 1.49e-16 | 3.29e-01 | 0.1122 |
55116 | TMEM39B | P15T-E | Human | Esophagus | ESCC | 6.02e-21 | 4.24e-01 | 0.1149 |
55116 | TMEM39B | P16T-E | Human | Esophagus | ESCC | 3.07e-23 | 3.78e-01 | 0.1153 |
55116 | TMEM39B | P17T-E | Human | Esophagus | ESCC | 1.22e-10 | 3.40e-01 | 0.1278 |
55116 | TMEM39B | P20T-E | Human | Esophagus | ESCC | 3.75e-08 | 1.79e-01 | 0.1124 |
55116 | TMEM39B | P21T-E | Human | Esophagus | ESCC | 2.95e-39 | 7.16e-01 | 0.1617 |
55116 | TMEM39B | P22T-E | Human | Esophagus | ESCC | 1.23e-25 | 2.55e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM39B | SNV | Missense_Mutation | rs773789753 | c.1292N>T | p.Ala431Val | p.A431V | Q9GZU3 | protein_coding | tolerated(0.23) | benign(0.053) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM39B | insertion | Frame_Shift_Ins | novel | c.338_339insTA | p.His114ThrfsTer5 | p.H114Tfs*5 | Q9GZU3 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
TMEM39B | deletion | Frame_Shift_Del | novel | c.625delT | p.Cys209AlafsTer32 | p.C209Afs*32 | Q9GZU3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM39B | SNV | Missense_Mutation | rs769428963 | c.1088N>T | p.Ala363Val | p.A363V | Q9GZU3 | protein_coding | deleterious(0.02) | possibly_damaging(0.818) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM39B | SNV | Missense_Mutation | novel | c.1239C>A | p.Phe413Leu | p.F413L | Q9GZU3 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM39B | SNV | Missense_Mutation | rs772011464 | c.491G>A | p.Arg164His | p.R164H | Q9GZU3 | protein_coding | deleterious(0.01) | possibly_damaging(0.628) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM39B | SNV | Missense_Mutation | c.496N>G | p.Thr166Ala | p.T166A | Q9GZU3 | protein_coding | tolerated(0.63) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM39B | SNV | Missense_Mutation | novel | c.1358N>T | p.Ala453Val | p.A453V | Q9GZU3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM39B | SNV | Missense_Mutation | c.952T>C | p.Trp318Arg | p.W318R | Q9GZU3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM39B | SNV | Missense_Mutation | novel | c.514G>T | p.Gly172Cys | p.G172C | Q9GZU3 | protein_coding | deleterious(0.03) | possibly_damaging(0.613) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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