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Gene: TMEM35B |
Gene summary for TMEM35B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM35B | Gene ID | 100506144 |
| Gene name | transmembrane protein 35B | |
| Gene Alias | ZMYM6NB | |
| Cytomap | 1p34.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NCS4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100506144 | TMEM35B | LZE2D | Human | Esophagus | HGIN | 3.64e-03 | 3.79e-01 | 0.0642 |
| 100506144 | TMEM35B | LZE2T | Human | Esophagus | ESCC | 1.52e-08 | 7.78e-01 | 0.082 |
| 100506144 | TMEM35B | LZE3D | Human | Esophagus | HGIN | 8.88e-07 | 7.66e-01 | 0.0668 |
| 100506144 | TMEM35B | LZE4T | Human | Esophagus | ESCC | 7.96e-15 | 3.63e-01 | 0.0811 |
| 100506144 | TMEM35B | LZE5T | Human | Esophagus | ESCC | 1.40e-06 | 3.63e-01 | 0.0514 |
| 100506144 | TMEM35B | LZE7T | Human | Esophagus | ESCC | 1.40e-08 | 4.15e-01 | 0.0667 |
| 100506144 | TMEM35B | LZE8T | Human | Esophagus | ESCC | 2.19e-19 | 5.07e-01 | 0.067 |
| 100506144 | TMEM35B | LZE20T | Human | Esophagus | ESCC | 3.61e-13 | 3.80e-01 | 0.0662 |
| 100506144 | TMEM35B | LZE22D1 | Human | Esophagus | HGIN | 1.90e-05 | 3.26e-01 | 0.0595 |
| 100506144 | TMEM35B | LZE22T | Human | Esophagus | ESCC | 1.00e-09 | 5.62e-01 | 0.068 |
| 100506144 | TMEM35B | LZE24T | Human | Esophagus | ESCC | 3.76e-31 | 7.27e-01 | 0.0596 |
| 100506144 | TMEM35B | LZE6T | Human | Esophagus | ESCC | 9.35e-21 | 6.96e-01 | 0.0845 |
| 100506144 | TMEM35B | HCC2 | Human | Liver | HCC | 7.17e-15 | 2.64e+00 | 0.5341 |
| 100506144 | TMEM35B | S014 | Human | Liver | HCC | 3.33e-15 | 4.24e-01 | 0.2254 |
| 100506144 | TMEM35B | S015 | Human | Liver | HCC | 7.49e-39 | 1.49e+00 | 0.2375 |
| 100506144 | TMEM35B | S016 | Human | Liver | HCC | 9.35e-36 | 9.41e-01 | 0.2243 |
| 100506144 | TMEM35B | S027 | Human | Liver | HCC | 2.78e-14 | 7.10e-01 | 0.2446 |
| 100506144 | TMEM35B | S028 | Human | Liver | HCC | 1.92e-33 | 9.15e-01 | 0.2503 |
| 100506144 | TMEM35B | S029 | Human | Liver | HCC | 2.69e-38 | 1.15e+00 | 0.2581 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM35B | SNV | Missense_Mutation | c.125N>G | p.Gln42Arg | p.Q42R | Q8NCS4 | protein_coding | tolerated(0.29) | benign(0.015) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM35B | SNV | Missense_Mutation | rs768108057 | c.260G>A | p.Ser87Asn | p.S87N | Q8NCS4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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