Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: TMEM186

Gene summary for TMEM186

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

TMEM186

Gene ID

25880

Gene nametransmembrane protein 186
Gene AliasC16orf51
Cytomap16p13.2
Gene Typeprotein-coding
GO ID

GO:0005575

UniProtAcc

Q96B77


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
25880TMEM186LZE4THumanEsophagusESCC6.07e-038.16e-020.0811
25880TMEM186LZE7THumanEsophagusESCC3.11e-021.19e-010.0667
25880TMEM186LZE24THumanEsophagusESCC3.55e-111.32e-010.0596
25880TMEM186P2T-EHumanEsophagusESCC4.52e-153.12e-010.1177
25880TMEM186P4T-EHumanEsophagusESCC9.81e-152.21e-010.1323
25880TMEM186P5T-EHumanEsophagusESCC2.24e-081.49e-010.1327
25880TMEM186P8T-EHumanEsophagusESCC1.10e-041.31e-010.0889
25880TMEM186P9T-EHumanEsophagusESCC1.87e-061.10e-010.1131
25880TMEM186P10T-EHumanEsophagusESCC5.53e-081.07e-010.116
25880TMEM186P11T-EHumanEsophagusESCC3.65e-093.37e-010.1426
25880TMEM186P12T-EHumanEsophagusESCC3.09e-102.28e-010.1122
25880TMEM186P15T-EHumanEsophagusESCC8.14e-091.58e-010.1149
25880TMEM186P16T-EHumanEsophagusESCC1.05e-172.41e-010.1153
25880TMEM186P20T-EHumanEsophagusESCC1.63e-082.40e-010.1124
25880TMEM186P21T-EHumanEsophagusESCC6.00e-233.36e-010.1617
25880TMEM186P22T-EHumanEsophagusESCC1.10e-182.60e-010.1236
25880TMEM186P23T-EHumanEsophagusESCC3.87e-112.78e-010.108
25880TMEM186P24T-EHumanEsophagusESCC1.30e-111.78e-010.1287
25880TMEM186P26T-EHumanEsophagusESCC1.24e-162.24e-010.1276
25880TMEM186P27T-EHumanEsophagusESCC1.17e-121.06e-010.1055
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
TMEM186SNVMissense_Mutationnovelc.344C>Ap.Thr115Asnp.T115NQ96B77protein_codingdeleterious(0.01)benign(0.192)TCGA-A2-A25A-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCytoxanSD
TMEM186insertionIn_Frame_Insnovelc.408_409insACTGAAAATACAAAAATTAGCTGGGCATGGTGGTGGp.Ser136_Gly137insThrGluAsnThrLysIleSerTrpAlaTrpTrpTrpp.S136_G137insTENTKISWAWWWQ96B77protein_codingTCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
TMEM186insertionNonsense_Mutationnovelc.183_184insATACCCATTGAGCAATAATTTCCTTCTTTTTCCAGCCCTTGGCAACp.Phe62IlefsTer6p.F62Ifs*6Q96B77protein_codingTCGA-A8-A0A1-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
TMEM186insertionFrame_Shift_Insnovelc.349_350insAGGAGATCGAGGCCATCCTCGCTAACAGGGTGAAACCGp.Leu117GlnfsTer17p.L117Qfs*17Q96B77protein_codingTCGA-BH-A0HQ-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
TMEM186SNVMissense_Mutationrs140742433c.583N>Tp.Arg195Cysp.R195CQ96B77protein_codingdeleterious(0.02)benign(0.011)TCGA-AA-3494-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyfolinicPR
TMEM186SNVMissense_Mutationnovelc.31T>Gp.Phe11Valp.F11VQ96B77protein_codingtolerated_low_confidence(0.12)benign(0.023)TCGA-AA-3950-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
TMEM186SNVMissense_Mutationrs755239323c.530G>Ap.Arg177Hisp.R177HQ96B77protein_codingdeleterious(0.01)possibly_damaging(0.809)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
TMEM186SNVMissense_Mutationnovelc.162N>Tp.Glu54Aspp.E54DQ96B77protein_codingtolerated(0.11)benign(0.339)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
TMEM186SNVMissense_Mutationrs778794843c.509N>Ap.Arg170Glnp.R170QQ96B77protein_codingtolerated(0.54)benign(0.003)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
TMEM186SNVMissense_Mutationnovelc.104N>Tp.Arg35Metp.R35MQ96B77protein_codingdeleterious(0.03)probably_damaging(0.943)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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