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Gene: TMEM156 |
Gene summary for TMEM156 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TMEM156 | Gene ID | 80008 |
Gene name | transmembrane protein 156 | |
Gene Alias | TMEM156 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8N614 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80008 | TMEM156 | HCC1_Meng | Human | Liver | HCC | 2.21e-05 | -2.98e-02 | 0.0246 |
80008 | TMEM156 | cirrhotic2 | Human | Liver | Cirrhotic | 1.02e-04 | 1.60e-01 | 0.0201 |
80008 | TMEM156 | HCC2 | Human | Liver | HCC | 5.57e-04 | 1.03e+00 | 0.5341 |
80008 | TMEM156 | HCC5 | Human | Liver | HCC | 1.05e-03 | 1.95e+00 | 0.4932 |
80008 | TMEM156 | S027 | Human | Liver | HCC | 2.68e-08 | 7.56e-01 | 0.2446 |
80008 | TMEM156 | S028 | Human | Liver | HCC | 2.81e-06 | 4.17e-01 | 0.2503 |
80008 | TMEM156 | S029 | Human | Liver | HCC | 2.58e-11 | 6.69e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM156 | SNV | Missense_Mutation | novel | c.215N>C | p.Arg72Thr | p.R72T | Q8N614 | protein_coding | deleterious(0.01) | benign(0.092) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM156 | SNV | Missense_Mutation | novel | c.100N>A | p.Glu34Lys | p.E34K | Q8N614 | protein_coding | tolerated(0.16) | benign(0.136) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM156 | SNV | Missense_Mutation | c.593C>A | p.Ser198Tyr | p.S198Y | Q8N614 | protein_coding | deleterious(0) | benign(0.243) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
TMEM156 | SNV | Missense_Mutation | c.137T>G | p.Phe46Cys | p.F46C | Q8N614 | protein_coding | deleterious(0.03) | possibly_damaging(0.723) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
TMEM156 | SNV | Missense_Mutation | c.766C>T | p.Leu256Phe | p.L256F | Q8N614 | protein_coding | tolerated(0.06) | benign(0.062) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMEM156 | SNV | Missense_Mutation | c.49T>C | p.Phe17Leu | p.F17L | Q8N614 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM156 | SNV | Missense_Mutation | c.871N>T | p.Pro291Ser | p.P291S | Q8N614 | protein_coding | tolerated(0.14) | benign(0.105) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TMEM156 | SNV | Missense_Mutation | novel | c.605N>G | p.Glu202Gly | p.E202G | Q8N614 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AY-4071-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMEM156 | SNV | Missense_Mutation | c.264N>C | p.Gln88His | p.Q88H | Q8N614 | protein_coding | deleterious(0.04) | possibly_damaging(0.487) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM156 | SNV | Missense_Mutation | c.398N>C | p.Asp133Ala | p.D133A | Q8N614 | protein_coding | tolerated(0.05) | benign(0.018) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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