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Gene: TMEM37 |
Gene summary for TMEM37 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM37 | Gene ID | 140738 |
Gene name | transmembrane protein 37 | |
Gene Alias | PR | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8WXS4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140738 | TMEM37 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.53e-03 | 4.22e-01 | -0.1808 |
140738 | TMEM37 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.32e-04 | 2.13e-01 | -0.1001 |
140738 | TMEM37 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.09e-05 | 2.00e-01 | 0.096 |
140738 | TMEM37 | LZE4T | Human | Esophagus | ESCC | 2.87e-17 | 6.87e-01 | 0.0811 |
140738 | TMEM37 | P4T-E | Human | Esophagus | ESCC | 1.81e-18 | 3.48e-01 | 0.1323 |
140738 | TMEM37 | P5T-E | Human | Esophagus | ESCC | 2.34e-05 | 1.85e-01 | 0.1327 |
140738 | TMEM37 | P8T-E | Human | Esophagus | ESCC | 3.42e-06 | 8.64e-02 | 0.0889 |
140738 | TMEM37 | P10T-E | Human | Esophagus | ESCC | 1.12e-51 | 1.49e+00 | 0.116 |
140738 | TMEM37 | P11T-E | Human | Esophagus | ESCC | 3.87e-02 | 1.62e-01 | 0.1426 |
140738 | TMEM37 | P12T-E | Human | Esophagus | ESCC | 1.40e-31 | 6.88e-01 | 0.1122 |
140738 | TMEM37 | P15T-E | Human | Esophagus | ESCC | 5.58e-24 | 6.02e-01 | 0.1149 |
140738 | TMEM37 | P21T-E | Human | Esophagus | ESCC | 4.90e-02 | 3.62e-02 | 0.1617 |
140738 | TMEM37 | P22T-E | Human | Esophagus | ESCC | 2.51e-30 | 7.28e-01 | 0.1236 |
140738 | TMEM37 | P23T-E | Human | Esophagus | ESCC | 7.17e-04 | 2.62e-01 | 0.108 |
140738 | TMEM37 | P26T-E | Human | Esophagus | ESCC | 2.82e-18 | 4.98e-01 | 0.1276 |
140738 | TMEM37 | P27T-E | Human | Esophagus | ESCC | 2.09e-19 | 3.56e-01 | 0.1055 |
140738 | TMEM37 | P28T-E | Human | Esophagus | ESCC | 6.21e-19 | 3.49e-01 | 0.1149 |
140738 | TMEM37 | P30T-E | Human | Esophagus | ESCC | 4.44e-17 | 6.75e-01 | 0.137 |
140738 | TMEM37 | P31T-E | Human | Esophagus | ESCC | 2.97e-11 | 1.51e-01 | 0.1251 |
140738 | TMEM37 | P32T-E | Human | Esophagus | ESCC | 9.86e-07 | 7.21e-02 | 0.1666 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM37 | SNV | Missense_Mutation | c.361N>G | p.Gln121Glu | p.Q121E | Q8WXS4 | protein_coding | tolerated(0.06) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM37 | SNV | Missense_Mutation | novel | c.385A>G | p.Ile129Val | p.I129V | Q8WXS4 | protein_coding | tolerated(1) | benign(0) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM37 | SNV | Missense_Mutation | rs747500777 | c.55N>T | p.Arg19Trp | p.R19W | Q8WXS4 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM37 | SNV | Missense_Mutation | rs780577316 | c.53N>A | p.Arg18His | p.R18H | Q8WXS4 | protein_coding | tolerated(0.74) | benign(0) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
TMEM37 | SNV | Missense_Mutation | rs771071832 | c.304G>A | p.Ala102Thr | p.A102T | Q8WXS4 | protein_coding | deleterious(0.02) | possibly_damaging(0.854) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMEM37 | SNV | Missense_Mutation | novel | c.236N>T | p.Ala79Val | p.A79V | Q8WXS4 | protein_coding | deleterious(0.02) | possibly_damaging(0.461) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM37 | SNV | Missense_Mutation | novel | c.23N>T | p.Ala8Val | p.A8V | Q8WXS4 | protein_coding | tolerated(0.18) | benign(0.069) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TMEM37 | SNV | Missense_Mutation | c.490N>C | p.Cys164Arg | p.C164R | Q8WXS4 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM37 | SNV | Missense_Mutation | rs147714955 | c.167G>A | p.Arg56His | p.R56H | Q8WXS4 | protein_coding | tolerated(0.27) | benign(0) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM37 | SNV | Missense_Mutation | novel | c.376N>G | p.Met126Val | p.M126V | Q8WXS4 | protein_coding | tolerated(0.26) | benign(0) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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