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Gene: TMEM170A |
Gene summary for TMEM170A |
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Gene information | Species | Human | Gene symbol | TMEM170A | Gene ID | 124491 |
Gene name | transmembrane protein 170A | |
Gene Alias | TMEM170 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8WVE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
124491 | TMEM170A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.20e-02 | 9.21e-02 | 0.0155 |
124491 | TMEM170A | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.45e-16 | 4.25e-01 | -0.1808 |
124491 | TMEM170A | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
124491 | TMEM170A | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.04e-15 | 4.41e-01 | -0.0811 |
124491 | TMEM170A | HTA11_78_2000001011 | Human | Colorectum | AD | 4.08e-19 | 5.27e-01 | -0.1088 |
124491 | TMEM170A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.34e-48 | 8.29e-01 | -0.1954 |
124491 | TMEM170A | HTA11_411_2000001011 | Human | Colorectum | SER | 3.33e-15 | 8.01e-01 | -0.2602 |
124491 | TMEM170A | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 4.53e-01 | -0.2196 |
124491 | TMEM170A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.71e-10 | 3.40e-01 | -0.1207 |
124491 | TMEM170A | HTA11_83_2000001011 | Human | Colorectum | SER | 2.70e-12 | 3.47e-01 | -0.1526 |
124491 | TMEM170A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.35e-15 | 3.05e-01 | -0.1464 |
124491 | TMEM170A | HTA11_866_2000001011 | Human | Colorectum | AD | 8.44e-12 | 2.67e-01 | -0.1001 |
124491 | TMEM170A | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.20e-01 | -0.059 |
124491 | TMEM170A | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 1.89e-01 | -0.1706 |
124491 | TMEM170A | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.21e-08 | 3.22e-01 | -0.2061 |
124491 | TMEM170A | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.80e-01 | -0.1462 |
124491 | TMEM170A | HTA11_546_2000001011 | Human | Colorectum | AD | 1.08e-12 | 3.74e-01 | -0.0842 |
124491 | TMEM170A | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.27e-11 | 3.88e-01 | -0.0179 |
124491 | TMEM170A | HTA11_866_3004761011 | Human | Colorectum | AD | 6.35e-11 | 2.66e-01 | 0.096 |
124491 | TMEM170A | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.34e-04 | 3.36e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007029 | Colorectum | AD | endoplasmic reticulum organization | 31/3918 | 87/18723 | 1.08e-03 | 1.00e-02 | 31 |
GO:0071786 | Colorectum | AD | endoplasmic reticulum tubular network organization | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:00070291 | Colorectum | SER | endoplasmic reticulum organization | 23/2897 | 87/18723 | 5.77e-03 | 4.23e-02 | 23 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:000702914 | Esophagus | ESCC | endoplasmic reticulum organization | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:000699811 | Esophagus | ESCC | nuclear envelope organization | 39/8552 | 47/18723 | 1.48e-07 | 2.35e-06 | 39 |
GO:00069994 | Esophagus | ESCC | nuclear pore organization | 14/8552 | 14/18723 | 1.71e-05 | 1.52e-04 | 14 |
GO:00717865 | Esophagus | ESCC | endoplasmic reticulum tubular network organization | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00469316 | Esophagus | ESCC | pore complex assembly | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:00070292 | Liver | Cirrhotic | endoplasmic reticulum organization | 42/4634 | 87/18723 | 1.67e-06 | 3.22e-05 | 42 |
GO:0046931 | Liver | Cirrhotic | pore complex assembly | 12/4634 | 20/18723 | 8.43e-04 | 6.12e-03 | 12 |
GO:00717861 | Liver | Cirrhotic | endoplasmic reticulum tubular network organization | 11/4634 | 18/18723 | 1.13e-03 | 7.73e-03 | 11 |
GO:0006997 | Liver | Cirrhotic | nucleus organization | 48/4634 | 133/18723 | 2.27e-03 | 1.38e-02 | 48 |
GO:000702911 | Liver | HCC | endoplasmic reticulum organization | 64/7958 | 87/18723 | 3.92e-09 | 1.04e-07 | 64 |
GO:00069971 | Liver | HCC | nucleus organization | 82/7958 | 133/18723 | 6.32e-06 | 7.72e-05 | 82 |
GO:0006998 | Liver | HCC | nuclear envelope organization | 34/7958 | 47/18723 | 3.27e-05 | 3.29e-04 | 34 |
GO:00469311 | Liver | HCC | pore complex assembly | 17/7958 | 20/18723 | 1.18e-04 | 9.87e-04 | 17 |
GO:00717862 | Liver | HCC | endoplasmic reticulum tubular network organization | 15/7958 | 18/18723 | 4.74e-04 | 3.12e-03 | 15 |
GO:0006999 | Liver | HCC | nuclear pore organization | 11/7958 | 14/18723 | 6.81e-03 | 2.73e-02 | 11 |
GO:00069974 | Oral cavity | OSCC | nucleus organization | 85/7305 | 133/18723 | 5.12e-09 | 1.12e-07 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM170A | SNV | Missense_Mutation | novel | c.269N>A | p.Gly90Asp | p.G90D | Q8WVE7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TMEM170A | SNV | Missense_Mutation | rs371743640 | c.416N>A | p.Arg139Gln | p.R139Q | Q8WVE7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM170A | SNV | Missense_Mutation | rs376793219 | c.394N>A | p.Val132Ile | p.V132I | Q8WVE7 | protein_coding | tolerated(0.1) | benign(0.147) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM170A | SNV | Missense_Mutation | c.293N>A | p.Gly98Glu | p.G98E | Q8WVE7 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-CC-5263-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TMEM170A | SNV | Missense_Mutation | c.293N>A | p.Gly98Glu | p.G98E | Q8WVE7 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-DD-A1EE-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
TMEM170A | SNV | Missense_Mutation | novel | c.329N>T | p.Arg110Leu | p.R110L | Q8WVE7 | protein_coding | deleterious(0) | benign(0.15) | TCGA-55-6984-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
TMEM170A | SNV | Missense_Mutation | novel | c.243C>G | p.Phe81Leu | p.F81L | Q8WVE7 | protein_coding | tolerated(0.29) | benign(0.331) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMEM170A | SNV | Missense_Mutation | novel | c.334G>T | p.Ala112Ser | p.A112S | Q8WVE7 | protein_coding | tolerated(0.27) | probably_damaging(0.994) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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