![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM189 |
Gene summary for TMEM189 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM189 | Gene ID | 387521 |
Gene name | plasmanylethanolamine desaturase 1 | |
Gene Alias | CarF | |
Cytomap | 20q13.13 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A5PLL7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
387521 | TMEM189 | LZE4T | Human | Esophagus | ESCC | 2.87e-26 | 9.51e-01 | 0.0811 |
387521 | TMEM189 | LZE7T | Human | Esophagus | ESCC | 8.99e-08 | 3.19e-01 | 0.0667 |
387521 | TMEM189 | LZE8T | Human | Esophagus | ESCC | 5.43e-07 | 2.40e-01 | 0.067 |
387521 | TMEM189 | LZE20T | Human | Esophagus | ESCC | 5.24e-16 | 5.39e-01 | 0.0662 |
387521 | TMEM189 | LZE22D1 | Human | Esophagus | HGIN | 3.83e-05 | 3.15e-01 | 0.0595 |
387521 | TMEM189 | LZE22T | Human | Esophagus | ESCC | 2.45e-02 | 6.51e-01 | 0.068 |
387521 | TMEM189 | LZE24T | Human | Esophagus | ESCC | 3.30e-22 | 7.45e-01 | 0.0596 |
387521 | TMEM189 | LZE21T | Human | Esophagus | ESCC | 6.98e-04 | 7.73e-01 | 0.0655 |
387521 | TMEM189 | P1T-E | Human | Esophagus | ESCC | 3.49e-09 | 7.11e-01 | 0.0875 |
387521 | TMEM189 | P2T-E | Human | Esophagus | ESCC | 1.17e-38 | 8.06e-01 | 0.1177 |
387521 | TMEM189 | P4T-E | Human | Esophagus | ESCC | 1.15e-53 | 1.32e+00 | 0.1323 |
387521 | TMEM189 | P5T-E | Human | Esophagus | ESCC | 7.46e-36 | 6.13e-01 | 0.1327 |
387521 | TMEM189 | P8T-E | Human | Esophagus | ESCC | 6.95e-31 | 6.18e-01 | 0.0889 |
387521 | TMEM189 | P9T-E | Human | Esophagus | ESCC | 3.18e-25 | 6.94e-01 | 0.1131 |
387521 | TMEM189 | P10T-E | Human | Esophagus | ESCC | 4.55e-45 | 7.97e-01 | 0.116 |
387521 | TMEM189 | P11T-E | Human | Esophagus | ESCC | 1.92e-22 | 1.26e+00 | 0.1426 |
387521 | TMEM189 | P12T-E | Human | Esophagus | ESCC | 2.52e-36 | 6.87e-01 | 0.1122 |
387521 | TMEM189 | P15T-E | Human | Esophagus | ESCC | 1.51e-52 | 1.28e+00 | 0.1149 |
387521 | TMEM189 | P16T-E | Human | Esophagus | ESCC | 6.81e-43 | 7.55e-01 | 0.1153 |
387521 | TMEM189 | P17T-E | Human | Esophagus | ESCC | 2.72e-18 | 7.97e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM189 | SNV | Missense_Mutation | rs201575410 | c.761N>T | p.Thr254Met | p.T254M | A5PLL7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM189 | SNV | Missense_Mutation | novel | c.786N>G | p.Asp262Glu | p.D262E | A5PLL7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A01N-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | SD |
TMEM189 | insertion | Frame_Shift_Ins | novel | c.776_777insAATTT | p.Ala260IlefsTer6 | p.A260Ifs*6 | A5PLL7 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |