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Gene: TMEM222 |
Gene summary for TMEM222 |
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Gene information | Species | Human | Gene symbol | TMEM222 | Gene ID | 84065 |
Gene name | transmembrane protein 222 | |
Gene Alias | C1orf160 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H0R3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84065 | TMEM222 | LZE4T | Human | Esophagus | ESCC | 3.08e-05 | 6.60e-02 | 0.0811 |
84065 | TMEM222 | LZE7T | Human | Esophagus | ESCC | 3.59e-03 | 3.13e-01 | 0.0667 |
84065 | TMEM222 | LZE8T | Human | Esophagus | ESCC | 3.73e-08 | 2.41e-01 | 0.067 |
84065 | TMEM222 | LZE20T | Human | Esophagus | ESCC | 7.30e-03 | 1.54e-01 | 0.0662 |
84065 | TMEM222 | LZE22T | Human | Esophagus | ESCC | 4.23e-04 | 4.04e-01 | 0.068 |
84065 | TMEM222 | LZE24T | Human | Esophagus | ESCC | 4.64e-11 | 4.15e-01 | 0.0596 |
84065 | TMEM222 | P1T-E | Human | Esophagus | ESCC | 5.52e-07 | 4.40e-01 | 0.0875 |
84065 | TMEM222 | P2T-E | Human | Esophagus | ESCC | 2.11e-37 | 6.42e-01 | 0.1177 |
84065 | TMEM222 | P4T-E | Human | Esophagus | ESCC | 2.34e-08 | 2.72e-01 | 0.1323 |
84065 | TMEM222 | P5T-E | Human | Esophagus | ESCC | 1.98e-16 | 2.54e-01 | 0.1327 |
84065 | TMEM222 | P8T-E | Human | Esophagus | ESCC | 4.56e-25 | 5.09e-01 | 0.0889 |
84065 | TMEM222 | P9T-E | Human | Esophagus | ESCC | 2.99e-03 | 2.64e-01 | 0.1131 |
84065 | TMEM222 | P10T-E | Human | Esophagus | ESCC | 3.01e-79 | 1.38e+00 | 0.116 |
84065 | TMEM222 | P11T-E | Human | Esophagus | ESCC | 1.28e-13 | 5.55e-01 | 0.1426 |
84065 | TMEM222 | P12T-E | Human | Esophagus | ESCC | 1.07e-14 | 3.36e-01 | 0.1122 |
84065 | TMEM222 | P15T-E | Human | Esophagus | ESCC | 2.89e-22 | 4.22e-01 | 0.1149 |
84065 | TMEM222 | P16T-E | Human | Esophagus | ESCC | 3.64e-19 | 4.06e-01 | 0.1153 |
84065 | TMEM222 | P17T-E | Human | Esophagus | ESCC | 2.49e-09 | 3.97e-01 | 0.1278 |
84065 | TMEM222 | P19T-E | Human | Esophagus | ESCC | 2.84e-04 | 5.37e-01 | 0.1662 |
84065 | TMEM222 | P20T-E | Human | Esophagus | ESCC | 4.29e-38 | 8.01e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM222 | SNV | Missense_Mutation | c.611T>A | p.Val204Asp | p.V204D | Q9H0R3 | protein_coding | deleterious(0) | benign(0.14) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
TMEM222 | SNV | Missense_Mutation | c.479G>A | p.Ser160Asn | p.S160N | Q9H0R3 | protein_coding | deleterious(0.05) | probably_damaging(0.984) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
TMEM222 | SNV | Missense_Mutation | rs551763083 | c.541N>A | p.Val181Ile | p.V181I | Q9H0R3 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TMEM222 | SNV | Missense_Mutation | novel | c.374N>C | p.Val125Ala | p.V125A | Q9H0R3 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM222 | SNV | Missense_Mutation | rs372462929 | c.250N>T | p.Arg84Trp | p.R84W | Q9H0R3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A212-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TMEM222 | SNV | Missense_Mutation | c.92N>T | p.Glu31Val | p.E31V | Q9H0R3 | protein_coding | deleterious(0.05) | benign(0.029) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
TMEM222 | SNV | Missense_Mutation | c.302N>T | p.Lys101Met | p.K101M | Q9H0R3 | protein_coding | deleterious(0.04) | probably_damaging(0.975) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
TMEM222 | SNV | Missense_Mutation | novel | c.224G>A | p.Gly75Asp | p.G75D | Q9H0R3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CQ-A4CB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TMEM222 | SNV | Missense_Mutation | c.208N>G | p.Ile70Val | p.I70V | Q9H0R3 | protein_coding | tolerated(0.13) | benign(0.009) | TCGA-CR-6480-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | |
TMEM222 | SNV | Missense_Mutation | rs753514574 | c.403N>T | p.Arg135Cys | p.R135C | Q9H0R3 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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