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Gene: TMEM160 |
Gene summary for TMEM160 |
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Gene information | Species | Human | Gene symbol | TMEM160 | Gene ID | 54958 |
Gene name | transmembrane protein 160 | |
Gene Alias | TMEM160 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NX00 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54958 | TMEM160 | LZE2T | Human | Esophagus | ESCC | 6.43e-05 | 7.22e-01 | 0.082 |
54958 | TMEM160 | LZE4T | Human | Esophagus | ESCC | 1.50e-15 | 3.20e-01 | 0.0811 |
54958 | TMEM160 | LZE5T | Human | Esophagus | ESCC | 1.30e-11 | 7.03e-01 | 0.0514 |
54958 | TMEM160 | LZE20T | Human | Esophagus | ESCC | 6.47e-18 | 5.31e-01 | 0.0662 |
54958 | TMEM160 | LZE22D1 | Human | Esophagus | HGIN | 2.72e-05 | 2.14e-01 | 0.0595 |
54958 | TMEM160 | LZE22T | Human | Esophagus | ESCC | 7.43e-12 | 6.63e-01 | 0.068 |
54958 | TMEM160 | LZE24T | Human | Esophagus | ESCC | 1.01e-41 | 1.07e+00 | 0.0596 |
54958 | TMEM160 | LZE21T | Human | Esophagus | ESCC | 1.60e-12 | 7.13e-01 | 0.0655 |
54958 | TMEM160 | P1T-E | Human | Esophagus | ESCC | 8.87e-28 | 9.80e-01 | 0.0875 |
54958 | TMEM160 | P2T-E | Human | Esophagus | ESCC | 1.31e-36 | 6.97e-01 | 0.1177 |
54958 | TMEM160 | P4T-E | Human | Esophagus | ESCC | 2.42e-58 | 1.36e+00 | 0.1323 |
54958 | TMEM160 | P5T-E | Human | Esophagus | ESCC | 1.02e-63 | 1.32e+00 | 0.1327 |
54958 | TMEM160 | P8T-E | Human | Esophagus | ESCC | 3.09e-80 | 1.50e+00 | 0.0889 |
54958 | TMEM160 | P9T-E | Human | Esophagus | ESCC | 2.47e-33 | 6.88e-01 | 0.1131 |
54958 | TMEM160 | P10T-E | Human | Esophagus | ESCC | 3.48e-63 | 1.05e+00 | 0.116 |
54958 | TMEM160 | P11T-E | Human | Esophagus | ESCC | 1.83e-29 | 1.03e+00 | 0.1426 |
54958 | TMEM160 | P12T-E | Human | Esophagus | ESCC | 9.63e-54 | 9.09e-01 | 0.1122 |
54958 | TMEM160 | P15T-E | Human | Esophagus | ESCC | 7.84e-34 | 6.73e-01 | 0.1149 |
54958 | TMEM160 | P16T-E | Human | Esophagus | ESCC | 3.14e-24 | 3.47e-01 | 0.1153 |
54958 | TMEM160 | P17T-E | Human | Esophagus | ESCC | 1.88e-34 | 1.35e+00 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM160 | SNV | Missense_Mutation | c.213N>A | p.Phe71Leu | p.F71L | Q9NX00 | protein_coding | deleterious(0.01) | possibly_damaging(0.76) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM160 | SNV | Missense_Mutation | novel | c.256N>A | p.Val86Ile | p.V86I | Q9NX00 | protein_coding | tolerated(0.14) | benign(0.318) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM160 | SNV | Missense_Mutation | c.279C>A | p.Asp93Glu | p.D93E | Q9NX00 | protein_coding | tolerated(0.14) | benign(0.237) | TCGA-43-3920-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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