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Gene: TMEM251 |
Gene summary for TMEM251 |
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Gene information | Species | Human | Gene symbol | TMEM251 | Gene ID | 26175 |
Gene name | transmembrane protein 251 | |
Gene Alias | C14orf109 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N6I4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26175 | TMEM251 | LZE4T | Human | Esophagus | ESCC | 5.10e-08 | 2.53e-01 | 0.0811 |
26175 | TMEM251 | LZE20T | Human | Esophagus | ESCC | 4.34e-07 | 2.97e-01 | 0.0662 |
26175 | TMEM251 | LZE22T | Human | Esophagus | ESCC | 4.39e-02 | 5.34e-01 | 0.068 |
26175 | TMEM251 | LZE24T | Human | Esophagus | ESCC | 7.84e-11 | 4.28e-01 | 0.0596 |
26175 | TMEM251 | LZE6T | Human | Esophagus | ESCC | 1.88e-02 | 3.37e-01 | 0.0845 |
26175 | TMEM251 | P2T-E | Human | Esophagus | ESCC | 2.34e-12 | 1.63e-01 | 0.1177 |
26175 | TMEM251 | P4T-E | Human | Esophagus | ESCC | 1.49e-11 | 4.45e-01 | 0.1323 |
26175 | TMEM251 | P5T-E | Human | Esophagus | ESCC | 3.36e-08 | 1.30e-01 | 0.1327 |
26175 | TMEM251 | P8T-E | Human | Esophagus | ESCC | 4.90e-22 | 4.82e-01 | 0.0889 |
26175 | TMEM251 | P9T-E | Human | Esophagus | ESCC | 4.72e-09 | 2.04e-01 | 0.1131 |
26175 | TMEM251 | P10T-E | Human | Esophagus | ESCC | 3.16e-33 | 5.94e-01 | 0.116 |
26175 | TMEM251 | P11T-E | Human | Esophagus | ESCC | 6.96e-03 | 4.53e-01 | 0.1426 |
26175 | TMEM251 | P12T-E | Human | Esophagus | ESCC | 4.85e-35 | 6.23e-01 | 0.1122 |
26175 | TMEM251 | P15T-E | Human | Esophagus | ESCC | 6.63e-24 | 5.14e-01 | 0.1149 |
26175 | TMEM251 | P16T-E | Human | Esophagus | ESCC | 3.51e-12 | 2.23e-01 | 0.1153 |
26175 | TMEM251 | P17T-E | Human | Esophagus | ESCC | 7.33e-07 | 2.56e-01 | 0.1278 |
26175 | TMEM251 | P19T-E | Human | Esophagus | ESCC | 7.97e-04 | 5.24e-01 | 0.1662 |
26175 | TMEM251 | P20T-E | Human | Esophagus | ESCC | 4.26e-10 | 2.17e-01 | 0.1124 |
26175 | TMEM251 | P21T-E | Human | Esophagus | ESCC | 9.40e-24 | 3.66e-01 | 0.1617 |
26175 | TMEM251 | P22T-E | Human | Esophagus | ESCC | 1.06e-19 | 3.30e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM251 | insertion | Frame_Shift_Ins | novel | c.393_394insTCAGCCTCCCGAGTAGCTGGGACTACAGGTG | p.Pro132SerfsTer38 | p.P132Sfs*38 | Q8N6I4 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM251 | SNV | Missense_Mutation | novel | c.73N>A | p.Gly25Arg | p.G25R | Q8N6I4 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.714) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
TMEM251 | SNV | Missense_Mutation | novel | c.104N>A | p.Arg35Lys | p.R35K | Q8N6I4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM251 | SNV | Missense_Mutation | novel | c.140N>A | p.Gly47Glu | p.G47E | Q8N6I4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TMEM251 | SNV | Missense_Mutation | c.490C>G | p.Leu164Val | p.L164V | Q8N6I4 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.742) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM251 | SNV | Missense_Mutation | novel | c.334A>G | p.Ile112Val | p.I112V | Q8N6I4 | protein_coding | tolerated_low_confidence(0.32) | benign(0.043) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
TMEM251 | SNV | Missense_Mutation | rs748034329 | c.449N>A | p.Arg150His | p.R150H | Q8N6I4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM251 | SNV | Missense_Mutation | rs748034329 | c.449N>A | p.Arg150His | p.R150H | Q8N6I4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM251 | SNV | Missense_Mutation | rs748034329 | c.449N>A | p.Arg150His | p.R150H | Q8N6I4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM251 | SNV | Missense_Mutation | novel | c.83N>T | p.Arg28Ile | p.R28I | Q8N6I4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.06) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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