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Gene: TMEM242 |
Gene summary for TMEM242 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM242 | Gene ID | 729515 |
| Gene name | transmembrane protein 242 | |
| Gene Alias | BM033 | |
| Cytomap | 6q25.3 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NWH2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 729515 | TMEM242 | LZE4T | Human | Esophagus | ESCC | 1.77e-12 | 4.43e-01 | 0.0811 |
| 729515 | TMEM242 | LZE7T | Human | Esophagus | ESCC | 1.14e-04 | 3.35e-01 | 0.0667 |
| 729515 | TMEM242 | LZE20T | Human | Esophagus | ESCC | 2.07e-03 | 1.55e-01 | 0.0662 |
| 729515 | TMEM242 | LZE24T | Human | Esophagus | ESCC | 8.68e-09 | 2.15e-01 | 0.0596 |
| 729515 | TMEM242 | LZE21T | Human | Esophagus | ESCC | 5.19e-03 | 3.13e-01 | 0.0655 |
| 729515 | TMEM242 | LZE6T | Human | Esophagus | ESCC | 8.63e-07 | 1.71e-01 | 0.0845 |
| 729515 | TMEM242 | P1T-E | Human | Esophagus | ESCC | 2.83e-05 | 2.35e-01 | 0.0875 |
| 729515 | TMEM242 | P2T-E | Human | Esophagus | ESCC | 4.27e-26 | 3.11e-01 | 0.1177 |
| 729515 | TMEM242 | P4T-E | Human | Esophagus | ESCC | 2.60e-32 | 6.99e-01 | 0.1323 |
| 729515 | TMEM242 | P5T-E | Human | Esophagus | ESCC | 2.40e-24 | 4.57e-01 | 0.1327 |
| 729515 | TMEM242 | P8T-E | Human | Esophagus | ESCC | 2.98e-24 | 2.89e-01 | 0.0889 |
| 729515 | TMEM242 | P9T-E | Human | Esophagus | ESCC | 1.03e-10 | 2.07e-01 | 0.1131 |
| 729515 | TMEM242 | P10T-E | Human | Esophagus | ESCC | 1.43e-29 | 4.07e-01 | 0.116 |
| 729515 | TMEM242 | P11T-E | Human | Esophagus | ESCC | 1.00e-13 | 6.82e-01 | 0.1426 |
| 729515 | TMEM242 | P12T-E | Human | Esophagus | ESCC | 1.51e-19 | 3.72e-01 | 0.1122 |
| 729515 | TMEM242 | P15T-E | Human | Esophagus | ESCC | 3.59e-32 | 6.22e-01 | 0.1149 |
| 729515 | TMEM242 | P16T-E | Human | Esophagus | ESCC | 1.22e-30 | 4.55e-01 | 0.1153 |
| 729515 | TMEM242 | P17T-E | Human | Esophagus | ESCC | 2.90e-19 | 4.14e-01 | 0.1278 |
| 729515 | TMEM242 | P19T-E | Human | Esophagus | ESCC | 6.43e-11 | 7.40e-01 | 0.1662 |
| 729515 | TMEM242 | P20T-E | Human | Esophagus | ESCC | 1.49e-23 | 4.94e-01 | 0.1124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM242 | SNV | Missense_Mutation | c.322C>T | p.His108Tyr | p.H108Y | Q9NWH2 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| TMEM242 | SNV | Missense_Mutation | novel | c.38N>T | p.Ser13Phe | p.S13F | Q9NWH2 | protein_coding | deleterious(0.01) | possibly_damaging(0.58) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TMEM242 | SNV | Missense_Mutation | c.298G>A | p.Ala100Thr | p.A100T | Q9NWH2 | protein_coding | tolerated(0.12) | benign(0.293) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TMEM242 | SNV | Missense_Mutation | novel | c.106N>T | p.Thr36Ser | p.T36S | Q9NWH2 | protein_coding | tolerated(0.44) | benign(0.006) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TMEM242 | SNV | Missense_Mutation | novel | c.262N>A | p.Leu88Met | p.L88M | Q9NWH2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| TMEM242 | SNV | Missense_Mutation | novel | c.361T>G | p.Phe121Val | p.F121V | Q9NWH2 | protein_coding | deleterious(0.01) | possibly_damaging(0.515) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| TMEM242 | SNV | Missense_Mutation | c.145N>C | p.Thr49Pro | p.T49P | Q9NWH2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| TMEM242 | SNV | Missense_Mutation | rs782163487 | c.203C>T | p.Thr68Met | p.T68M | Q9NWH2 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM242 | SNV | Missense_Mutation | novel | c.392N>T | p.Ala131Val | p.A131V | Q9NWH2 | protein_coding | tolerated(0.13) | benign(0.036) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| TMEM242 | SNV | Missense_Mutation | novel | c.165G>T | p.Lys55Asn | p.K55N | Q9NWH2 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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