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Gene: TMEM245 |
Gene summary for TMEM245 |
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Gene information | Species | Human | Gene symbol | TMEM245 | Gene ID | 23731 |
Gene name | transmembrane protein 245 | |
Gene Alias | C9orf5 | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H330 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23731 | TMEM245 | LZE4T | Human | Esophagus | ESCC | 4.42e-03 | 1.43e-01 | 0.0811 |
23731 | TMEM245 | LZE5T | Human | Esophagus | ESCC | 2.05e-02 | 3.68e-02 | 0.0514 |
23731 | TMEM245 | LZE8T | Human | Esophagus | ESCC | 3.02e-02 | -1.15e-02 | 0.067 |
23731 | TMEM245 | LZE20T | Human | Esophagus | ESCC | 2.41e-04 | 8.42e-02 | 0.0662 |
23731 | TMEM245 | LZE24T | Human | Esophagus | ESCC | 2.28e-15 | 1.99e-01 | 0.0596 |
23731 | TMEM245 | LZE21T | Human | Esophagus | ESCC | 4.49e-05 | 1.21e-01 | 0.0655 |
23731 | TMEM245 | LZE6T | Human | Esophagus | ESCC | 9.80e-04 | 6.39e-02 | 0.0845 |
23731 | TMEM245 | P1T-E | Human | Esophagus | ESCC | 2.16e-08 | 1.40e-01 | 0.0875 |
23731 | TMEM245 | P2T-E | Human | Esophagus | ESCC | 1.70e-27 | 3.07e-01 | 0.1177 |
23731 | TMEM245 | P4T-E | Human | Esophagus | ESCC | 3.40e-20 | 2.19e-01 | 0.1323 |
23731 | TMEM245 | P5T-E | Human | Esophagus | ESCC | 3.22e-18 | 2.31e-01 | 0.1327 |
23731 | TMEM245 | P8T-E | Human | Esophagus | ESCC | 4.98e-11 | 2.52e-01 | 0.0889 |
23731 | TMEM245 | P9T-E | Human | Esophagus | ESCC | 7.46e-12 | 2.74e-01 | 0.1131 |
23731 | TMEM245 | P10T-E | Human | Esophagus | ESCC | 2.67e-20 | 2.68e-01 | 0.116 |
23731 | TMEM245 | P11T-E | Human | Esophagus | ESCC | 1.99e-18 | 5.39e-01 | 0.1426 |
23731 | TMEM245 | P12T-E | Human | Esophagus | ESCC | 5.33e-20 | 1.68e-01 | 0.1122 |
23731 | TMEM245 | P15T-E | Human | Esophagus | ESCC | 3.65e-23 | 4.05e-01 | 0.1149 |
23731 | TMEM245 | P16T-E | Human | Esophagus | ESCC | 2.33e-11 | 9.71e-02 | 0.1153 |
23731 | TMEM245 | P17T-E | Human | Esophagus | ESCC | 1.92e-04 | 1.73e-01 | 0.1278 |
23731 | TMEM245 | P20T-E | Human | Esophagus | ESCC | 1.94e-07 | 1.00e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM245 | SNV | Missense_Mutation | c.1101N>C | p.Gln367His | p.Q367H | Q9H330 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM245 | SNV | Missense_Mutation | c.1957C>T | p.Leu653Phe | p.L653F | Q9H330 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
TMEM245 | SNV | Missense_Mutation | c.1954N>A | p.Leu652Ile | p.L652I | Q9H330 | protein_coding | tolerated(0.4) | possibly_damaging(0.636) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM245 | SNV | Missense_Mutation | novel | c.1751N>C | p.Gly584Ala | p.G584A | Q9H330 | protein_coding | tolerated(0.12) | benign(0.343) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMEM245 | SNV | Missense_Mutation | rs763188586 | c.2087C>G | p.Ser696Cys | p.S696C | Q9H330 | protein_coding | tolerated(0.05) | probably_damaging(0.976) | TCGA-VS-AA62-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TMEM245 | SNV | Missense_Mutation | novel | c.1951N>A | p.Ala651Thr | p.A651T | Q9H330 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM245 | SNV | Missense_Mutation | c.131N>C | p.Leu44Pro | p.L44P | Q9H330 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.998) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM245 | SNV | Missense_Mutation | c.958T>C | p.Ser320Pro | p.S320P | Q9H330 | protein_coding | tolerated(0.34) | benign(0.134) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM245 | SNV | Missense_Mutation | c.916G>A | p.Glu306Lys | p.E306K | Q9H330 | protein_coding | tolerated(0.26) | benign(0.109) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD | |
TMEM245 | deletion | Frame_Shift_Del | novel | c.1166delN | p.Lys389SerfsTer12 | p.K389Sfs*12 | Q9H330 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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