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Gene: TMEM266 |
Gene summary for TMEM266 |
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Gene information | Species | Human | Gene symbol | TMEM266 | Gene ID | 123591 |
Gene name | transmembrane protein 266 | |
Gene Alias | C15orf27 | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q2M3C6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123591 | TMEM266 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.39e-03 | 1.69e-01 | 0.0155 |
123591 | TMEM266 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.21e-08 | 3.19e-01 | -0.1808 |
123591 | TMEM266 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.30e-07 | 3.63e-01 | -0.0811 |
123591 | TMEM266 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.62e-18 | 4.05e-01 | -0.1954 |
123591 | TMEM266 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.75e-08 | 3.51e-01 | -0.1207 |
123591 | TMEM266 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.41e-10 | 3.32e-01 | -0.1464 |
123591 | TMEM266 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.61e-05 | 2.00e-01 | -0.1001 |
123591 | TMEM266 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.50e-08 | 2.92e-01 | -0.059 |
123591 | TMEM266 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.29e-04 | 3.27e-01 | -0.1706 |
123591 | TMEM266 | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.79e-08 | 4.12e-01 | -0.1462 |
123591 | TMEM266 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.66e-02 | 1.13e-01 | 0.096 |
123591 | TMEM266 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.33e-03 | 2.20e-01 | 0.0338 |
123591 | TMEM266 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.06e-03 | 2.63e-01 | 0.0112 |
123591 | TMEM266 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.65e-20 | 5.44e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM266 | SNV | Missense_Mutation | c.407G>A | p.Gly136Asp | p.G136D | Q2M3C6 | protein_coding | deleterious(0.04) | benign(0.344) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM266 | SNV | Missense_Mutation | novel | c.313N>T | p.Val105Leu | p.V105L | Q2M3C6 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AR-A24P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM266 | SNV | Missense_Mutation | novel | c.1457N>T | p.Asn486Ile | p.N486I | Q2M3C6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.776) | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TMEM266 | insertion | Frame_Shift_Ins | novel | c.199_200insGATTTCAATGGTTGTTGGAAAAGTTT | p.Asn67ArgfsTer23 | p.N67Rfs*23 | Q2M3C6 | protein_coding | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
TMEM266 | deletion | Frame_Shift_Del | c.391delN | p.Ala131HisfsTer7 | p.A131Hfs*7 | Q2M3C6 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
TMEM266 | SNV | Missense_Mutation | rs376932946 | c.1150G>A | p.Ala384Thr | p.A384T | Q2M3C6 | protein_coding | tolerated_low_confidence(0.18) | benign(0.001) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM266 | SNV | Missense_Mutation | novel | c.420N>C | p.Trp140Cys | p.W140C | Q2M3C6 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-HG-A2PA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Taxol | PD |
TMEM266 | SNV | Missense_Mutation | novel | c.1246N>A | p.Glu416Lys | p.E416K | Q2M3C6 | protein_coding | tolerated_low_confidence(0.07) | benign(0.005) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
TMEM266 | SNV | Missense_Mutation | novel | c.376N>G | p.Leu126Val | p.L126V | Q2M3C6 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM266 | SNV | Missense_Mutation | novel | c.778C>T | p.Arg260Trp | p.R260W | Q2M3C6 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-5M-AAT5-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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