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Gene: TMEM168 |
Gene summary for TMEM168 |
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Gene information | Species | Human | Gene symbol | TMEM168 | Gene ID | 64418 |
Gene name | transmembrane protein 168 | |
Gene Alias | TMEM168 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R716 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64418 | TMEM168 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.61e-03 | -3.35e-01 | 0.0155 |
64418 | TMEM168 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.12e-02 | -6.95e-01 | 0.0216 |
64418 | TMEM168 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.24e-03 | 4.82e-01 | -0.1954 |
64418 | TMEM168 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.01e-03 | -3.87e-01 | 0.096 |
64418 | TMEM168 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.16e-03 | -4.08e-01 | 0.0338 |
64418 | TMEM168 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.68e-07 | -3.91e-01 | 0.3005 |
64418 | TMEM168 | F007 | Human | Colorectum | FAP | 1.84e-07 | -4.36e-01 | 0.1176 |
64418 | TMEM168 | A001-C-207 | Human | Colorectum | FAP | 9.92e-10 | -4.17e-01 | 0.1278 |
64418 | TMEM168 | A015-C-203 | Human | Colorectum | FAP | 8.62e-31 | -5.90e-01 | -0.1294 |
64418 | TMEM168 | A015-C-204 | Human | Colorectum | FAP | 4.59e-12 | -5.10e-01 | -0.0228 |
64418 | TMEM168 | A014-C-040 | Human | Colorectum | FAP | 7.65e-07 | -5.10e-01 | -0.1184 |
64418 | TMEM168 | A002-C-201 | Human | Colorectum | FAP | 8.76e-22 | -5.54e-01 | 0.0324 |
64418 | TMEM168 | A002-C-203 | Human | Colorectum | FAP | 3.71e-02 | -2.15e-01 | 0.2786 |
64418 | TMEM168 | A001-C-119 | Human | Colorectum | FAP | 2.27e-16 | -6.33e-01 | -0.1557 |
64418 | TMEM168 | A001-C-108 | Human | Colorectum | FAP | 2.08e-28 | -6.07e-01 | -0.0272 |
64418 | TMEM168 | A002-C-205 | Human | Colorectum | FAP | 7.72e-28 | -6.13e-01 | -0.1236 |
64418 | TMEM168 | A014-C-108 | Human | Colorectum | FAP | 4.54e-02 | -3.56e-01 | -0.124 |
64418 | TMEM168 | A001-C-104 | Human | Colorectum | FAP | 2.94e-06 | -3.25e-01 | 0.0184 |
64418 | TMEM168 | A015-C-005 | Human | Colorectum | FAP | 6.74e-10 | -4.30e-01 | -0.0336 |
64418 | TMEM168 | A015-C-006 | Human | Colorectum | FAP | 2.63e-21 | -6.11e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM168 | SNV | Missense_Mutation | novel | c.1715N>A | p.Ile572Lys | p.I572K | Q9H0V1 | protein_coding | tolerated(0.93) | benign(0) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD |
TMEM168 | deletion | Frame_Shift_Del | novel | c.1815delN | p.Trp605Ter | p.W605* | Q9H0V1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TMEM168 | SNV | Missense_Mutation | c.472N>A | p.Glu158Lys | p.E158K | Q9H0V1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1567G>A | p.Asp523Asn | p.D523N | Q9H0V1 | protein_coding | tolerated(0.22) | benign(0.121) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1381G>A | p.Glu461Lys | p.E461K | Q9H0V1 | protein_coding | deleterious(0.01) | possibly_damaging(0.513) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1671N>T | p.Arg557Ser | p.R557S | Q9H0V1 | protein_coding | deleterious(0.01) | benign(0.33) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM168 | SNV | Missense_Mutation | c.1114G>A | p.Ala372Thr | p.A372T | Q9H0V1 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
TMEM168 | SNV | Missense_Mutation | rs745740456 | c.1456N>A | p.Glu486Lys | p.E486K | Q9H0V1 | protein_coding | deleterious(0.01) | benign(0.38) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM168 | SNV | Missense_Mutation | novel | c.706G>A | p.Asp236Asn | p.D236N | Q9H0V1 | protein_coding | tolerated(0.06) | benign(0.012) | TCGA-AA-3867-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TMEM168 | SNV | Missense_Mutation | rs777473488 | c.100C>T | p.Arg34Trp | p.R34W | Q9H0V1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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