Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TMEM208

Gene summary for TMEM208

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TMEM208

Gene ID

29100

Gene nametransmembrane protein 208
Gene AliasHSPC171
Cytomap16q22.1
Gene Typeprotein-coding
GO ID

GO:0006508

UniProtAcc

J3KRY7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
29100TMEM208HTA11_2487_2000001011HumanColorectumSER2.41e-083.48e-01-0.1808
29100TMEM208HTA11_1938_2000001011HumanColorectumAD9.70e-114.03e-01-0.0811
29100TMEM208HTA11_347_2000001011HumanColorectumAD6.37e-072.31e-01-0.1954
29100TMEM208HTA11_2112_2000001011HumanColorectumSER2.18e-034.14e-01-0.2196
29100TMEM208HTA11_3361_2000001011HumanColorectumAD1.26e-031.97e-01-0.1207
29100TMEM208HTA11_83_2000001011HumanColorectumSER7.94e-083.45e-01-0.1526
29100TMEM208HTA11_696_2000001011HumanColorectumAD3.12e-163.86e-01-0.1464
29100TMEM208HTA11_866_2000001011HumanColorectumAD8.73e-062.21e-01-0.1001
29100TMEM208HTA11_1391_2000001011HumanColorectumAD6.08e-165.15e-01-0.059
29100TMEM208HTA11_866_3004761011HumanColorectumAD1.11e-112.38e-010.096
29100TMEM208HTA11_10711_2000001011HumanColorectumAD1.86e-021.16e-010.0338
29100TMEM208HTA11_7696_3000711011HumanColorectumAD8.75e-051.81e-010.0674
29100TMEM208HTA11_6818_2000001011HumanColorectumAD3.30e-023.71e-010.0112
29100TMEM208HTA11_6818_2000001021HumanColorectumAD5.87e-062.27e-010.0588
29100TMEM208HTA11_99999970781_79442HumanColorectumMSS1.21e-061.95e-010.294
29100TMEM208HTA11_99999965104_69814HumanColorectumMSS5.86e-104.81e-010.281
29100TMEM208HTA11_99999971662_82457HumanColorectumMSS1.56e-215.11e-010.3859
29100TMEM208HTA11_99999974143_84620HumanColorectumMSS5.65e-082.43e-010.3005
29100TMEM208LZE4THumanEsophagusESCC5.48e-196.54e-010.0811
29100TMEM208LZE7THumanEsophagusESCC9.15e-157.04e-010.0667
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051604ColorectumADprotein maturation85/3918294/187236.73e-046.91e-0385
GO:0016485ColorectumADprotein processing63/3918225/187236.77e-034.19e-0263
GO:00516041ColorectumSERprotein maturation73/2897294/187231.82e-055.38e-0473
GO:00164851ColorectumSERprotein processing55/2897225/187232.84e-044.67e-0355
GO:00516042ColorectumMSSprotein maturation75/3467294/187231.70e-031.53e-0275
GO:00164852ColorectumMSSprotein processing57/3467225/187236.60e-034.38e-0257
GO:005160417EsophagusHGINprotein maturation68/2587294/187239.77e-062.86e-0468
GO:00164857EsophagusHGINprotein processing49/2587225/187237.04e-049.52e-0349
GO:005160418EsophagusESCCprotein maturation189/8552294/187237.64e-112.39e-09189
GO:001648514EsophagusESCCprotein processing134/8552225/187231.81e-051.60e-04134
GO:00516046LiverCirrhoticprotein maturation121/4634294/187233.54e-101.68e-08121
GO:00164853LiverCirrhoticprotein processing85/4634225/187239.01e-061.32e-0485
GO:005160412LiverHCCprotein maturation171/7958294/187233.80e-088.30e-07171
GO:001648511LiverHCCprotein processing121/7958225/187234.01e-042.71e-03121
GO:005160410Oral cavityOSCCprotein maturation170/7305294/187233.97e-111.28e-09170
GO:00164856Oral cavityOSCCprotein processing121/7305225/187234.56e-065.23e-05121
GO:005160416Oral cavityLPprotein maturation122/4623294/187231.37e-107.72e-09122
GO:001648513Oral cavityLPprotein processing83/4623225/187232.87e-054.52e-0483
GO:00516049ProstateBPHprotein maturation80/3107294/187232.64e-064.23e-0580
GO:00164855ProstateBPHprotein processing62/3107225/187232.22e-052.67e-0462
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TMEM208insertionFrame_Shift_Insnovelc.389_390insCTGCTTGGTGACGAGGAGTGGTACCCGAAAAAGCTCTAGAp.Gly131CysfsTer42p.G131Cfs*42Q9BTX3protein_codingTCGA-BH-A0BR-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
TMEM208SNVMissense_Mutationc.98N>Tp.Ala33Valp.A33VQ9BTX3protein_codingtolerated(0.15)probably_damaging(0.985)TCGA-D5-6928-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
TMEM208SNVMissense_Mutationnovelc.75N>Ap.Phe25Leup.F25LQ9BTX3protein_codingdeleterious(0.04)probably_damaging(0.952)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
TMEM208SNVMissense_Mutationrs749211328c.179N>Ap.Ser60Asnp.S60NQ9BTX3protein_codingdeleterious(0.01)possibly_damaging(0.773)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
TMEM208SNVMissense_Mutationnovelc.37N>Gp.Lys13Glup.K13EQ9BTX3protein_codingdeleterious(0)probably_damaging(0.927)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
TMEM208SNVMissense_Mutationnovelc.317N>Cp.Ile106Thrp.I106TQ9BTX3protein_codingdeleterious(0)possibly_damaging(0.824)TCGA-AX-A1C5-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinSD
TMEM208SNVMissense_Mutationnovelc.328N>Tp.Ala110Serp.A110SQ9BTX3protein_codingtolerated(0.63)probably_damaging(0.986)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
TMEM208SNVMissense_Mutationnovelc.122N>Tp.Thr41Metp.T41MQ9BTX3protein_codingtolerated(0.48)benign(0.093)TCGA-EY-A1GX-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownPD
TMEM208SNVMissense_Mutationrs773193944c.499N>Tp.Arg167Trpp.R167WQ9BTX3protein_codingdeleterious(0)probably_damaging(0.98)TCGA-FI-A2D0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
TMEM208SNVMissense_Mutationrs367799210c.205N>Tp.His69Tyrp.H69YQ9BTX3protein_codingtolerated(0.06)benign(0.014)TCGA-97-7941-01Lunglung adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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