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Gene: TMEM267 |
Gene summary for TMEM267 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM267 | Gene ID | 64417 |
| Gene name | transmembrane protein 267 | |
| Gene Alias | C5orf28 | |
| Cytomap | 5p12 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R0B8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64417 | TMEM267 | HCC1 | Human | Liver | HCC | 3.68e-12 | 3.33e+00 | 0.5336 |
| 64417 | TMEM267 | HCC2 | Human | Liver | HCC | 2.14e-12 | 1.99e+00 | 0.5341 |
| 64417 | TMEM267 | S014 | Human | Liver | HCC | 4.26e-05 | 2.11e-01 | 0.2254 |
| 64417 | TMEM267 | S015 | Human | Liver | HCC | 2.29e-06 | 3.11e-01 | 0.2375 |
| 64417 | TMEM267 | S016 | Human | Liver | HCC | 9.32e-10 | 2.86e-01 | 0.2243 |
| 64417 | TMEM267 | S028 | Human | Liver | HCC | 2.01e-07 | 3.17e-01 | 0.2503 |
| 64417 | TMEM267 | S029 | Human | Liver | HCC | 2.87e-03 | 2.04e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM267 | SNV | Missense_Mutation | c.458C>A | p.Thr153Asn | p.T153N | Q0VDI3 | protein_coding | tolerated(0.05) | benign(0.295) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| TMEM267 | SNV | Missense_Mutation | rs781542455 | c.484N>T | p.Arg162Cys | p.R162C | Q0VDI3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM267 | SNV | Missense_Mutation | rs187882024 | c.337N>T | p.Pro113Ser | p.P113S | Q0VDI3 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM267 | SNV | Missense_Mutation | rs373129040 | c.560C>T | p.Ser187Phe | p.S187F | Q0VDI3 | protein_coding | tolerated(0.19) | possibly_damaging(0.509) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| TMEM267 | SNV | Missense_Mutation | rs781542455 | c.484C>T | p.Arg162Cys | p.R162C | Q0VDI3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TMEM267 | SNV | Missense_Mutation | c.200N>C | p.Val67Ala | p.V67A | Q0VDI3 | protein_coding | deleterious(0) | benign(0.066) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
| TMEM267 | SNV | Missense_Mutation | c.266T>C | p.Val89Ala | p.V89A | Q0VDI3 | protein_coding | tolerated(0.14) | benign(0.169) | TCGA-AG-4015-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM267 | SNV | Missense_Mutation | c.21G>T | p.Lys7Asn | p.K7N | Q0VDI3 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.856) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TMEM267 | SNV | Missense_Mutation | c.617N>A | p.Ser206Tyr | p.S206Y | Q0VDI3 | protein_coding | deleterious(0) | possibly_damaging(0.605) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| TMEM267 | SNV | Missense_Mutation | rs754947998 | c.634C>T | p.Arg212Cys | p.R212C | Q0VDI3 | protein_coding | tolerated(0.19) | benign(0.235) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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