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Gene: TMEM161A |
Gene summary for TMEM161A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TMEM161A | Gene ID | 54929 |
| Gene name | transmembrane protein 161A | |
| Gene Alias | AROS-29 | |
| Cytomap | 19p13.11 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NX61 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54929 | TMEM161A | LZE3D | Human | Esophagus | HGIN | 4.93e-02 | 4.25e-01 | 0.0668 |
| 54929 | TMEM161A | LZE4T | Human | Esophagus | ESCC | 7.74e-09 | 2.38e-01 | 0.0811 |
| 54929 | TMEM161A | LZE7T | Human | Esophagus | ESCC | 5.55e-09 | 5.03e-01 | 0.0667 |
| 54929 | TMEM161A | LZE8T | Human | Esophagus | ESCC | 2.25e-03 | 1.40e-01 | 0.067 |
| 54929 | TMEM161A | LZE20T | Human | Esophagus | ESCC | 1.62e-07 | 1.15e-01 | 0.0662 |
| 54929 | TMEM161A | LZE22T | Human | Esophagus | ESCC | 4.04e-03 | 1.62e-01 | 0.068 |
| 54929 | TMEM161A | LZE24T | Human | Esophagus | ESCC | 9.74e-20 | 4.46e-01 | 0.0596 |
| 54929 | TMEM161A | LZE21T | Human | Esophagus | ESCC | 1.91e-02 | 4.29e-01 | 0.0655 |
| 54929 | TMEM161A | P1T-E | Human | Esophagus | ESCC | 4.21e-08 | 4.34e-01 | 0.0875 |
| 54929 | TMEM161A | P2T-E | Human | Esophagus | ESCC | 3.81e-16 | 2.26e-01 | 0.1177 |
| 54929 | TMEM161A | P4T-E | Human | Esophagus | ESCC | 1.76e-20 | 5.39e-01 | 0.1323 |
| 54929 | TMEM161A | P5T-E | Human | Esophagus | ESCC | 7.57e-15 | 2.45e-01 | 0.1327 |
| 54929 | TMEM161A | P8T-E | Human | Esophagus | ESCC | 5.59e-20 | 3.49e-01 | 0.0889 |
| 54929 | TMEM161A | P9T-E | Human | Esophagus | ESCC | 7.38e-16 | 3.64e-01 | 0.1131 |
| 54929 | TMEM161A | P10T-E | Human | Esophagus | ESCC | 3.54e-32 | 5.33e-01 | 0.116 |
| 54929 | TMEM161A | P11T-E | Human | Esophagus | ESCC | 3.93e-17 | 5.13e-01 | 0.1426 |
| 54929 | TMEM161A | P12T-E | Human | Esophagus | ESCC | 5.02e-36 | 6.38e-01 | 0.1122 |
| 54929 | TMEM161A | P15T-E | Human | Esophagus | ESCC | 1.85e-24 | 4.70e-01 | 0.1149 |
| 54929 | TMEM161A | P16T-E | Human | Esophagus | ESCC | 2.67e-21 | 4.16e-01 | 0.1153 |
| 54929 | TMEM161A | P17T-E | Human | Esophagus | ESCC | 1.33e-16 | 4.87e-01 | 0.1278 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0097193111 | Esophagus | ESCC | intrinsic apoptotic signaling pathway | 222/8552 | 288/18723 | 5.87e-28 | 2.02e-25 | 222 |
| GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
| GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
| GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
| GO:2001242111 | Esophagus | ESCC | regulation of intrinsic apoptotic signaling pathway | 128/8552 | 164/18723 | 1.75e-17 | 1.50e-15 | 128 |
| GO:2001234111 | Esophagus | ESCC | negative regulation of apoptotic signaling pathway | 161/8552 | 224/18723 | 1.24e-15 | 8.09e-14 | 161 |
| GO:000941113 | Esophagus | ESCC | response to UV | 115/8552 | 149/18723 | 3.29e-15 | 1.93e-13 | 115 |
| GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
| GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
| GO:2001243111 | Esophagus | ESCC | negative regulation of intrinsic apoptotic signaling pathway | 78/8552 | 98/18723 | 5.50e-12 | 2.10e-10 | 78 |
| GO:005105417 | Esophagus | ESCC | positive regulation of DNA metabolic process | 139/8552 | 201/18723 | 1.20e-11 | 4.33e-10 | 139 |
| GO:0008630110 | Esophagus | ESCC | intrinsic apoptotic signaling pathway in response to DNA damage | 78/8552 | 99/18723 | 1.43e-11 | 5.08e-10 | 78 |
| GO:000931419 | Esophagus | ESCC | response to radiation | 277/8552 | 456/18723 | 4.42e-11 | 1.43e-09 | 277 |
| GO:003464413 | Esophagus | ESCC | cellular response to UV | 70/8552 | 90/18723 | 4.59e-10 | 1.20e-08 | 70 |
| GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
| GO:007121419 | Esophagus | ESCC | cellular response to abiotic stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
| GO:010400419 | Esophagus | ESCC | cellular response to environmental stimulus | 206/8552 | 331/18723 | 7.52e-10 | 1.88e-08 | 206 |
| GO:007147816 | Esophagus | ESCC | cellular response to radiation | 122/8552 | 186/18723 | 3.07e-08 | 5.73e-07 | 122 |
| GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
| GO:20010228 | Esophagus | ESCC | positive regulation of response to DNA damage stimulus | 69/8552 | 105/18723 | 2.66e-05 | 2.22e-04 | 69 |
| Page: 1 2 3 4 5 6 7 8 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TMEM161A | SNV | Missense_Mutation | c.570N>T | p.Glu190Asp | p.E190D | Q9NX61 | protein_coding | tolerated(1) | benign(0.005) | TCGA-A2-A0ET-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
| TMEM161A | SNV | Missense_Mutation | c.1312N>G | p.Leu438Val | p.L438V | Q9NX61 | protein_coding | deleterious(0.04) | possibly_damaging(0.836) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| TMEM161A | SNV | Missense_Mutation | rs530025077 | c.577N>A | p.Glu193Lys | p.E193K | Q9NX61 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM161A | SNV | Missense_Mutation | rs72993472 | c.682C>T | p.Arg228Cys | p.R228C | Q9NX61 | protein_coding | deleterious(0.01) | probably_damaging(0.947) | TCGA-BH-A5IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
| TMEM161A | SNV | Missense_Mutation | c.1030N>T | p.Arg344Trp | p.R344W | Q9NX61 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A6-A567-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
| TMEM161A | SNV | Missense_Mutation | rs549197484 | c.656N>T | p.Ala219Val | p.A219V | Q9NX61 | protein_coding | tolerated(0.13) | benign(0.005) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
| TMEM161A | SNV | Missense_Mutation | c.904C>T | p.Arg302Cys | p.R302C | Q9NX61 | protein_coding | deleterious(0.01) | benign(0.289) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TMEM161A | SNV | Missense_Mutation | rs372352382 | c.1249N>A | p.Ala417Thr | p.A417T | Q9NX61 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TMEM161A | SNV | Missense_Mutation | novel | c.610N>G | p.Thr204Ala | p.T204A | Q9NX61 | protein_coding | tolerated(0.09) | benign(0.081) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TMEM161A | SNV | Missense_Mutation | rs772837226 | c.145C>T | p.Arg49Trp | p.R49W | Q9NX61 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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